Task‐evoked pupillary responses as potential biomarkers of mild cognitive impairment
Abstract INTRODUCTION Eye movement alterations are effective biomarkers for Alzheimer's disease (AD). This study examines task‐evoked pupillary responses (TEPRs) as potential biomarkers of the mild cognitive impairment (MCI), the symptomatic stage preceding AD. METHODS The prospective cohort st...
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| Format: | Article |
| Language: | English |
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Wiley
2024-10-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
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| Online Access: | https://doi.org/10.1002/dad2.70019 |
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| author | Julius Opwonya Kahye Kim Kun Ho Lee Joong Il Kim Jaeuk U. Kim |
| author_facet | Julius Opwonya Kahye Kim Kun Ho Lee Joong Il Kim Jaeuk U. Kim |
| author_sort | Julius Opwonya |
| collection | DOAJ |
| description | Abstract INTRODUCTION Eye movement alterations are effective biomarkers for Alzheimer's disease (AD). This study examines task‐evoked pupillary responses (TEPRs) as potential biomarkers of the mild cognitive impairment (MCI), the symptomatic stage preceding AD. METHODS The prospective cohort study included 213 MCI patients and 514 cognitively normal controls (CNs). Participants performed a prosaccade (PS) or antisaccade (AS) task while their eye movements were tracked using a Tobii Pro Spectrum system. RESULTS The CNs showed unique TEPRs linked to better performance, characterized by larger baselines, greater PS target‐onset variability, and smaller AS target‐onset variability. Conversely, for MCI patients, better performance was linked to larger AS target‐onset sizes. Furthermore, MCI patients displayed reduced dilation during the cue and target‐onset periods compared to CNs. DISCUSSION MCI patients showed altered pupillary response patterns associated with cognitive task performance, highlighting the potential of oculomotor changes as a biomarker for early cognitive decline. Highlights MCI patients displayed markedly smaller pupil dilation than CNs in response to cue and target stimuli. For MCI patients, larger pupil size upon target appearance during antisaccades correlated with better performance. Faster and more consistent prosaccades were linked to better performance in both groups. For MCI patients, the association between longer AS latencies and better performance was more pronounced than in CNs. Combined analysis of TEPRs and saccade performances in a sizeable cohort strengthens the generalizability of our findings to the broader MCI population. |
| format | Article |
| id | doaj-art-c4bc7a454e0348c7978403997bc1888e |
| institution | OA Journals |
| issn | 2352-8729 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
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| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj-art-c4bc7a454e0348c7978403997bc1888e2025-08-20T02:00:55ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292024-10-01164n/an/a10.1002/dad2.70019Task‐evoked pupillary responses as potential biomarkers of mild cognitive impairmentJulius Opwonya0Kahye Kim1Kun Ho Lee2Joong Il Kim3Jaeuk U. Kim4Digital Health Research DivisionKorea Institute of Oriental MedicineDaejeonSouth KoreaDigital Health Research DivisionKorea Institute of Oriental MedicineDaejeonSouth KoreaGwangju Alzheimer's Disease and Related Dementias (GARD) Cohort Research CenterChosun UniversityGwangjuSouth KoreaDigital Health Research DivisionKorea Institute of Oriental MedicineDaejeonSouth KoreaDigital Health Research DivisionKorea Institute of Oriental MedicineDaejeonSouth KoreaAbstract INTRODUCTION Eye movement alterations are effective biomarkers for Alzheimer's disease (AD). This study examines task‐evoked pupillary responses (TEPRs) as potential biomarkers of the mild cognitive impairment (MCI), the symptomatic stage preceding AD. METHODS The prospective cohort study included 213 MCI patients and 514 cognitively normal controls (CNs). Participants performed a prosaccade (PS) or antisaccade (AS) task while their eye movements were tracked using a Tobii Pro Spectrum system. RESULTS The CNs showed unique TEPRs linked to better performance, characterized by larger baselines, greater PS target‐onset variability, and smaller AS target‐onset variability. Conversely, for MCI patients, better performance was linked to larger AS target‐onset sizes. Furthermore, MCI patients displayed reduced dilation during the cue and target‐onset periods compared to CNs. DISCUSSION MCI patients showed altered pupillary response patterns associated with cognitive task performance, highlighting the potential of oculomotor changes as a biomarker for early cognitive decline. Highlights MCI patients displayed markedly smaller pupil dilation than CNs in response to cue and target stimuli. For MCI patients, larger pupil size upon target appearance during antisaccades correlated with better performance. Faster and more consistent prosaccades were linked to better performance in both groups. For MCI patients, the association between longer AS latencies and better performance was more pronounced than in CNs. Combined analysis of TEPRs and saccade performances in a sizeable cohort strengthens the generalizability of our findings to the broader MCI population.https://doi.org/10.1002/dad2.70019locus coeruleusmild cognitive impairmentoculomotorpretectal olivary nucleuspupil sizesaccades |
| spellingShingle | Julius Opwonya Kahye Kim Kun Ho Lee Joong Il Kim Jaeuk U. Kim Task‐evoked pupillary responses as potential biomarkers of mild cognitive impairment Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring locus coeruleus mild cognitive impairment oculomotor pretectal olivary nucleus pupil size saccades |
| title | Task‐evoked pupillary responses as potential biomarkers of mild cognitive impairment |
| title_full | Task‐evoked pupillary responses as potential biomarkers of mild cognitive impairment |
| title_fullStr | Task‐evoked pupillary responses as potential biomarkers of mild cognitive impairment |
| title_full_unstemmed | Task‐evoked pupillary responses as potential biomarkers of mild cognitive impairment |
| title_short | Task‐evoked pupillary responses as potential biomarkers of mild cognitive impairment |
| title_sort | task evoked pupillary responses as potential biomarkers of mild cognitive impairment |
| topic | locus coeruleus mild cognitive impairment oculomotor pretectal olivary nucleus pupil size saccades |
| url | https://doi.org/10.1002/dad2.70019 |
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