Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients

Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients

The aim of this study was to investigate the relationship between the combined effect of MTHFR C677T (rs1801133) and EPHX2 G860A (rs751141) polymorphism and ischemic stroke in Chinese T2DM patients. This case-control study included a total of 626 Chinese T2DM patients (236 T2DM patients with ischemi...

Full description

Saved in:

Bibliographic Details
Main Authors:	Liang Ma, Yongwei Jiang, Xiaomu Kong, Meihua Yan, Tingting Zhao, Hailing Zhao, Qian Liu, Haojun Zhang, Yongtong Cao, Ping Li
Format:	Article
Language:	English
Published:	Wiley 2017-01-01
Series:	Journal of Diabetes Research
Online Access:	http://dx.doi.org/10.1155/2017/6216205
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Association of EPHX2 R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients
by: Liang Ma, et al.
Published: (2018-01-01)

Plasma homocysteine concentrationand MTHFR C677T polymorphism are related to ischemic stroke
by: ZHANG Yuchao, XIE Mingzhang, ZHAO Mengmeng, ZHOU Xiaochun, YANG Chenyan, LIU Yanxuan
Published: (2025-03-01)

Association of MTHFR C677T, MTHFR A1298C polymorphism in relation to patients with autism in Thi-Qar Governorate
by: Roaa M. Nashee, et al.
Published: (2024-06-01)

Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer
by: Meng Ye, et al.
Published: (2025-01-01)

Factor V Leiden and MTHFR C677 T polymorphisms and inflammation markers in diabetic retinopathy patients
by: Atefeh Rahimi, et al.
Published: (2025-04-01)

Plasma Homocysteine Level And C677T Polymorphism In MTHFR Gene In Patients With Acute Coronary Syndrome
by: Andrey Grek, et al.
Published: (2015-06-01)

Analysis of MTHFR 1298A>C in addition to MTHFR 677C>T polymorphism as a risk factor for neural tube defects in the Turkish population
by: Koray Boduroğlu, et al.
Published: (2005-10-01)

Hyperhomocysteinemia, C-677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene, and chronic arterial hypertension in pregnant women
by: V. S. Chulkov, et al.
Published: (2012-02-01)

Association Study of MTHFR C677T Polymorphism With Homocysteine Level and Coronary Heart Disease in Elderly Patients
by: Li Chen, et al.
Published: (2025-01-01)

Transient ischemic attacks in a child with post-varicella arteriopathy and MTHFR homozigotic mutation C677T Acidentes isquêmicos transitórios em criança com arteriopatia pós-varicela e mutação MTHFR C677T homozigótica
by: Pedro Beleza, et al.
Published: (2008-06-01)

Polymorphism study of MTHFR 677C?T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq
by: Baghdad Science Journal
Published: (2017-09-01)

Polymorphism study of MTHFR 677C→T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq
by: Muthanna A. Thabit, et al.
Published: (2017-10-01)

The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.
by: Zhen Li, et al.
Published: (2021-01-01)

Methylenetetrahydrofolate reductase (MTHFR) C677T mutation in Turkish patients with thrombosis
by: G Balta, et al.
Published: (1999-04-01)

Study of the <i>MTHFR</i> 677C>T Polymorphism in Children and Adolescents with Hashimoto’s Thyroiditis: An Original Case–Control Study
by: Savvas Kolanis, et al.
Published: (2025-05-01)

Association Between DNA Methylation of MTHFR and Diabetic Kidney Disease
by: Guoxiong Deng, et al.
Published: (2025-01-01)

Single nucleotide polymorphism MTHFR677C>T and the severity of metabolic side effects of antipsychotics in patients with schizophrenia: the results of a pilot study
by: M. A. Kosataya, et al.
Published: (2018-11-01)

Glucose Tolerance, MTHFR C677T and NOS3 G894T Polymorphisms, and Global DNA Methylation in Mixed Ancestry African Individuals
by: Tandi E. Matsha, et al.
Published: (2016-01-01)

