Genetic Predisposition and Mitochondrial Dysfunction in Sudden Cardiac Death: Role of MCU Complex Genetic Variations

Genetic Predisposition and Mitochondrial Dysfunction in Sudden Cardiac Death: Role of MCU Complex Genetic Variations

Sudden cardiac death (SCD) is a major cause of cardiovascular mortality, with coronary artery disease-related SCD (SCD-CAD) being the most prevalent form. Genetic factors and mitochondrial dysfunction, particularly in calcium homeostasis, are critical in SCD-CAD. However, the specific genetic factor...

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Bibliographic Details
Main Authors: Haoliang Meng, Yan He, Yukun Rui, Mengqi Cai, Dongke Fu, Wanli Bi, Bin Luo, Yuzhen Gao
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
sudden cardiac death
coronary artery disease
mitochondrial calcium uniporter (MCU)
indel variant
<i>SMDT1</i>
Online Access:https://www.mdpi.com/2073-4409/14/10/728
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