Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, India
Background: The incidence and prevalence of type 2 diabetes mellitus (T2DM) is increasing due to obesity and sedentary lifestyles. Increased oxidative stress leads to oxidative damage of biomolecules and decreased antioxidant capacity. Aim: The study was designed to determine the malondialdehyde (M...
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| Format: | Article |
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Indonesian Society for Biochemistry and Molecular Biology
2022-07-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/84 |
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| author | Mohammad Zaid Kidwai Roshan Alam Haseeb Ahsan Mohammad Mustufa Khan Saba Khan |
| author_facet | Mohammad Zaid Kidwai Roshan Alam Haseeb Ahsan Mohammad Mustufa Khan Saba Khan |
| author_sort | Mohammad Zaid Kidwai |
| collection | DOAJ |
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Background: The incidence and prevalence of type 2 diabetes mellitus (T2DM) is increasing due to obesity and sedentary lifestyles. Increased oxidative stress leads to oxidative damage of biomolecules and decreased antioxidant capacity.
Aim: The study was designed to determine the malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) in T2DM patients at IIMS&R Hospital, Lucknow.
Method: The oxidative stress was analyzed in T2DM patients as MDA. The total antioxidant capacity was estimated through the FRAP in T2DM patients and control subjects.
Results: The level of MDA was observed to be higher (4.84 ± 1.09) in T2DM patients compared to controls (2.20 ± 0.85). The FRAP was lower among T2DM patients (509.46 ± 126.36) compared to controls (895.62 ± 179.92). The difference between FRAP in T2DM patients and controls was statistically significant (p=0.0001).
Conclusion: MDA was found to be higher in T2DM, and the FRAP level was lower in T2DM patients compared to controls, signifying increased oxidative stress and decreased antioxidant level in T2DM patients.
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| format | Article |
| id | doaj-art-c491888e515e424c995eab4b11a0a01a |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-c491888e515e424c995eab4b11a0a01a2025-02-08T03:06:01ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222022-07-015110.32889/actabioina.84Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, IndiaMohammad Zaid Kidwai0Roshan Alam1Haseeb Ahsan2Mohammad Mustufa Khan3Saba Khan4Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, IndiaDepartment of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, IndiaDepartment of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, IndiaDepartment of Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research, Integral University, Lucknow, IndiaDepartment of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India Background: The incidence and prevalence of type 2 diabetes mellitus (T2DM) is increasing due to obesity and sedentary lifestyles. Increased oxidative stress leads to oxidative damage of biomolecules and decreased antioxidant capacity. Aim: The study was designed to determine the malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) in T2DM patients at IIMS&R Hospital, Lucknow. Method: The oxidative stress was analyzed in T2DM patients as MDA. The total antioxidant capacity was estimated through the FRAP in T2DM patients and control subjects. Results: The level of MDA was observed to be higher (4.84 ± 1.09) in T2DM patients compared to controls (2.20 ± 0.85). The FRAP was lower among T2DM patients (509.46 ± 126.36) compared to controls (895.62 ± 179.92). The difference between FRAP in T2DM patients and controls was statistically significant (p=0.0001). Conclusion: MDA was found to be higher in T2DM, and the FRAP level was lower in T2DM patients compared to controls, signifying increased oxidative stress and decreased antioxidant level in T2DM patients. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/84oxidative stressantioxidantferric reducing ability of plasmaFRAPMDAmalondialdehyde |
| spellingShingle | Mohammad Zaid Kidwai Roshan Alam Haseeb Ahsan Mohammad Mustufa Khan Saba Khan Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, India Acta Biochimica Indonesiana oxidative stress antioxidant ferric reducing ability of plasma FRAP MDA malondialdehyde |
| title | Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, India |
| title_full | Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, India |
| title_fullStr | Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, India |
| title_full_unstemmed | Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, India |
| title_short | Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, India |
| title_sort | analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in lucknow city india |
| topic | oxidative stress antioxidant ferric reducing ability of plasma FRAP MDA malondialdehyde |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/84 |
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