Pharmacological prolyl hydroxylase inhibition enhances high‐intensity exercise capacity in mice

Pharmacological prolyl hydroxylase inhibition enhances high‐intensity exercise capacity in mice

Abstract Increased blood hemoglobin concentration theoretically promotes oxygen delivery to the periphery. Clinically, in addition to recombinant human erythropoietin analogs, prolyl hydroxylase (PH) inhibitors to stabilize the expression of hypoxia‐inducible factor (HIF) protein were recently appro...

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Bibliographic Details
Main Authors: Koji Takemura, Motoki Odawara, Hiroshi Nishi, Takaaki Higashihara, Yoko Yoshida, Koichi Nakazato, Nobuharu L. Fujii, Naokata Ishii, Reiko Inagi, Tetsuhiro Tanaka, Masaomi Nangaku
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Physiological Reports
Subjects:
anemia
exercise capacity
hemoglobin
skeletal muscle
Online Access:https://doi.org/10.14814/phy2.70464
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