The Role of Biochemical and Hematological Parameters in Urethral Stricture Recurrence: Inflammation Indexes and De Ritis Rate
Objective: This study investigates the role of hematological inflammation markers in predicting urethral stricture recurrence. Specifically, it examines the prognostic significance of the systemic immune-inflammation index (SII) and De Ritis ratio [aspartate aminotransferase (AST)/alanine aminotrans...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2025-08-01
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| Series: | Forbes Tıp Dergisi |
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| Online Access: | https://forbestip.org/articles/the-role-of-biochemical-and-hematological-parameters-in-urethral-stricture-recurrence-inflammation-indexes-and-de-ritis-rate/doi/forbes.galenos.2025.02350 |
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| author | Serkan ÖZCAN Kürşad DÖNMEZ Enis Mert YORULMAZ Osman KÖSE Sacit Nuri GÖRGEL Yiğit AKIN |
| author_facet | Serkan ÖZCAN Kürşad DÖNMEZ Enis Mert YORULMAZ Osman KÖSE Sacit Nuri GÖRGEL Yiğit AKIN |
| author_sort | Serkan ÖZCAN |
| collection | DOAJ |
| description | Objective: This study investigates the role of hematological inflammation markers in predicting urethral stricture recurrence. Specifically, it examines the prognostic significance of the systemic immune-inflammation index (SII) and De Ritis ratio [aspartate aminotransferase (AST)/alanine aminotransferase ALT)] in recurrence risk.
Methods: This retrospective cohort study included 51 patients who underwent direct visual internal urethrotomy between 2019 and 2023. Patients were divided into recurrence and non-recurrence groups. Clinical data, hematological, and biochemical parameters were analyzed, and the prognostic value of SII and De Ritis ratio (AST/ALT) was assessed using statistical methods.
Results: SII was identified as a significant predictor of recurrence risk (area under the curve=0.689, p=0.023). SII values exceeding 591.42 were associated with a fourfold increase in recurrence risk (odds ratio=4.0, 95% confidence interval: 1.36-11.74, p<0.05). In contrast, the De Ritis ratio (AST/ALT) was not correlated with recurrence (p=0.924). Additionally, stricture length >2 cm was significantly associated with higher recurrence risk (p=0.024).
Conclusion: SII appears to be a valuable biomarker for predicting urethral stricture recurrence. Integrating SII into clinical practice could facilitate early identification of high-risk patients and enable the development of personalized treatment strategies. For patients with high SII values, open urethroplasty may be preferable to repeated endoscopic procedures. However, prospective multicenter studies are needed to validate these findings in larger patient populations. Additionally, machine learning-based prediction models may enhance the accuracy of recurrence risk assessment. |
| format | Article |
| id | doaj-art-c4a24ea8ca644709844459f2ae7566ee |
| institution | Kabale University |
| issn | 2757-5241 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Forbes Tıp Dergisi |
| spelling | doaj-art-c4a24ea8ca644709844459f2ae7566ee2025-08-20T04:00:28ZengGalenos YayineviForbes Tıp Dergisi2757-52412025-08-016211311810.4274/forbes.galenos.2025.02350The Role of Biochemical and Hematological Parameters in Urethral Stricture Recurrence: Inflammation Indexes and De Ritis RateSerkan ÖZCAN0https://orcid.org/0000-0002-2459-139XKürşad DÖNMEZ1https://orcid.org/0000-0003-3581-3338Enis Mert YORULMAZ2https://orcid.org/0000-0003-2109-2015Osman KÖSE3https://orcid.org/0000-0003-4912-2597Sacit Nuri GÖRGEL4https://orcid.org/0000-0001-7628-1249Yiğit AKIN5https://orcid.org/0000-0001-7627-3476İzmir Katip Çelebi University Faculty of Medicine, Department of Urology, İzmir, Türkiyeİzmir Katip Çelebi University Atatürk Training and Research Hospital, Department of Urology, İzmir, Türkiyeİzmir Katip Çelebi University Faculty of Medicine, Department of Urology, İzmir, Türkiyeİzmir Katip Çelebi University Faculty of Medicine, Department of Urology, İzmir, Türkiyeİzmir Katip Çelebi University Faculty of Medicine, Department of Urology, İzmir, Türkiyeİzmir Katip Çelebi University Faculty of Medicine, Department of Urology, İzmir, TürkiyeObjective: This study investigates the role of hematological inflammation markers in predicting urethral stricture recurrence. Specifically, it examines the prognostic significance of the systemic immune-inflammation index (SII) and De Ritis ratio [aspartate aminotransferase (AST)/alanine aminotransferase ALT)] in recurrence risk. Methods: This retrospective cohort study included 51 patients who underwent direct visual internal urethrotomy between 2019 and 2023. Patients were divided into recurrence and non-recurrence groups. Clinical data, hematological, and biochemical parameters were analyzed, and the prognostic value of SII and De Ritis ratio (AST/ALT) was assessed using statistical methods. Results: SII was identified as a significant predictor of recurrence risk (area under the curve=0.689, p=0.023). SII values exceeding 591.42 were associated with a fourfold increase in recurrence risk (odds ratio=4.0, 95% confidence interval: 1.36-11.74, p<0.05). In contrast, the De Ritis ratio (AST/ALT) was not correlated with recurrence (p=0.924). Additionally, stricture length >2 cm was significantly associated with higher recurrence risk (p=0.024). Conclusion: SII appears to be a valuable biomarker for predicting urethral stricture recurrence. Integrating SII into clinical practice could facilitate early identification of high-risk patients and enable the development of personalized treatment strategies. For patients with high SII values, open urethroplasty may be preferable to repeated endoscopic procedures. However, prospective multicenter studies are needed to validate these findings in larger patient populations. Additionally, machine learning-based prediction models may enhance the accuracy of recurrence risk assessment.https://forbestip.org/articles/the-role-of-biochemical-and-hematological-parameters-in-urethral-stricture-recurrence-inflammation-indexes-and-de-ritis-rate/doi/forbes.galenos.2025.02350urethral stricturesystemic immuno-inflammation indexde ritis ratio |
| spellingShingle | Serkan ÖZCAN Kürşad DÖNMEZ Enis Mert YORULMAZ Osman KÖSE Sacit Nuri GÖRGEL Yiğit AKIN The Role of Biochemical and Hematological Parameters in Urethral Stricture Recurrence: Inflammation Indexes and De Ritis Rate Forbes Tıp Dergisi urethral stricture systemic immuno-inflammation index de ritis ratio |
| title | The Role of Biochemical and Hematological Parameters in Urethral Stricture Recurrence: Inflammation Indexes and De Ritis Rate |
| title_full | The Role of Biochemical and Hematological Parameters in Urethral Stricture Recurrence: Inflammation Indexes and De Ritis Rate |
| title_fullStr | The Role of Biochemical and Hematological Parameters in Urethral Stricture Recurrence: Inflammation Indexes and De Ritis Rate |
| title_full_unstemmed | The Role of Biochemical and Hematological Parameters in Urethral Stricture Recurrence: Inflammation Indexes and De Ritis Rate |
| title_short | The Role of Biochemical and Hematological Parameters in Urethral Stricture Recurrence: Inflammation Indexes and De Ritis Rate |
| title_sort | role of biochemical and hematological parameters in urethral stricture recurrence inflammation indexes and de ritis rate |
| topic | urethral stricture systemic immuno-inflammation index de ritis ratio |
| url | https://forbestip.org/articles/the-role-of-biochemical-and-hematological-parameters-in-urethral-stricture-recurrence-inflammation-indexes-and-de-ritis-rate/doi/forbes.galenos.2025.02350 |
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