Beyond the Comfort Zone: Strenuous Sports as a Preventive Tactic Against Benign Prostatic Hyperplasia
Strenuous sports are associated with an enlarged prostate. However, the genetic causality of this association remains unclear. In this study, Mendelian randomization (MR) was used to explore the potential causal relationship between strenuous sports and prostatic hypertrophy. The study utilizes sing...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-02-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/15579883241311209 |
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| _version_ | 1823859130382680064 |
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| author | Wei Zhang Gang Li Chengya Hao Aijun Cheng |
| author_facet | Wei Zhang Gang Li Chengya Hao Aijun Cheng |
| author_sort | Wei Zhang |
| collection | DOAJ |
| description | Strenuous sports are associated with an enlarged prostate. However, the genetic causality of this association remains unclear. In this study, Mendelian randomization (MR) was used to explore the potential causal relationship between strenuous sports and prostatic hypertrophy. The study utilizes single nucleotide polymorphisms (SNPs) associated with strenuous sports obtained from published genome-wide association studies (GWAS), alongside summarized genetic data related to benign prostatic hyperplasia (BPH) from published GWAS. The primary analytical method used is the Inverse Variance-Weighted (IVW) approach for two-sample MR analysis. Heterogeneity of the results is assessed using Cochran’s Q -statistic, while horizontal pleiotropy is evaluated using MR-Egger. Sensitivity analyses include “leave-one-out” tests. The findings indicate a protective causal effect of strenuous sports on BPH (OR = 0.927, 95% CI: [0.870, 0.988]; p = .020). Results from the Weighted Median (WM) method (OR = 0.904, 95% CI: [0.837, 0.978]; p = .011) support this discovery. Using Mendelian randomization, the study provides reliable causal evidence linking high-intensity exercise to a reduced risk of BPH, overcoming biases seen in traditional observational studies. The study demonstrates a causal protective effect of strenuous sports on BPH, suggesting exercise as a preventive strategy for prostate health. |
| format | Article |
| id | doaj-art-c4a2a1a138c14e08a11fe6be9d0d55b4 |
| institution | Kabale University |
| issn | 1557-9891 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj-art-c4a2a1a138c14e08a11fe6be9d0d55b42025-02-11T08:03:43ZengSAGE PublishingAmerican Journal of Men's Health1557-98912025-02-011910.1177/15579883241311209Beyond the Comfort Zone: Strenuous Sports as a Preventive Tactic Against Benign Prostatic HyperplasiaWei Zhang0Gang Li1Chengya Hao2Aijun Cheng3College of Basic Medicine, Jining Medical University, Jining, ChinaSports Department, Harbin Institute of Technology, Harbin, ChinaDepartment of Rehabilitation, Jining Branch Xiyuan Hospital of China Academy of Chinese Medical Sciences, Jining, ChinaDepartment of Rehabilitation, Jining Branch Xiyuan Hospital of China Academy of Chinese Medical Sciences, Jining, ChinaStrenuous sports are associated with an enlarged prostate. However, the genetic causality of this association remains unclear. In this study, Mendelian randomization (MR) was used to explore the potential causal relationship between strenuous sports and prostatic hypertrophy. The study utilizes single nucleotide polymorphisms (SNPs) associated with strenuous sports obtained from published genome-wide association studies (GWAS), alongside summarized genetic data related to benign prostatic hyperplasia (BPH) from published GWAS. The primary analytical method used is the Inverse Variance-Weighted (IVW) approach for two-sample MR analysis. Heterogeneity of the results is assessed using Cochran’s Q -statistic, while horizontal pleiotropy is evaluated using MR-Egger. Sensitivity analyses include “leave-one-out” tests. The findings indicate a protective causal effect of strenuous sports on BPH (OR = 0.927, 95% CI: [0.870, 0.988]; p = .020). Results from the Weighted Median (WM) method (OR = 0.904, 95% CI: [0.837, 0.978]; p = .011) support this discovery. Using Mendelian randomization, the study provides reliable causal evidence linking high-intensity exercise to a reduced risk of BPH, overcoming biases seen in traditional observational studies. The study demonstrates a causal protective effect of strenuous sports on BPH, suggesting exercise as a preventive strategy for prostate health.https://doi.org/10.1177/15579883241311209 |
| spellingShingle | Wei Zhang Gang Li Chengya Hao Aijun Cheng Beyond the Comfort Zone: Strenuous Sports as a Preventive Tactic Against Benign Prostatic Hyperplasia American Journal of Men's Health |
| title | Beyond the Comfort Zone: Strenuous Sports as a Preventive Tactic Against Benign Prostatic Hyperplasia |
| title_full | Beyond the Comfort Zone: Strenuous Sports as a Preventive Tactic Against Benign Prostatic Hyperplasia |
| title_fullStr | Beyond the Comfort Zone: Strenuous Sports as a Preventive Tactic Against Benign Prostatic Hyperplasia |
| title_full_unstemmed | Beyond the Comfort Zone: Strenuous Sports as a Preventive Tactic Against Benign Prostatic Hyperplasia |
| title_short | Beyond the Comfort Zone: Strenuous Sports as a Preventive Tactic Against Benign Prostatic Hyperplasia |
| title_sort | beyond the comfort zone strenuous sports as a preventive tactic against benign prostatic hyperplasia |
| url | https://doi.org/10.1177/15579883241311209 |
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