Global, regional, and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040
Introduction Smoking is a major environmental risk factor for nasopharyngeal carcinoma (NPC), but the global burden and epidemiological trends of NPC attributable to smoking remain unclear. Methods Data were obtained from the 2021 Global Burden of Disease study. A comprehensive analysis was conduct...
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European Publishing
2025-06-01
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| Series: | Tobacco Induced Diseases |
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| Online Access: | https://www.tobaccoinduceddiseases.org/Global-regional-and-national-temporal-trends-in-mortality-and-disease-burden-of-nasopharyngeal,204742,0,2.html |
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| _version_ | 1849423193775800320 |
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| author | Defeng Liu Lulu Zhuang Yueze Li Jinming Yu Minghuan Li |
| author_facet | Defeng Liu Lulu Zhuang Yueze Li Jinming Yu Minghuan Li |
| author_sort | Defeng Liu |
| collection | DOAJ |
| description | Introduction
Smoking is a major environmental risk factor for nasopharyngeal
carcinoma (NPC), but the global burden and epidemiological trends of NPC
attributable to smoking remain unclear.
Methods
Data were obtained from the 2021 Global Burden of Disease study. A
comprehensive analysis was conducted on mortality, years lived with disability
(YLDs), years of life lost (YLLs), disability-adjusted life years (DALYs) attributable
to NPC attributable to smoking. Clustering analysis was applied to evaluate the
variation patterns across 21 regions. The NORDPRED age-period-cohort model
was used for prediction.
Results
In 2021, there were 13410 deaths globally from NPC attributable to smoking,
10031 YLDs, 1379583 YLLs, and 389614 DALYs. The disease burden was most
severe in Asia. Males bore a significantly higher burden than females, mainly
concentrated in middle-aged and older populations. From 1990 to 2021, although
the number of cases increased, ASRs showed a marked decline, particularly among
females and in regions with both high and low sociodemographic index (SDI)
levels. Regional analyses revealed significant reductions of the disease burden in
Australasia and Western Europe. The 21 regions were divided into 4 groups based
on changes in mortality, representing distinct variation patterns. Projections from
2022 to 2040 indicate that, while the total number of deaths and disease burden
is expected to rise, ASRs are anticipated to decline except YLDs.
Conclusions
Smoking contributes significantly to the disease burden of NPC,
posing a serious threat to public health. Targeted intervention strategies should
be implemented according to the regional clustering results of disease burden. |
| format | Article |
| id | doaj-art-c4796d195ca64407b76c9e71ffb152ec |
| institution | Kabale University |
| issn | 1617-9625 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj-art-c4796d195ca64407b76c9e71ffb152ec2025-08-20T03:30:44ZengEuropean PublishingTobacco Induced Diseases1617-96252025-06-0123June11410.18332/tid/204742204742Global, regional, and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040Defeng Liu0Lulu Zhuang1Yueze Li2Jinming Yu3Minghuan Li4https://orcid.org/0000-0001-6112-7038Cheeloo College of Medicine, Shandong University, Jinan, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaIntroduction Smoking is a major environmental risk factor for nasopharyngeal carcinoma (NPC), but the global burden and epidemiological trends of NPC attributable to smoking remain unclear. Methods Data were obtained from the 2021 Global Burden of Disease study. A comprehensive analysis was conducted on mortality, years lived with disability (YLDs), years of life lost (YLLs), disability-adjusted life years (DALYs) attributable to NPC attributable to smoking. Clustering analysis was applied to evaluate the variation patterns across 21 regions. The NORDPRED age-period-cohort model was used for prediction. Results In 2021, there were 13410 deaths globally from NPC attributable to smoking, 10031 YLDs, 1379583 YLLs, and 389614 DALYs. The disease burden was most severe in Asia. Males bore a significantly higher burden than females, mainly concentrated in middle-aged and older populations. From 1990 to 2021, although the number of cases increased, ASRs showed a marked decline, particularly among females and in regions with both high and low sociodemographic index (SDI) levels. Regional analyses revealed significant reductions of the disease burden in Australasia and Western Europe. The 21 regions were divided into 4 groups based on changes in mortality, representing distinct variation patterns. Projections from 2022 to 2040 indicate that, while the total number of deaths and disease burden is expected to rise, ASRs are anticipated to decline except YLDs. Conclusions Smoking contributes significantly to the disease burden of NPC, posing a serious threat to public health. Targeted intervention strategies should be implemented according to the regional clustering results of disease burden.https://www.tobaccoinduceddiseases.org/Global-regional-and-national-temporal-trends-in-mortality-and-disease-burden-of-nasopharyngeal,204742,0,2.htmlsmokingnasopharyngeal carcinomadeathdisease burdenepidemiology |
| spellingShingle | Defeng Liu Lulu Zhuang Yueze Li Jinming Yu Minghuan Li Global, regional, and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040 Tobacco Induced Diseases smoking nasopharyngeal carcinoma death disease burden epidemiology |
| title | Global, regional, and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040 |
| title_full | Global, regional, and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040 |
| title_fullStr | Global, regional, and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040 |
| title_full_unstemmed | Global, regional, and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040 |
| title_short | Global, regional, and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040 |
| title_sort | global regional and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040 |
| topic | smoking nasopharyngeal carcinoma death disease burden epidemiology |
| url | https://www.tobaccoinduceddiseases.org/Global-regional-and-national-temporal-trends-in-mortality-and-disease-burden-of-nasopharyngeal,204742,0,2.html |
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