Pelota: A double-edged sword in virus infection.
Pelota, a conserved ribosome rescue factor involved in mRNA surveillance, has emerged as a pivotal player in host-virus arms race. Beyond its canonical role in maintaining translational fidelity via No-Go Decay and Non-Stop Decay pathways, Pelota exhibits a dual function during viral infection-servi...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-07-01
|
| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1013328 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849318420117454848 |
|---|---|
| author | Xue Li Xueping Zhou Fangfang Li |
| author_facet | Xue Li Xueping Zhou Fangfang Li |
| author_sort | Xue Li |
| collection | DOAJ |
| description | Pelota, a conserved ribosome rescue factor involved in mRNA surveillance, has emerged as a pivotal player in host-virus arms race. Beyond its canonical role in maintaining translational fidelity via No-Go Decay and Non-Stop Decay pathways, Pelota exhibits a dual function during viral infection-serving either as a restriction factor or as a susceptibility element depending on the virus species and their hosts. In DNA virus infections, notably with geminiviruses, a natural mutation in Pelota confers recessive resistance in tomato and pepper probably by impairing viral protein translation, offering valuable insights for resistance breeding. Conversely, in RNA virus infections, Pelota usually restricts viral propagation through RNA quality control, yet can also promote viral replication by facilitating ribosome recycling and translation. This paradox reflects a fine-tuned balance in host-virus adaption and co-evolution. Additionally, pelota mutations can modulate immune signaling pathways, with some alleles triggering enhanced resistance or autoimmunity phenotypes in plants. Meanwhile, viruses have evolved counterdefense strategies, including targeted degradation or SUMOylation interference, to subvert the Pelota's function. Together, these findings position Pelota as a double-edged sword in viral infection, highlighting its potential as a novel target for antiviral strategies through precise genetic manipulation. |
| format | Article |
| id | doaj-art-c45db071472444bb99a436f1f3f66ac8 |
| institution | Kabale University |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-c45db071472444bb99a436f1f3f66ac82025-08-20T03:50:49ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742025-07-01217e101332810.1371/journal.ppat.1013328Pelota: A double-edged sword in virus infection.Xue LiXueping ZhouFangfang LiPelota, a conserved ribosome rescue factor involved in mRNA surveillance, has emerged as a pivotal player in host-virus arms race. Beyond its canonical role in maintaining translational fidelity via No-Go Decay and Non-Stop Decay pathways, Pelota exhibits a dual function during viral infection-serving either as a restriction factor or as a susceptibility element depending on the virus species and their hosts. In DNA virus infections, notably with geminiviruses, a natural mutation in Pelota confers recessive resistance in tomato and pepper probably by impairing viral protein translation, offering valuable insights for resistance breeding. Conversely, in RNA virus infections, Pelota usually restricts viral propagation through RNA quality control, yet can also promote viral replication by facilitating ribosome recycling and translation. This paradox reflects a fine-tuned balance in host-virus adaption and co-evolution. Additionally, pelota mutations can modulate immune signaling pathways, with some alleles triggering enhanced resistance or autoimmunity phenotypes in plants. Meanwhile, viruses have evolved counterdefense strategies, including targeted degradation or SUMOylation interference, to subvert the Pelota's function. Together, these findings position Pelota as a double-edged sword in viral infection, highlighting its potential as a novel target for antiviral strategies through precise genetic manipulation.https://doi.org/10.1371/journal.ppat.1013328 |
| spellingShingle | Xue Li Xueping Zhou Fangfang Li Pelota: A double-edged sword in virus infection. PLoS Pathogens |
| title | Pelota: A double-edged sword in virus infection. |
| title_full | Pelota: A double-edged sword in virus infection. |
| title_fullStr | Pelota: A double-edged sword in virus infection. |
| title_full_unstemmed | Pelota: A double-edged sword in virus infection. |
| title_short | Pelota: A double-edged sword in virus infection. |
| title_sort | pelota a double edged sword in virus infection |
| url | https://doi.org/10.1371/journal.ppat.1013328 |
| work_keys_str_mv | AT xueli pelotaadoubleedgedswordinvirusinfection AT xuepingzhou pelotaadoubleedgedswordinvirusinfection AT fangfangli pelotaadoubleedgedswordinvirusinfection |