Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare case
B-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) is a type of malignancy involving uncontrolled proliferation of B-precursor lymphoid cells. This case report delineates B-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) manifesting in the mandible and medullary regions of a 10-year-old female. Cli...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Oral Oncology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024000396 |
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| author | Paulo Victor Mendes Penafort Lady Paola Aristizabal Arboleda Sérgio Takashi Kussaba Izilda Aparecida Cardinalli Regina Maria Holanda de Mendonça Márcio Ajudarte Lopes Pablo Agustin Vargas Alan Roger Santos-Silva |
| author_facet | Paulo Victor Mendes Penafort Lady Paola Aristizabal Arboleda Sérgio Takashi Kussaba Izilda Aparecida Cardinalli Regina Maria Holanda de Mendonça Márcio Ajudarte Lopes Pablo Agustin Vargas Alan Roger Santos-Silva |
| author_sort | Paulo Victor Mendes Penafort |
| collection | DOAJ |
| description | B-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) is a type of malignancy involving uncontrolled proliferation of B-precursor lymphoid cells. This case report delineates B-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) manifesting in the mandible and medullary regions of a 10-year-old female. Clinically, an irregular swelling with bone cortical destruction and weight loss was observed. Histopathological examination revealed proliferation of CD10, CD43, CD79a, PAX-5, TDT, CD99, and FLI-1 positive small round blue cells, with a 49% lymphoblast infiltration in the bone marrow. Chemotherapy was administered, leading to disease control during the 5-year follow-up. |
| format | Article |
| id | doaj-art-c48fd6677f6e4f90b1dce0b762f5c077 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-c48fd6677f6e4f90b1dce0b762f5c0772025-01-09T06:15:18ZengElsevierOral Oncology Reports2772-90602024-03-019100193Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare casePaulo Victor Mendes Penafort0Lady Paola Aristizabal Arboleda1Sérgio Takashi Kussaba2Izilda Aparecida Cardinalli3Regina Maria Holanda de Mendonça4Márcio Ajudarte Lopes5Pablo Agustin Vargas6Alan Roger Santos-Silva7Corresponding author. Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Av. Limeira, 901, 13.414-903, Piracicaba, São Paulo (SP), Brazil.; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, BrazilOral Diagnosis Department, Piracicaba Dental School, University of Campinas, BrazilCathedral College, Boa Vista, RR, BrazilBoldrini Children's Hospital, Campinas, SP, BrazilBoldrini Children's Hospital, Campinas, SP, BrazilOral Diagnosis Department, Piracicaba Dental School, University of Campinas, BrazilOral Diagnosis Department, Piracicaba Dental School, University of Campinas, BrazilOral Diagnosis Department, Piracicaba Dental School, University of Campinas, BrazilB-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) is a type of malignancy involving uncontrolled proliferation of B-precursor lymphoid cells. This case report delineates B-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) manifesting in the mandible and medullary regions of a 10-year-old female. Clinically, an irregular swelling with bone cortical destruction and weight loss was observed. Histopathological examination revealed proliferation of CD10, CD43, CD79a, PAX-5, TDT, CD99, and FLI-1 positive small round blue cells, with a 49% lymphoblast infiltration in the bone marrow. Chemotherapy was administered, leading to disease control during the 5-year follow-up.http://www.sciencedirect.com/science/article/pii/S2772906024000396 |
| spellingShingle | Paulo Victor Mendes Penafort Lady Paola Aristizabal Arboleda Sérgio Takashi Kussaba Izilda Aparecida Cardinalli Regina Maria Holanda de Mendonça Márcio Ajudarte Lopes Pablo Agustin Vargas Alan Roger Santos-Silva Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare case Oral Oncology Reports |
| title | Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare case |
| title_full | Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare case |
| title_fullStr | Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare case |
| title_full_unstemmed | Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare case |
| title_short | Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare case |
| title_sort | mandible infiltration as a clinical signal of extramedullary b cell acute lymphoblastic leukemia lymphoma in a child report of a rare case |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024000396 |
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