Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management
The coexistence of thyroid functioning nodules and Graves’ disease is called Marine-Lenhart syndrome. This condition is estimated to occur in 0.8-2.7% of patients with Graves’ disease with few cases reported in the literature. Criteria for the diagnosis are not well defined. Here, we present a case...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/3268010 |
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| _version_ | 1832556774171869184 |
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| author | Danielle Neuman Russ Kuker Francesco Vendrame |
| author_facet | Danielle Neuman Russ Kuker Francesco Vendrame |
| author_sort | Danielle Neuman |
| collection | DOAJ |
| description | The coexistence of thyroid functioning nodules and Graves’ disease is called Marine-Lenhart syndrome. This condition is estimated to occur in 0.8-2.7% of patients with Graves’ disease with few cases reported in the literature. Criteria for the diagnosis are not well defined. Here, we present a case of hyperthyroidism characterized by the presence of stimulating TSH receptor antibodies and severe bilateral exophthalmos. A thyroid uptake and scan revealed an elevated 24-hour iodine-131 uptake and a discrete hot nodule in the upper pole of the right lobe which was also observed with a thyroid ultrasound. The patient was diagnosed with Marine-Lenhart syndrome complicated by thyroid eye disease and was treated with methimazole followed by thyroidectomy and orbital decompression. We review the existing literature and propose criteria for the diagnosis and treatment of this condition. |
| format | Article |
| id | doaj-art-c44e399dfc1841fe8a903626c491dd25 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-c44e399dfc1841fe8a903626c491dd252025-02-03T05:44:29ZengWileyCase Reports in Endocrinology2090-65012090-651X2018-01-01201810.1155/2018/32680103268010Marine-Lenhart Syndrome: Case Report, Diagnosis, and ManagementDanielle Neuman0Russ Kuker1Francesco Vendrame2Division of Internal Medicine, Department of Medicine, University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, FL, USADivision of Nuclear Medicine, Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USADivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USAThe coexistence of thyroid functioning nodules and Graves’ disease is called Marine-Lenhart syndrome. This condition is estimated to occur in 0.8-2.7% of patients with Graves’ disease with few cases reported in the literature. Criteria for the diagnosis are not well defined. Here, we present a case of hyperthyroidism characterized by the presence of stimulating TSH receptor antibodies and severe bilateral exophthalmos. A thyroid uptake and scan revealed an elevated 24-hour iodine-131 uptake and a discrete hot nodule in the upper pole of the right lobe which was also observed with a thyroid ultrasound. The patient was diagnosed with Marine-Lenhart syndrome complicated by thyroid eye disease and was treated with methimazole followed by thyroidectomy and orbital decompression. We review the existing literature and propose criteria for the diagnosis and treatment of this condition.http://dx.doi.org/10.1155/2018/3268010 |
| spellingShingle | Danielle Neuman Russ Kuker Francesco Vendrame Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management Case Reports in Endocrinology |
| title | Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management |
| title_full | Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management |
| title_fullStr | Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management |
| title_full_unstemmed | Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management |
| title_short | Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management |
| title_sort | marine lenhart syndrome case report diagnosis and management |
| url | http://dx.doi.org/10.1155/2018/3268010 |
| work_keys_str_mv | AT danielleneuman marinelenhartsyndromecasereportdiagnosisandmanagement AT russkuker marinelenhartsyndromecasereportdiagnosisandmanagement AT francescovendrame marinelenhartsyndromecasereportdiagnosisandmanagement |