Diminished ovarian reserve is associated to euploidy rate: a single center study
BackgroundReproductive success shows a well-documented decline with advancing maternal age, primarily due to chromosomal abnormalities (aneuploidies) in embryos. While ovarian reserve markers such as Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC) traditionally serve as quantitative pre...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1535776/full |
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| author | Edoardo Carnesi Stefano Castellano Stefano Castellano Elena Albani Andrea Busnelli Andrea Busnelli Antonella Smeraldi Ozgur Bulbul Emanuela Morenghi Valentina Immediata Paolo Emanuele Levi-Setti Paolo Emanuele Levi-Setti |
| author_facet | Edoardo Carnesi Stefano Castellano Stefano Castellano Elena Albani Andrea Busnelli Andrea Busnelli Antonella Smeraldi Ozgur Bulbul Emanuela Morenghi Valentina Immediata Paolo Emanuele Levi-Setti Paolo Emanuele Levi-Setti |
| author_sort | Edoardo Carnesi |
| collection | DOAJ |
| description | BackgroundReproductive success shows a well-documented decline with advancing maternal age, primarily due to chromosomal abnormalities (aneuploidies) in embryos. While ovarian reserve markers such as Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC) traditionally serve as quantitative predictors of fertility, emerging evidence suggests they may also reflect oocyte quality, particularly in patients with Diminished Ovarian Reserve (DOR). The relationship between these biomarkers and embryo chromosomal status remains complex and poorly understood.MethodsWe conducted a retrospective analysis of in vitro fertilization (IVF) cycles performed between 2015 and 2022, involving 773 female patients who underwent IVF and pre-implantation genetic screening for aneuploidy (PGT-A). Our patient cohort was divided into two groups: Group 1, consisting of women who achieved at least one euploid embryo, and Group 2, comprising women who did not.ResultsThe main outcome measures included the rate and number of euploid blastocysts and their correlation with ovarian reserve. Our results showed a statistically significant association between independent variables and embryo ploidy: AMH levels (OR 1.09; 95% CI 1.04-1.14, p<0.001), the age of the woman (OR 0.82; 95% CI 0.79-0.85, p<0.001), the number of oocytes retrieved (OR 1.050; 95% CI 1.01-1.08, p=0.05), and the fertilization rate (OR 6.69; 95% CI 2.67-16.77, p<0.001).ConclusionOur findings suggest that AMH levels are associated with embryo ploidy rate. These insights could enhance counseling practices in assisted reproductive technology (ART), offering patients a more detailed understanding of their infertility prognosis and the factors influencing IVF outcomes. |
| format | Article |
| id | doaj-art-c49a84e203eb4a6087798d9c896182c9 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-c49a84e203eb4a6087798d9c896182c92025-01-17T15:01:09ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.15357761535776Diminished ovarian reserve is associated to euploidy rate: a single center studyEdoardo Carnesi0Stefano Castellano1Stefano Castellano2Elena Albani3Andrea Busnelli4Andrea Busnelli5Antonella Smeraldi6Ozgur Bulbul7Emanuela Morenghi8Valentina Immediata9Paolo Emanuele Levi-Setti10Paolo Emanuele Levi-Setti11Division of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, ItalyDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, ItalyGenomic Medicine Research Center, Department of Medicine and Surgery, University of Insubria, Varese, ItalyDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, ItalyDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, ItalyDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, ItalyDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, ItalyDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, ItalyDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, ItalyDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, ItalyBackgroundReproductive success shows a well-documented decline with advancing maternal age, primarily due to chromosomal abnormalities (aneuploidies) in embryos. While ovarian reserve markers such as Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC) traditionally serve as quantitative predictors of fertility, emerging evidence suggests they may also reflect oocyte quality, particularly in patients with Diminished Ovarian Reserve (DOR). The relationship between these biomarkers and embryo chromosomal status remains complex and poorly understood.MethodsWe conducted a retrospective analysis of in vitro fertilization (IVF) cycles performed between 2015 and 2022, involving 773 female patients who underwent IVF and pre-implantation genetic screening for aneuploidy (PGT-A). Our patient cohort was divided into two groups: Group 1, consisting of women who achieved at least one euploid embryo, and Group 2, comprising women who did not.ResultsThe main outcome measures included the rate and number of euploid blastocysts and their correlation with ovarian reserve. Our results showed a statistically significant association between independent variables and embryo ploidy: AMH levels (OR 1.09; 95% CI 1.04-1.14, p<0.001), the age of the woman (OR 0.82; 95% CI 0.79-0.85, p<0.001), the number of oocytes retrieved (OR 1.050; 95% CI 1.01-1.08, p=0.05), and the fertilization rate (OR 6.69; 95% CI 2.67-16.77, p<0.001).ConclusionOur findings suggest that AMH levels are associated with embryo ploidy rate. These insights could enhance counseling practices in assisted reproductive technology (ART), offering patients a more detailed understanding of their infertility prognosis and the factors influencing IVF outcomes.https://www.frontiersin.org/articles/10.3389/fendo.2024.1535776/fullAMHassisted reproduction (ART)PGT-Adiminished ovarian reserve (DOR)embryo ploidy rate |
| spellingShingle | Edoardo Carnesi Stefano Castellano Stefano Castellano Elena Albani Andrea Busnelli Andrea Busnelli Antonella Smeraldi Ozgur Bulbul Emanuela Morenghi Valentina Immediata Paolo Emanuele Levi-Setti Paolo Emanuele Levi-Setti Diminished ovarian reserve is associated to euploidy rate: a single center study Frontiers in Endocrinology AMH assisted reproduction (ART) PGT-A diminished ovarian reserve (DOR) embryo ploidy rate |
| title | Diminished ovarian reserve is associated to euploidy rate: a single center study |
| title_full | Diminished ovarian reserve is associated to euploidy rate: a single center study |
| title_fullStr | Diminished ovarian reserve is associated to euploidy rate: a single center study |
| title_full_unstemmed | Diminished ovarian reserve is associated to euploidy rate: a single center study |
| title_short | Diminished ovarian reserve is associated to euploidy rate: a single center study |
| title_sort | diminished ovarian reserve is associated to euploidy rate a single center study |
| topic | AMH assisted reproduction (ART) PGT-A diminished ovarian reserve (DOR) embryo ploidy rate |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1535776/full |
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