Polymorphisms and haplotypes in the promoter of the TNF-α gene are associated with disease severity of severe fever with thrombocytopenia syndrome in Chinese Han population.

Polymorphisms and haplotypes in the promoter of the TNF-α gene are associated with disease severity of severe fever with thrombocytopenia syndrome in Chinese Han population.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that is caused by a novel bunyavirus, SFTSV. We assessed whether the single nucleotide polymorphisms (SNPs) in the tumor necrosis factor-alpha (TNF-α) were associated with risk to severity of SFTS. Five TNF-α SNPs (...

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Main Authors: Bo Xing, Xiao-Kun Li, Shao-Fei Zhang, Qing-Bin Lu, Juan Du, Pan-He Zhang, Zhen-Dong Yang, Ning Cui, Chen-Tao Guo, Wu-Chun Cao, Xiao-Ai Zhang, Wei Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006547&type=printable
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