Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review
Abstract Engaging in activity has proven to have beneficial effects on different facets of well-being, such as conditions related to the deterioration of the nervous system. Non-coding RNAs (ncRNAs) and exosomal ncRNAs associated with vesicles have been recognized as influencers of gene expression a...
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BMC
2025-02-01
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| Series: | Molecular Medicine |
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| Online Access: | https://doi.org/10.1186/s10020-025-01091-y |
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| author | Shangwu Liu Runhong Zhang Jamal Hallajzadeh |
| author_facet | Shangwu Liu Runhong Zhang Jamal Hallajzadeh |
| author_sort | Shangwu Liu |
| collection | DOAJ |
| description | Abstract Engaging in activity has proven to have beneficial effects on different facets of well-being, such as conditions related to the deterioration of the nervous system. Non-coding RNAs (ncRNAs) and exosomal ncRNAs associated with vesicles have been recognized as influencers of gene expression and cell signaling, potentially contributing to the positive impact of physical activity on neurodegenerative conditions. It is hypothesized that exercise-induced changes in ncRNA expression may regulate key processes involved in neuroprotection, including neuroinflammation, oxidative stress, protein aggregation, and synaptic function. Exercise has shown promise in preventing neurodegenerative diseases (NDs), and ncRNAs and exosomal ncRNAs are emerging as potential mediators of these benefits. In review, we explored how ncRNAs and exosomal ncRNAs play a role in enhancing the impacts of activity on neurodegenerative disorders for future treatments. Research studies, both preclinical and clinical, that have documented the use of various exercises and their effects on ncRNAs and exosomal ncRNAs for the treatment of NDs have been compiled and enlisted from the PubMed database, spanning the time period from the year 2000 up to the current time. Studies show that manipulating specific ncRNAs or harnessing exercise-induced changes in ncRNA expression and exosomal cargo could potentially be utilized as therapeutic strategies for preventing or treating NDs. In conclusion, studies suggest that various exercise modalities, including aerobic, resistance, and high-intensity interval training, can modulate the expression of ncRNAs and exosomal ncRNAs in the context of NDs. The altered ncRNA profiles may contribute to the neuroprotective and therapeutic effects observed with exercise interventions. However, more research is needed to fully understand the underlying mechanisms and to further explore the potential of exercise-induced ncRNA signatures as biomarkers and therapeutic targets for neurodegenerative disorders. |
| format | Article |
| id | doaj-art-c46581c15bf84f5e96fef0b13ef023af |
| institution | Kabale University |
| issn | 1528-3658 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | Molecular Medicine |
| spelling | doaj-art-c46581c15bf84f5e96fef0b13ef023af2025-02-09T12:42:08ZengBMCMolecular Medicine1528-36582025-02-0131112710.1186/s10020-025-01091-yRole of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative reviewShangwu Liu0Runhong Zhang1Jamal Hallajzadeh2Department of Physical Education, Lyuliang UniversityDepartment of Physical Education, Lyuliang UniversityResearch Center for Evidence-Based Health Management, Maragheh University of Medical SciencesAbstract Engaging in activity has proven to have beneficial effects on different facets of well-being, such as conditions related to the deterioration of the nervous system. Non-coding RNAs (ncRNAs) and exosomal ncRNAs associated with vesicles have been recognized as influencers of gene expression and cell signaling, potentially contributing to the positive impact of physical activity on neurodegenerative conditions. It is hypothesized that exercise-induced changes in ncRNA expression may regulate key processes involved in neuroprotection, including neuroinflammation, oxidative stress, protein aggregation, and synaptic function. Exercise has shown promise in preventing neurodegenerative diseases (NDs), and ncRNAs and exosomal ncRNAs are emerging as potential mediators of these benefits. In review, we explored how ncRNAs and exosomal ncRNAs play a role in enhancing the impacts of activity on neurodegenerative disorders for future treatments. Research studies, both preclinical and clinical, that have documented the use of various exercises and their effects on ncRNAs and exosomal ncRNAs for the treatment of NDs have been compiled and enlisted from the PubMed database, spanning the time period from the year 2000 up to the current time. Studies show that manipulating specific ncRNAs or harnessing exercise-induced changes in ncRNA expression and exosomal cargo could potentially be utilized as therapeutic strategies for preventing or treating NDs. In conclusion, studies suggest that various exercise modalities, including aerobic, resistance, and high-intensity interval training, can modulate the expression of ncRNAs and exosomal ncRNAs in the context of NDs. The altered ncRNA profiles may contribute to the neuroprotective and therapeutic effects observed with exercise interventions. However, more research is needed to fully understand the underlying mechanisms and to further explore the potential of exercise-induced ncRNA signatures as biomarkers and therapeutic targets for neurodegenerative disorders.https://doi.org/10.1186/s10020-025-01091-yExerciseNeurodegenerative diseasesNon-coding RNAsSynaptic functionCell signaling |
| spellingShingle | Shangwu Liu Runhong Zhang Jamal Hallajzadeh Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review Molecular Medicine Exercise Neurodegenerative diseases Non-coding RNAs Synaptic function Cell signaling |
| title | Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review |
| title_full | Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review |
| title_fullStr | Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review |
| title_full_unstemmed | Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review |
| title_short | Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review |
| title_sort | role of exercise on ncrnas and exosomal ncrnas in preventing neurodegenerative diseases a narrative review |
| topic | Exercise Neurodegenerative diseases Non-coding RNAs Synaptic function Cell signaling |
| url | https://doi.org/10.1186/s10020-025-01091-y |
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