Inflammatory Indices and CA 125: A New Approach to Distinguish Ovarian Carcinoma and Borderline Tumors in Suspicious Ovarian Neoplasms from a Retrospective Observational Multicentric Study
<i>Background and Objectives</i>: This study aimed to evaluate the diagnostic potential of systemic inflammatory indices such as Systemic Inflammation Response Index (SIRI) and Systemic Inflammatory Response (SIR). These were assessed in combination with CA 125 to distinguish ovarian car...
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MDPI AG
2025-04-01
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| author | Carlo Ronsini Stefano Restaino Giuseppe Vizzielli Mariano Catello Di Donna Giuseppe Cucinella Maria Cristina Solazzo Cono Scaffa Pasquale De Franciscis Vito Chiantera |
| author_facet | Carlo Ronsini Stefano Restaino Giuseppe Vizzielli Mariano Catello Di Donna Giuseppe Cucinella Maria Cristina Solazzo Cono Scaffa Pasquale De Franciscis Vito Chiantera |
| author_sort | Carlo Ronsini |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: This study aimed to evaluate the diagnostic potential of systemic inflammatory indices such as Systemic Inflammation Response Index (SIRI) and Systemic Inflammatory Response (SIR). These were assessed in combination with CA 125 to distinguish ovarian carcinoma (OC) from borderline ovarian tumors (BOT) in patients with suspicious adnexal masses. <i>Materials and Methods</i>: A retrospective multicenter observational study including patients undergoing surgery for suspected ovarian neoplasms was conducted. Inclusion criteria required preoperative blood sampling for inflammatory markers and CA 125. SIR-125 and SIRI-125 were developed by combining SIR and SIRI with CA 125 levels. Diagnostic performance was assessed using ROC curve analysis and linear regression models. <i>Results</i>: A total of 63 patients (42 BOT, 21 OC) were analyzed. OC patients exhibited significantly higher SIR-125 and SIRI-125 values (<i>p</i> < 0.001). ROC analysis demonstrated good diagnostic accuracy, with AUCs of 0.83 (SIR-125) and 0.82 (SIRI-125). SIR-125 showed higher specificity (0.83), while SIRI-125 had superior sensitivity (0.86). <i>Conclusions</i>: SIR-125 and SIRI-125 enhance diagnostic differentiation between OC and BOT, providing a simple, cost-effective preoperative tool. Future prospective studies are needed to validate these findings in broader patient populations. |
| format | Article |
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| institution | OA Journals |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-c4b923764df243e98e3bcff4f987cc5f2025-08-20T02:33:54ZengMDPI AGMedicina1010-660X1648-91442025-04-0161577710.3390/medicina61050777Inflammatory Indices and CA 125: A New Approach to Distinguish Ovarian Carcinoma and Borderline Tumors in Suspicious Ovarian Neoplasms from a Retrospective Observational Multicentric StudyCarlo Ronsini0Stefano Restaino1Giuseppe Vizzielli2Mariano Catello Di Donna3Giuseppe Cucinella4Maria Cristina Solazzo5Cono Scaffa6Pasquale De Franciscis7Vito Chiantera8Unit of Gynecologic Oncology, National Cancer Institute, IRCCS, Fondazione “G. Pascale”, 80131 Naples, ItalyUnit of Obstetrics and Gynecology, “Santa Maria Della Misericordia” University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, ItalyUnit of Obstetrics and Gynecology, “Santa Maria Della Misericordia” University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, ItalyUnit of Gynecologic Oncology, National Cancer Institute, IRCCS, Fondazione “G. Pascale”, 80131 Naples, ItalyUnit of Gynecologic Oncology, National Cancer Institute, IRCCS, Fondazione “G. Pascale”, 80131 Naples, ItalyUnit of Gynecologic Oncology, National Cancer Institute, IRCCS, Fondazione “G. Pascale”, 80131 