MTHFR C677T Polymorphism and Red Blood Cell Folate Concentrations Modifying the Risks of Hepatic Steatosis: A Taiwan Case-Control Study
by: Chien Hsien Wu, et al.
Published: (2025-05-01)

Association between C677T and A1298C MTHFR gene polymorphism and nonsyndromic orofacial clefts in the Turkish population: a case-parent study
by: Aida Semiç-Jusufagiç, et al.
Published: (2012-12-01)

FV Leiden, Prothrombin II, and MTHFR C677T Mutations in Children and Young Adults with Thromboembolic Diseases
by: Sura O. AL-Dewachi, et al.
Published: (2024-12-01)

EPHX1 and ERCC2 polymorphisms are associated with cisplatin-induced nephrotoxicity and prognosis in Thai cancer patients
by: Saad Ahmed, et al.
Published: (2025-01-01)

EPHX1 and ERCC2 polymorphisms are associated with cisplatin-induced nephrotoxicity and prognosis in Thai cancer patients.
by: Saad Ahmed, et al.
Published: (2025-01-01)

A Comprehensive Analysis of Epoxide Hydrolase 2 (EPHX2) in Pan‐Cancer
by: Weiquan Hu, et al.
Published: (2025-03-01)

Analisis Sekuensing Nucleotida pada Mutasi Gen MTHFR C677T pada Kondisi Premature Cardio Infarction
by: Muizzuddin Muizzuddin, et al.
Published: (2012-12-01)

Erratum: FV Leiden, Prothrombin II, and MTHFR C677T Mutations in Children and Young Adults with Thromboembolic Diseases
Published: (2025-01-01)

Prevalence of MTHFR C677T polymorphism and its association with serum homocysteine and blood pressure among different ethnic groups: insights from a cohort study of Nepal
by: Rajendra Dev Bhatt, et al.
Published: (2025-03-01)

Analysis of association between FGB, MTHFR, MTR and MTRR genes polymorphisms and ischemic and hemorrhagic stroke
by: V. I. Tsymbaliuk, et al.
Published: (2020-08-01)

Coexistence of Neurofibromatosis Type-1 and MTHFR C677T Gene Mutation in a Young Stroke Patient: A Case Report
by: Halim Yilmaz, et al.
Published: (2013-01-01)

Evaluation of the Role of Two SNPs in MTHFR Gene Polymorphisms (rs1801133) 677 C>T and (rs 1801131) 1298A>C with Homocysteine Level in Iraqi Patients with Chronic Kidney Disease
by: Saife AL-AHMER, et al.
Published: (2024-08-01)

Association between MYH9 and APOL1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes in a Chinese Han Population
by: Hailing Zhao, et al.
Published: (2018-01-01)

Systematic review and meta-analysis of the relationship between EPHX1 polymorphisms and colorectal cancer risk.
by: Fei Liu, et al.
Published: (2012-01-01)

Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese
by: Liang Ma, et al.
Published: (2020-01-01)

Factor V Leiden, FII G20210A, MTHFR C677T mutations as risk factors for venous thrombosis during pregnancy and puerperium
by: Đorđević Valentina, et al.
Published: (2005-01-01)

Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer.
by: Hong Chen, et al.
Published: (2015-01-01)

Association between EPHX1 polymorphism rs1051740 and the risk of ovarian cancer: a meta-analysis
by: Ying Jin
Published: (2019-12-01)

Association between LXR-α and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population
by: Peng Liu, et al.
Published: (2020-01-01)

Transcriptional Profile of Kidney from Type 2 Diabetic db/db Mice
by: Haojun Zhang, et al.
Published: (2017-01-01)

Early-onset ischaemic stroke in a patient with the novel F2 c.1824C>T gene variant and PAI-1 4G/4G, MTHFR 677TT genotype
by: Pruner Iva, et al.
Published: (2022-01-01)

Interaction of MTHFR polymorphism with PAX1 methylation in cervical cancer
by: Zhou Xiao-Yan, et al.
Published: (2025-04-01)