An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery
Naphthylimides play a pivotal role as aromatic heterocyclic compounds, serving as the foundational structures for numerous pharmacologically significant drugs. These drugs encompass antibacterial, antifungal, anticancer, antimalarial, antiviral, anti-inflammatory, antithrombotic, and antiprotozoal a...
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| Language: | English |
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MDPI AG
2024-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/19/4529 |
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| author | Wei Ruan Zhouling Xie Ying Wang Lulu Xia Yuping Guo Dan Qiao |
| author_facet | Wei Ruan Zhouling Xie Ying Wang Lulu Xia Yuping Guo Dan Qiao |
| author_sort | Wei Ruan |
| collection | DOAJ |
| description | Naphthylimides play a pivotal role as aromatic heterocyclic compounds, serving as the foundational structures for numerous pharmacologically significant drugs. These drugs encompass antibacterial, antifungal, anticancer, antimalarial, antiviral, anti-inflammatory, antithrombotic, and antiprotozoal agents. The planar and heteroaromatic characteristics of naphthylimides grant them a strong ability to intercalate into DNA. This intercalation property renders naphthylimide derivatives highly valuable for various biological activities. The advantageous pharmacological activity and ease of synthesis associated with naphthylimides and their derivatives provide significant benefits in the design and development of new compounds within this class. Currently, only a few such molecules are undergoing preclinical and clinical evaluations. In this paper, we have compiled the literature on naphthylimides reported by researchers from 2006 to 2024. Our focus lies on exploring the pharmacological activities of their analogues from a drug development and discovery perspective, while examining their structure–activity relationship and mechanisms of action. |
| format | Article |
| id | doaj-art-c46d819eff71443aac43aa1fcabe7f3e |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-c46d819eff71443aac43aa1fcabe7f3e2025-08-20T02:16:54ZengMDPI AGMolecules1420-30492024-09-012919452910.3390/molecules29194529An Overview of Naphthylimide as Specific Scaffold for New Drug DiscoveryWei Ruan0Zhouling Xie1Ying Wang2Lulu Xia3Yuping Guo4Dan Qiao5School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, ChinaSchool of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, ChinaSchool of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, ChinaSchool of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, ChinaSchool of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, ChinaSchool of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, ChinaNaphthylimides play a pivotal role as aromatic heterocyclic compounds, serving as the foundational structures for numerous pharmacologically significant drugs. These drugs encompass antibacterial, antifungal, anticancer, antimalarial, antiviral, anti-inflammatory, antithrombotic, and antiprotozoal agents. The planar and heteroaromatic characteristics of naphthylimides grant them a strong ability to intercalate into DNA. This intercalation property renders naphthylimide derivatives highly valuable for various biological activities. The advantageous pharmacological activity and ease of synthesis associated with naphthylimides and their derivatives provide significant benefits in the design and development of new compounds within this class. Currently, only a few such molecules are undergoing preclinical and clinical evaluations. In this paper, we have compiled the literature on naphthylimides reported by researchers from 2006 to 2024. Our focus lies on exploring the pharmacological activities of their analogues from a drug development and discovery perspective, while examining their structure–activity relationship and mechanisms of action.https://www.mdpi.com/1420-3049/29/19/4529naphtylimideantibacterialantifungalanticancerantiviralbiological activity |
| spellingShingle | Wei Ruan Zhouling Xie Ying Wang Lulu Xia Yuping Guo Dan Qiao An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery Molecules naphtylimide antibacterial antifungal anticancer antiviral biological activity |
| title | An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery |
| title_full | An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery |
| title_fullStr | An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery |
| title_full_unstemmed | An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery |
| title_short | An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery |
| title_sort | overview of naphthylimide as specific scaffold for new drug discovery |
| topic | naphtylimide antibacterial antifungal anticancer antiviral biological activity |
| url | https://www.mdpi.com/1420-3049/29/19/4529 |
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