Naples, ItalyUnit of Gynecologic Oncology, National Cancer Institute, IRCCS, Fondazione “G. Pascale”, 80131 Naples, ItalyUnit of Gynaecology and Obstetrics, Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyUnit of Gynecologic Oncology, National Cancer Institute, IRCCS, Fondazione “G. Pascale”, 80131 Naples, Italy<i>Background and Objectives</i>: This study aimed to evaluate the diagnostic potential of systemic inflammatory indices such as Systemic Inflammation Response Index (SIRI) and Systemic Inflammatory Response (SIR). These were assessed in combination with CA 125 to distinguish ovarian carcinoma (OC) from borderline ovarian tumors (BOT) in patients with suspicious adnexal masses. <i>Materials and Methods</i>: A retrospective multicenter observational study including patients undergoing surgery for suspected ovarian neoplasms was conducted. Inclusion criteria required preoperative blood sampling for inflammatory markers and CA 125. SIR-125 and SIRI-125 were developed by combining SIR and SIRI with CA 125 levels. Diagnostic performance was assessed using ROC curve analysis and linear regression models. <i>Results</i>: A total of 63 patients (42 BOT, 21 OC) were analyzed. OC patients exhibited significantly higher SIR-125 and SIRI-125 values (<i>p</i> < 0.001). ROC analysis demonstrated good diagnostic accuracy, with AUCs of 0.83 (SIR-125) and 0.82 (SIRI-125). SIR-125 showed higher specificity (0.83), while SIRI-125 had superior sensitivity (0.86). <i>Conclusions</i>: SIR-125 and SIRI-125 enhance diagnostic differentiation between OC and BOT, providing a simple, cost-effective preoperative tool. Future prospective studies are needed to validate these findings in broader patient populations.https://www.mdpi.com/1648-9144/61/5/777ovarian cancerborderline ovarian tumorinflammatory indicesCA 125diagnostic biomarkers |
| spellingShingle | Carlo Ronsini Stefano Restaino Giuseppe Vizzielli Mariano Catello Di Donna Giuseppe Cucinella Maria Cristina Solazzo Cono Scaffa Pasquale De Franciscis Vito Chiantera Inflammatory Indices and CA 125: A New Approach to Distinguish Ovarian Carcinoma and Borderline Tumors in Suspicious Ovarian Neoplasms from a Retrospective Observational Multicentric Study Medicina ovarian cancer borderline ovarian tumor inflammatory indices CA 125 diagnostic biomarkers |
| title | Inflammatory Indices and CA 125: A New Approach to Distinguish Ovarian Carcinoma and Borderline Tumors in Suspicious Ovarian Neoplasms from a Retrospective Observational Multicentric Study |
| title_full | Inflammatory Indices and CA 125: A New Approach to Distinguish Ovarian Carcinoma and Borderline Tumors in Suspicious Ovarian Neoplasms from a Retrospective Observational Multicentric Study |
| title_fullStr | Inflammatory Indices and CA 125: A New Approach to Distinguish Ovarian Carcinoma and Borderline Tumors in Suspicious Ovarian Neoplasms from a Retrospective Observational Multicentric Study |
| title_full_unstemmed | Inflammatory Indices and CA 125: A New Approach to Distinguish Ovarian Carcinoma and Borderline Tumors in Suspicious Ovarian Neoplasms from a Retrospective Observational Multicentric Study |
| title_short | Inflammatory Indices and CA 125: A New Approach to Distinguish Ovarian Carcinoma and Borderline Tumors in Suspicious Ovarian Neoplasms from a Retrospective Observational Multicentric Study |
| title_sort | inflammatory indices and ca 125 a new approach to distinguish ovarian carcinoma and borderline tumors in suspicious ovarian neoplasms from a retrospective observational multicentric study |
| topic | ovarian cancer borderline ovarian tumor inflammatory indices CA 125 diagnostic biomarkers |
| url | https://www.mdpi.com/1648-9144/61/5/777 |
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