ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATION
In recent years the success of transplantation is associated primarily with extensive use of calcineurin inhibitors (CNIs) – cyclosporine and tacrolimus which became the basis of the various immunosuppressive therapy protocols. These drugs despite their effectiveness in the prevention of transplant...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2016-04-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/619 |
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| author | D. V. Doronin A. M. Chernyavskiy A. V. Fomichev M. N. Deryagin V. N. Gorbatykh |
| author_facet | D. V. Doronin A. M. Chernyavskiy A. V. Fomichev M. N. Deryagin V. N. Gorbatykh |
| author_sort | D. V. Doronin |
| collection | DOAJ |
| description | In recent years the success of transplantation is associated primarily with extensive use of calcineurin inhibitors (CNIs) – cyclosporine and tacrolimus which became the basis of the various immunosuppressive therapy protocols. These drugs despite their effectiveness in the prevention of transplant rejection have serious side effects. Nephrosclerosis due to chronic nephrotoxic effect is recognized as the most important of them. But along with chronic nephrotoxic effects there are cases of acute kidney injury on the background of calcineurin inhibitors usage. The article presents a clinical case demonstrating the development of severe reversible nephropathy in a patient after heart transplantation receiving tacrolimus in standard dose. |
| format | Article |
| id | doaj-art-c4aec185bfc74c69947368af1ca9dd88 |
| institution | DOAJ |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2016-04-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-c4aec185bfc74c69947368af1ca9dd882025-08-20T03:21:06ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912016-04-01181535710.15825/1995-1191-2016-1-53-57526ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATIOND. V. Doronin0A. M. Chernyavskiy1A. V. Fomichev2M. N. Deryagin3V. N. Gorbatykh4E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Ministry of Healthcare of the Russian FederationE.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Ministry of Healthcare of the Russian FederationE.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Ministry of Healthcare of the Russian FederationE.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Ministry of Healthcare of the Russian FederationE.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, Ministry of Healthcare of the Russian FederationIn recent years the success of transplantation is associated primarily with extensive use of calcineurin inhibitors (CNIs) – cyclosporine and tacrolimus which became the basis of the various immunosuppressive therapy protocols. These drugs despite their effectiveness in the prevention of transplant rejection have serious side effects. Nephrosclerosis due to chronic nephrotoxic effect is recognized as the most important of them. But along with chronic nephrotoxic effects there are cases of acute kidney injury on the background of calcineurin inhibitors usage. The article presents a clinical case demonstrating the development of severe reversible nephropathy in a patient after heart transplantation receiving tacrolimus in standard dose.https://journal.transpl.ru/vtio/article/view/619heart transplantationinhibitors of calcineurinnephrotoxicity |
| spellingShingle | D. V. Doronin A. M. Chernyavskiy A. V. Fomichev M. N. Deryagin V. N. Gorbatykh ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATION Вестник трансплантологии и искусственных органов heart transplantation inhibitors of calcineurin nephrotoxicity |
| title | ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATION |
| title_full | ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATION |
| title_fullStr | ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATION |
| title_full_unstemmed | ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATION |
| title_short | ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATION |
| title_sort | acute tacrolimus induced kidney insufficiency in patient after heart transplantation |
| topic | heart transplantation inhibitors of calcineurin nephrotoxicity |
| url | https://journal.transpl.ru/vtio/article/view/619 |
| work_keys_str_mv | AT dvdoronin acutetacrolimusinducedkidneyinsufficiencyinpatientafterhearttransplantation AT amchernyavskiy acutetacrolimusinducedkidneyinsufficiencyinpatientafterhearttransplantation AT avfomichev acutetacrolimusinducedkidneyinsufficiencyinpatientafterhearttransplantation AT mnderyagin acutetacrolimusinducedkidneyinsufficiencyinpatientafterhearttransplantation AT vngorbatykh acutetacrolimusinducedkidneyinsufficiencyinpatientafterhearttransplantation |