Vitamin D deficiency at the time of delivery - Prevalence and risk of postpartum infections.
<h4>Background</h4>Postpartum infections are a common cause of morbidity after childbirth. Vitamin D deficiency has been shown to increase the risk for several infections in a non-pregnant population. Vitamin D deficiency has been described as common in pregnant women.<h4>Objective...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226673&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850043143042367488 |
|---|---|
| author | Daniel Axelsson Jan Brynhildsen Marie Blomberg |
| author_facet | Daniel Axelsson Jan Brynhildsen Marie Blomberg |
| author_sort | Daniel Axelsson |
| collection | DOAJ |
| description | <h4>Background</h4>Postpartum infections are a common cause of morbidity after childbirth. Vitamin D deficiency has been shown to increase the risk for several infections in a non-pregnant population. Vitamin D deficiency has been described as common in pregnant women.<h4>Objective</h4>To investigate whether vitamin D deficiency in pregnant women in labor was associated with an increased risk of overall postpartum infectious morbidity within eight weeks of delivery. A secondary aim was to estimate the prevalence of vitamin D deficiency among pregnant women in Linköping, Sweden at the time of delivery.<h4>Material and methods</h4>Serum vitamin D levels in labor were analyzed for 1397 women. Vitamin D deficiency was defined as serum levels <50 nmol/L. All ICD-10 codes given to the women eight weeks postpartum were reviewed and postpartum infections were defined as the presence of an ICD-10 code suggestive of infection. The prevalence of postpartum infections among women with sufficient vitamin D levels was compared with women with vitamin D deficiency. Adjusted Odds Ratios and 95% confidence intervals for postpartum infections were calculated using multivariate logistic regression analysis.<h4>Results</h4>Fifty eight per cent of the women had serum vitamin D levels <50 nmol/L. The proportion of women with vitamin D deficiency varied, as expected, with season. No association between vitamin D deficiency and postpartum infections was found. For vitamin D 25-50 nmol/L the adjusted Odds Ratio was 0.85 (95% confidence interval 0.56-1.29) and for vitamin D <25 nmol/L the adjusted Odds Ratio was 1.15 (95% confidence interval 0.66-2.03). Women who smoked or who had a cesarean section had an increased risk of postpartum infections.<h4>Conclusions</h4>Vitamin D deficiency was more common than previously reported in Swedish pregnant women. No association between vitamin D deficiency and postpartum infections was found. Other well-known risk factors for postpartum infection were identified. |
| format | Article |
| id | doaj-art-c47e9cb5897f4318a67a7305c62ddd44 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c47e9cb5897f4318a67a7305c62ddd442025-08-20T02:55:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-011412e022667310.1371/journal.pone.0226673Vitamin D deficiency at the time of delivery - Prevalence and risk of postpartum infections.Daniel AxelssonJan BrynhildsenMarie Blomberg<h4>Background</h4>Postpartum infections are a common cause of morbidity after childbirth. Vitamin D deficiency has been shown to increase the risk for several infections in a non-pregnant population. Vitamin D deficiency has been described as common in pregnant women.<h4>Objective</h4>To investigate whether vitamin D deficiency in pregnant women in labor was associated with an increased risk of overall postpartum infectious morbidity within eight weeks of delivery. A secondary aim was to estimate the prevalence of vitamin D deficiency among pregnant women in Linköping, Sweden at the time of delivery.<h4>Material and methods</h4>Serum vitamin D levels in labor were analyzed for 1397 women. Vitamin D deficiency was defined as serum levels <50 nmol/L. All ICD-10 codes given to the women eight weeks postpartum were reviewed and postpartum infections were defined as the presence of an ICD-10 code suggestive of infection. The prevalence of postpartum infections among women with sufficient vitamin D levels was compared with women with vitamin D deficiency. Adjusted Odds Ratios and 95% confidence intervals for postpartum infections were calculated using multivariate logistic regression analysis.<h4>Results</h4>Fifty eight per cent of the women had serum vitamin D levels <50 nmol/L. The proportion of women with vitamin D deficiency varied, as expected, with season. No association between vitamin D deficiency and postpartum infections was found. For vitamin D 25-50 nmol/L the adjusted Odds Ratio was 0.85 (95% confidence interval 0.56-1.29) and for vitamin D <25 nmol/L the adjusted Odds Ratio was 1.15 (95% confidence interval 0.66-2.03). Women who smoked or who had a cesarean section had an increased risk of postpartum infections.<h4>Conclusions</h4>Vitamin D deficiency was more common than previously reported in Swedish pregnant women. No association between vitamin D deficiency and postpartum infections was found. Other well-known risk factors for postpartum infection were identified.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226673&type=printable |
| spellingShingle | Daniel Axelsson Jan Brynhildsen Marie Blomberg Vitamin D deficiency at the time of delivery - Prevalence and risk of postpartum infections. PLoS ONE |
| title | Vitamin D deficiency at the time of delivery - Prevalence and risk of postpartum infections. |
| title_full | Vitamin D deficiency at the time of delivery - Prevalence and risk of postpartum infections. |
| title_fullStr | Vitamin D deficiency at the time of delivery - Prevalence and risk of postpartum infections. |
| title_full_unstemmed | Vitamin D deficiency at the time of delivery - Prevalence and risk of postpartum infections. |
| title_short | Vitamin D deficiency at the time of delivery - Prevalence and risk of postpartum infections. |
| title_sort | vitamin d deficiency at the time of delivery prevalence and risk of postpartum infections |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226673&type=printable |
| work_keys_str_mv | AT danielaxelsson vitaminddeficiencyatthetimeofdeliveryprevalenceandriskofpostpartuminfections AT janbrynhildsen vitaminddeficiencyatthetimeofdeliveryprevalenceandriskofpostpartuminfections AT marieblomberg vitaminddeficiencyatthetimeofdeliveryprevalenceandriskofpostpartuminfections |