The Role of Biochemical and Hematological Parameters in Urethral Stricture Recurrence: Inflammation Indexes and De Ritis Rate
Objective: This study investigates the role of hematological inflammation markers in predicting urethral stricture recurrence. Specifically, it examines the prognostic significance of the systemic immune-inflammation index (SII) and De Ritis ratio [aspartate aminotransferase (AST)/alanine aminotrans...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2025-08-01
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| Series: | Forbes Tıp Dergisi |
| Subjects: | |
| Online Access: | https://forbestip.org/articles/the-role-of-biochemical-and-hematological-parameters-in-urethral-stricture-recurrence-inflammation-indexes-and-de-ritis-rate/doi/forbes.galenos.2025.02350 |
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| Summary: | Objective: This study investigates the role of hematological inflammation markers in predicting urethral stricture recurrence. Specifically, it examines the prognostic significance of the systemic immune-inflammation index (SII) and De Ritis ratio [aspartate aminotransferase (AST)/alanine aminotransferase ALT)] in recurrence risk.
Methods: This retrospective cohort study included 51 patients who underwent direct visual internal urethrotomy between 2019 and 2023. Patients were divided into recurrence and non-recurrence groups. Clinical data, hematological, and biochemical parameters were analyzed, and the prognostic value of SII and De Ritis ratio (AST/ALT) was assessed using statistical methods.
Results: SII was identified as a significant predictor of recurrence risk (area under the curve=0.689, p=0.023). SII values exceeding 591.42 were associated with a fourfold increase in recurrence risk (odds ratio=4.0, 95% confidence interval: 1.36-11.74, p<0.05). In contrast, the De Ritis ratio (AST/ALT) was not correlated with recurrence (p=0.924). Additionally, stricture length >2 cm was significantly associated with higher recurrence risk (p=0.024).
Conclusion: SII appears to be a valuable biomarker for predicting urethral stricture recurrence. Integrating SII into clinical practice could facilitate early identification of high-risk patients and enable the development of personalized treatment strategies. For patients with high SII values, open urethroplasty may be preferable to repeated endoscopic procedures. However, prospective multicenter studies are needed to validate these findings in larger patient populations. Additionally, machine learning-based prediction models may enhance the accuracy of recurrence risk assessment. |
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| ISSN: | 2757-5241 |