Pituitary enlargement and hypopituitarism in patient with lung cancer treated with immune checkpoint inhibitors: Metastasis or hypophysitis? Role of imaging
Pituitary gland metastasis is an unusual event, and pituitary metastasis from lung adenocarcinoma is extremely rare and associated with poor prognosis. To date, approximately 16 cases have been reported. Symptoms of these lesions can mimic hypophysitis, that is a possible immune-related adverse even...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-04-01
|
| Series: | Radiology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325000238 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850069593399230464 |
|---|---|
| author | Pier Paolo Arcuri, MD Vincenzo Aiello, MD Simonetta Antonelli, MD Simona Roccia, MD Francesco Manti, MD Domenico Laganà, MD |
| author_facet | Pier Paolo Arcuri, MD Vincenzo Aiello, MD Simonetta Antonelli, MD Simona Roccia, MD Francesco Manti, MD Domenico Laganà, MD |
| author_sort | Pier Paolo Arcuri, MD |
| collection | DOAJ |
| description | Pituitary gland metastasis is an unusual event, and pituitary metastasis from lung adenocarcinoma is extremely rare and associated with poor prognosis. To date, approximately 16 cases have been reported. Symptoms of these lesions can mimic hypophysitis, that is a possible immune-related adverse event of ICIs (Immune Checkpoint Inhibitors). Pituitary metastases and hypophisitis are life-threatening diseases and making differential diagnosis is important, because therapy of these conditions is quite different. Differentiating a condition from the other one is difficult, because many imaging features are not specific. In this presented case, cross-sectional imaging, in particular Magnetic Resonance Imaging (MRI), has revealed itself helpful to suggest the diagnosis of pituitary metastasis rather than hypophysitis. |
| format | Article |
| id | doaj-art-c4a0789a4a144c9d8895dbf108ce8a49 |
| institution | DOAJ |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-c4a0789a4a144c9d8895dbf108ce8a492025-08-20T02:47:45ZengElsevierRadiology Case Reports1930-04332025-04-012041942194710.1016/j.radcr.2025.01.022Pituitary enlargement and hypopituitarism in patient with lung cancer treated with immune checkpoint inhibitors: Metastasis or hypophysitis? Role of imagingPier Paolo Arcuri, MD0Vincenzo Aiello, MD1Simonetta Antonelli, MD2Simona Roccia, MD3Francesco Manti, MD4Domenico Laganà, MD5Radiology Unit “De Lellis”, Azienda Ospedaliero-Universitaria “Renato Dulbecco”, 88100, Catanzaro, Italy; Corresponding author.Rheumatology Clinic “Madonna dello Scoglio” Cotronei, 88836 Crotone, ItalyRadiology Unit “De Lellis”, Azienda Ospedaliero-Universitaria “Renato Dulbecco”, 88100, Catanzaro, ItalyTotal Quality Unit, Lamezia Terme Hospital, ASP Catanzaro, 88100, Catanzaro, ItalyRadiology Unit “Mater Domini”, Azienda Ospedaliero-Universitaria “Renato Dulbecco”, 88100 Catanzaro, Italy“Magna Græcia” Università di Catanzaro, 88100, Catanzaro, Italy; Radiology Unit “Mater Domini”, Azienda Ospedaliero-Universitaria “Renato Dulbecco”, 88100 Catanzaro, ItalyPituitary gland metastasis is an unusual event, and pituitary metastasis from lung adenocarcinoma is extremely rare and associated with poor prognosis. To date, approximately 16 cases have been reported. Symptoms of these lesions can mimic hypophysitis, that is a possible immune-related adverse event of ICIs (Immune Checkpoint Inhibitors). Pituitary metastases and hypophisitis are life-threatening diseases and making differential diagnosis is important, because therapy of these conditions is quite different. Differentiating a condition from the other one is difficult, because many imaging features are not specific. In this presented case, cross-sectional imaging, in particular Magnetic Resonance Imaging (MRI), has revealed itself helpful to suggest the diagnosis of pituitary metastasis rather than hypophysitis.http://www.sciencedirect.com/science/article/pii/S1930043325000238Pituitary metastasesHypophysitisPituitary glandMRIDWIMR spectroscopy |
| spellingShingle | Pier Paolo Arcuri, MD Vincenzo Aiello, MD Simonetta Antonelli, MD Simona Roccia, MD Francesco Manti, MD Domenico Laganà, MD Pituitary enlargement and hypopituitarism in patient with lung cancer treated with immune checkpoint inhibitors: Metastasis or hypophysitis? Role of imaging Radiology Case Reports Pituitary metastases Hypophysitis Pituitary gland MRI DWI MR spectroscopy |
| title | Pituitary enlargement and hypopituitarism in patient with lung cancer treated with immune checkpoint inhibitors: Metastasis or hypophysitis? Role of imaging |
| title_full | Pituitary enlargement and hypopituitarism in patient with lung cancer treated with immune checkpoint inhibitors: Metastasis or hypophysitis? Role of imaging |
| title_fullStr | Pituitary enlargement and hypopituitarism in patient with lung cancer treated with immune checkpoint inhibitors: Metastasis or hypophysitis? Role of imaging |
| title_full_unstemmed | Pituitary enlargement and hypopituitarism in patient with lung cancer treated with immune checkpoint inhibitors: Metastasis or hypophysitis? Role of imaging |
| title_short | Pituitary enlargement and hypopituitarism in patient with lung cancer treated with immune checkpoint inhibitors: Metastasis or hypophysitis? Role of imaging |
| title_sort | pituitary enlargement and hypopituitarism in patient with lung cancer treated with immune checkpoint inhibitors metastasis or hypophysitis role of imaging |
| topic | Pituitary metastases Hypophysitis Pituitary gland MRI DWI MR spectroscopy |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325000238 |
| work_keys_str_mv | AT pierpaoloarcurimd pituitaryenlargementandhypopituitarisminpatientwithlungcancertreatedwithimmunecheckpointinhibitorsmetastasisorhypophysitisroleofimaging AT vincenzoaiellomd pituitaryenlargementandhypopituitarisminpatientwithlungcancertreatedwithimmunecheckpointinhibitorsmetastasisorhypophysitisroleofimaging AT simonettaantonellimd pituitaryenlargementandhypopituitarisminpatientwithlungcancertreatedwithimmunecheckpointinhibitorsmetastasisorhypophysitisroleofimaging AT simonarocciamd pituitaryenlargementandhypopituitarisminpatientwithlungcancertreatedwithimmunecheckpointinhibitorsmetastasisorhypophysitisroleofimaging AT francescomantimd pituitaryenlargementandhypopituitarisminpatientwithlungcancertreatedwithimmunecheckpointinhibitorsmetastasisorhypophysitisroleofimaging AT domenicolaganamd pituitaryenlargementandhypopituitarisminpatientwithlungcancertreatedwithimmunecheckpointinhibitorsmetastasisorhypophysitisroleofimaging |