Advances in Contraceptive Vaccine Development: A Comprehensive Review
The issues of uncontrolled global population growth and unintended pregnancies are severe, and the existing contraceptive methods have numerous limitations, making the development of novel contraceptive technologies urgent. Contraceptive vaccines offer a promising alternative to traditional contrace...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/13/7/692 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849251951742550016 |
|---|---|
| author | Wen Gao Xiaoting Shen Peipei Li Chanchan Xiao Yongxia Wang |
| author_facet | Wen Gao Xiaoting Shen Peipei Li Chanchan Xiao Yongxia Wang |
| author_sort | Wen Gao |
| collection | DOAJ |
| description | The issues of uncontrolled global population growth and unintended pregnancies are severe, and the existing contraceptive methods have numerous limitations, making the development of novel contraceptive technologies urgent. Contraceptive vaccines offer a promising alternative to traditional contraception methods. This article reviews the three developmental stages of contraceptive vaccines, including early exploration, technical bottlenecks, and innovative development directions in the new era. This article also summarizes the targets of immunocontraception, covering the current research status of contraceptive vaccines targeting sperm production, sperm antigens, oocyte zona pellucida, and gamete outcomes. Furthermore, this article explores the advantages of contraceptive vaccines in terms of efficiency, non-invasiveness, reversibility, and the promotion of gender equality. Challenges associated with clinical translation and real-world implementation are also critically analyzed. |
| format | Article |
| id | doaj-art-c48632bd6dd54f55bc5ae4941881bc34 |
| institution | Kabale University |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-c48632bd6dd54f55bc5ae4941881bc342025-08-20T03:56:46ZengMDPI AGVaccines2076-393X2025-06-0113769210.3390/vaccines13070692Advances in Contraceptive Vaccine Development: A Comprehensive ReviewWen Gao0Xiaoting Shen1Peipei Li2Chanchan Xiao3Yongxia Wang4NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou 510600, ChinaNHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou 510600, ChinaNHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou 510600, ChinaThe Affiliated Hospital of Xiangnan University, Chenzhou 423000, ChinaNHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou 510600, ChinaThe issues of uncontrolled global population growth and unintended pregnancies are severe, and the existing contraceptive methods have numerous limitations, making the development of novel contraceptive technologies urgent. Contraceptive vaccines offer a promising alternative to traditional contraception methods. This article reviews the three developmental stages of contraceptive vaccines, including early exploration, technical bottlenecks, and innovative development directions in the new era. This article also summarizes the targets of immunocontraception, covering the current research status of contraceptive vaccines targeting sperm production, sperm antigens, oocyte zona pellucida, and gamete outcomes. Furthermore, this article explores the advantages of contraceptive vaccines in terms of efficiency, non-invasiveness, reversibility, and the promotion of gender equality. Challenges associated with clinical translation and real-world implementation are also critically analyzed.https://www.mdpi.com/2076-393X/13/7/692contraceptive vaccinesimmunocontraceptionsperm productionsperm antigenszona pellucida of oocytesgamete outcomes |
| spellingShingle | Wen Gao Xiaoting Shen Peipei Li Chanchan Xiao Yongxia Wang Advances in Contraceptive Vaccine Development: A Comprehensive Review Vaccines contraceptive vaccines immunocontraception sperm production sperm antigens zona pellucida of oocytes gamete outcomes |
| title | Advances in Contraceptive Vaccine Development: A Comprehensive Review |
| title_full | Advances in Contraceptive Vaccine Development: A Comprehensive Review |
| title_fullStr | Advances in Contraceptive Vaccine Development: A Comprehensive Review |
| title_full_unstemmed | Advances in Contraceptive Vaccine Development: A Comprehensive Review |
| title_short | Advances in Contraceptive Vaccine Development: A Comprehensive Review |
| title_sort | advances in contraceptive vaccine development a comprehensive review |
| topic | contraceptive vaccines immunocontraception sperm production sperm antigens zona pellucida of oocytes gamete outcomes |
| url | https://www.mdpi.com/2076-393X/13/7/692 |
| work_keys_str_mv | AT wengao advancesincontraceptivevaccinedevelopmentacomprehensivereview AT xiaotingshen advancesincontraceptivevaccinedevelopmentacomprehensivereview AT peipeili advancesincontraceptivevaccinedevelopmentacomprehensivereview AT chanchanxiao advancesincontraceptivevaccinedevelopmentacomprehensivereview AT yongxiawang advancesincontraceptivevaccinedevelopmentacomprehensivereview |