Age-related meningeal extracellular matrix remodeling compromises CNS lymphatic function

Age-related meningeal extracellular matrix remodeling compromises CNS lymphatic function

Abstract Efficient clearance of central nervous system (CNS) waste proteins and appropriate immune surveillance is essential for brain health. These processes are facilitated by lymphatic networks present in the meninges that drain cerebrospinal fluid (CSF). Age-related impairments to meningeal lymp...

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Bibliographic Details
Main Authors: Kate Hitpass Romero, Taylor J. Stevenson, Leon C. D. Smyth, Ben Watkin, Samuel J.C. McCullough, Luca Vinnell, Amy M. Smith, Patrick Schweder, Jason A. Correia, Jonathan Kipnis, Mike Dragunow, Justin Rustenhoven
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Neuroinflammation
Subjects:
Fibrosis
Lymphatics
Aging
Traumatic brain injury
Extracellular matrix
Meninges
Online Access:https://doi.org/10.1186/s12974-025-03436-0
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