Causal relationship between circulating cytokines and myelodysplastic syndrome: a Mendelian randomization study
Objective: Current research links cytokines to cancer occurrence and development. This study used Mendelian randomization (MR) to examine the causal relationship between circulating cytokines and Myelodysplastic syndrome (MDS) onset. Methods: We analyzed 91 circulating cytokines as exposures and MDS...
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2025.2541447 |
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| author | Xia Wang Ye Zhang Xueqing Xu Xuntao Liu Bin Zhang |
| author_facet | Xia Wang Ye Zhang Xueqing Xu Xuntao Liu Bin Zhang |
| author_sort | Xia Wang |
| collection | DOAJ |
| description | Objective: Current research links cytokines to cancer occurrence and development. This study used Mendelian randomization (MR) to examine the causal relationship between circulating cytokines and Myelodysplastic syndrome (MDS) onset. Methods: We analyzed 91 circulating cytokines as exposures and MDS genome-wide association study (GWAS) summary statistics as outcomes using a two-sample MR approach, with primary results derived from the IVW method. Robustness was assessed through heterogeneity, horizontal pleiotropy, and leave-one-out analyses. Results: In this study, T-cell surface glycoprotein CD6 isoform (OR = 1.247, 95% CI: 1.020-1.524, p = 0.031) and interleukin-24 (OR = 1.679, 95% CI: 1.056-2.669, p = 0.029) were positively associated with MDS risk, while cystatin D (OR = 0.778, 95% CI: 0.642-0.943, p = 0.010) and SIR2-like protein 2 (OR = 0.614, 95% CI: 0.385-0.979, p = 0.041) were negatively associated. These findings were stable in the sensitivity analysis. Conclusions: This MR study provides preliminary evidence that the genetically predicted levels of four circulating cytokines may influence the risk of developing MDS. The specific mechanisms require further exploration. |
| format | Article |
| id | doaj-art-c4bd71a63f944f6e80f2b53184e60835 |
| institution | DOAJ |
| issn | 1607-8454 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj-art-c4bd71a63f944f6e80f2b53184e608352025-08-20T02:47:47ZengTaylor & Francis GroupHematology1607-84542025-12-0130110.1080/16078454.2025.2541447Causal relationship between circulating cytokines and myelodysplastic syndrome: a Mendelian randomization studyXia Wang0Ye Zhang1Xueqing Xu2Xuntao Liu3Bin Zhang4Department of Laboratory Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou, People’s Republic of ChinaGraduate School, Hebei North University, Zhangjiakou, People’s Republic of ChinaGraduate School, Hebei North University, Zhangjiakou, People’s Republic of ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou, People’s Republic of ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou, People’s Republic of ChinaObjective: Current research links cytokines to cancer occurrence and development. This study used Mendelian randomization (MR) to examine the causal relationship between circulating cytokines and Myelodysplastic syndrome (MDS) onset. Methods: We analyzed 91 circulating cytokines as exposures and MDS genome-wide association study (GWAS) summary statistics as outcomes using a two-sample MR approach, with primary results derived from the IVW method. Robustness was assessed through heterogeneity, horizontal pleiotropy, and leave-one-out analyses. Results: In this study, T-cell surface glycoprotein CD6 isoform (OR = 1.247, 95% CI: 1.020-1.524, p = 0.031) and interleukin-24 (OR = 1.679, 95% CI: 1.056-2.669, p = 0.029) were positively associated with MDS risk, while cystatin D (OR = 0.778, 95% CI: 0.642-0.943, p = 0.010) and SIR2-like protein 2 (OR = 0.614, 95% CI: 0.385-0.979, p = 0.041) were negatively associated. These findings were stable in the sensitivity analysis. Conclusions: This MR study provides preliminary evidence that the genetically predicted levels of four circulating cytokines may influence the risk of developing MDS. The specific mechanisms require further exploration.https://www.tandfonline.com/doi/10.1080/16078454.2025.2541447Cytokinesmyelodysplastic syndromeMendelian randomizationGWAS |
| spellingShingle | Xia Wang Ye Zhang Xueqing Xu Xuntao Liu Bin Zhang Causal relationship between circulating cytokines and myelodysplastic syndrome: a Mendelian randomization study Hematology Cytokines myelodysplastic syndrome Mendelian randomization GWAS |
| title | Causal relationship between circulating cytokines and myelodysplastic syndrome: a Mendelian randomization study |
| title_full | Causal relationship between circulating cytokines and myelodysplastic syndrome: a Mendelian randomization study |
| title_fullStr | Causal relationship between circulating cytokines and myelodysplastic syndrome: a Mendelian randomization study |
| title_full_unstemmed | Causal relationship between circulating cytokines and myelodysplastic syndrome: a Mendelian randomization study |
| title_short | Causal relationship between circulating cytokines and myelodysplastic syndrome: a Mendelian randomization study |
| title_sort | causal relationship between circulating cytokines and myelodysplastic syndrome a mendelian randomization study |
| topic | Cytokines myelodysplastic syndrome Mendelian randomization GWAS |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2025.2541447 |
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