Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population‐based study
Abstract The objective of this study was to investigate the clinicopathological characteristics and survival outcomes of Paget disease (PD), Paget disease concomitant infiltrating duct carcinoma (PD‐IDC), and Paget disease concomitant intraductal carcinoma (PD‐DCIS). We identified 501,631 female pat...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-06-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.1475 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849425342564925440 |
|---|---|
| author | Yang Zhao He‐Fen Sun Meng‐Ting Chen Shui‐Ping Gao Liang‐Dong Li Hong‐lin Jiang Wei Jin |
| author_facet | Yang Zhao He‐Fen Sun Meng‐Ting Chen Shui‐Ping Gao Liang‐Dong Li Hong‐lin Jiang Wei Jin |
| author_sort | Yang Zhao |
| collection | DOAJ |
| description | Abstract The objective of this study was to investigate the clinicopathological characteristics and survival outcomes of Paget disease (PD), Paget disease concomitant infiltrating duct carcinoma (PD‐IDC), and Paget disease concomitant intraductal carcinoma (PD‐DCIS). We identified 501,631 female patients from 2000 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database. These identified patients included patients with PD (n = 469), patients with PD‐IDC (n = 1832), and patients with PD‐DCIS (n = 1130) and infiltrating ductal carcinoma (IDC) (n = 498,076). Then, we compared the clinical characteristics of these patients with those who were diagnosed with IDC during the same period. The outcomes of these subtypes of breast carcinoma were different. Based on the overall survival, the patients with PD‐IDC had the worst prognosis (5‐year survival rate = 84.1%). The PD‐DCIS had the best prognosis (5‐year survival rate = 97.5%). Besides, among patients with Paget disease, the one who was married had a better prognosis than who were not. And, according to our research, the marital status was associated with the hormone receptor status in patients with PD‐IDC. Among three subtypes of Paget disease, patients with PD‐IDC had the worst prognosis. Besides, patients who were unmarried had worse outcomes. And the marital status of patients with PD‐IDC is associated with hormone status. The observation underscores the importance of individualized treatment. |
| format | Article |
| id | doaj-art-c4a46b5a363c4e228312dd97d3d5e3fd |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-c4a46b5a363c4e228312dd97d3d5e3fd2025-08-20T03:29:48ZengWileyCancer Medicine2045-76342018-06-01762307231810.1002/cam4.1475Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population‐based studyYang Zhao0He‐Fen Sun1Meng‐Ting Chen2Shui‐Ping Gao3Liang‐Dong Li4Hong‐lin Jiang5Wei Jin6Department of Breast Surgery Key Laboratory of Breast Cancer in Shanghai Collaborative Innovation Center of Cancer Medicine Fudan University Shanghai Cancer Center Shanghai 200030 ChinaDepartment of Breast Surgery Key Laboratory of Breast Cancer in Shanghai Collaborative Innovation Center of Cancer Medicine Fudan University Shanghai Cancer Center Shanghai 200030 ChinaDepartment of Breast Surgery Key Laboratory of Breast Cancer in Shanghai Collaborative Innovation Center of Cancer Medicine Fudan University Shanghai Cancer Center Shanghai 200030 ChinaDepartment of Breast Surgery Key Laboratory of Breast Cancer in Shanghai Collaborative Innovation Center of Cancer Medicine Fudan University Shanghai Cancer Center Shanghai 200030 ChinaDepartment of Breast Surgery Key Laboratory of Breast Cancer in Shanghai Collaborative Innovation Center of Cancer Medicine Fudan University Shanghai Cancer Center Shanghai 200030 ChinaDivision of Molecular Medicine & Genetic Department of Internal Medicine and Life Sciences Institute University of Michigan Ann Arbor Michigan 48109Department of Breast Surgery Key Laboratory of Breast Cancer in Shanghai Collaborative Innovation Center of Cancer Medicine Fudan University Shanghai Cancer Center Shanghai 200030 ChinaAbstract The objective of this study was to investigate the clinicopathological characteristics and survival outcomes of Paget disease (PD), Paget disease concomitant infiltrating duct carcinoma (PD‐IDC), and Paget disease concomitant intraductal carcinoma (PD‐DCIS). We identified 501,631 female patients from 2000 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database. These identified patients included patients with PD (n = 469), patients with PD‐IDC (n = 1832), and patients with PD‐DCIS (n = 1130) and infiltrating ductal carcinoma (IDC) (n = 498,076). Then, we compared the clinical characteristics of these patients with those who were diagnosed with IDC during the same period. The outcomes of these subtypes of breast carcinoma were different. Based on the overall survival, the patients with PD‐IDC had the worst prognosis (5‐year survival rate = 84.1%). The PD‐DCIS had the best prognosis (5‐year survival rate = 97.5%). Besides, among patients with Paget disease, the one who was married had a better prognosis than who were not. And, according to our research, the marital status was associated with the hormone receptor status in patients with PD‐IDC. Among three subtypes of Paget disease, patients with PD‐IDC had the worst prognosis. Besides, patients who were unmarried had worse outcomes. And the marital status of patients with PD‐IDC is associated with hormone status. The observation underscores the importance of individualized treatment.https://doi.org/10.1002/cam4.1475Infiltrating ductal carcinomaPaget diseasesurveillance, epidemiology, and end results |
| spellingShingle | Yang Zhao He‐Fen Sun Meng‐Ting Chen Shui‐Ping Gao Liang‐Dong Li Hong‐lin Jiang Wei Jin Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population‐based study Cancer Medicine Infiltrating ductal carcinoma Paget disease surveillance, epidemiology, and end results |
| title | Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population‐based study |
| title_full | Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population‐based study |
| title_fullStr | Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population‐based study |
| title_full_unstemmed | Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population‐based study |
| title_short | Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population‐based study |
| title_sort | clinicopathological characteristics and survival outcomes in paget disease a seer population based study |
| topic | Infiltrating ductal carcinoma Paget disease surveillance, epidemiology, and end results |
| url | https://doi.org/10.1002/cam4.1475 |
| work_keys_str_mv | AT yangzhao clinicopathologicalcharacteristicsandsurvivaloutcomesinpagetdiseaseaseerpopulationbasedstudy AT hefensun clinicopathologicalcharacteristicsandsurvivaloutcomesinpagetdiseaseaseerpopulationbasedstudy AT mengtingchen clinicopathologicalcharacteristicsandsurvivaloutcomesinpagetdiseaseaseerpopulationbasedstudy AT shuipinggao clinicopathologicalcharacteristicsandsurvivaloutcomesinpagetdiseaseaseerpopulationbasedstudy AT liangdongli clinicopathologicalcharacteristicsandsurvivaloutcomesinpagetdiseaseaseerpopulationbasedstudy AT honglinjiang clinicopathologicalcharacteristicsandsurvivaloutcomesinpagetdiseaseaseerpopulationbasedstudy AT weijin clinicopathologicalcharacteristicsandsurvivaloutcomesinpagetdiseaseaseerpopulationbasedstudy |