Research progress on exosomes from different sources in osteoarthritis and cartilage injury
Abstract Exosomes are nanosized membrane vesicles secreted by cells that have garnered considerable attention in the biomedical field in recent years. Osteoarthritis (OA) is a common disabling joint disease with limited therapeutic options in clinical practice. Recent studies have shown that exosome...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-025-06000-x |
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| author | Zilong Yang Zihao Deng Wentao Gao Wei Zhang Xuxuan Fan Ke Su Zhiqin Liu |
| author_facet | Zilong Yang Zihao Deng Wentao Gao Wei Zhang Xuxuan Fan Ke Su Zhiqin Liu |
| author_sort | Zilong Yang |
| collection | DOAJ |
| description | Abstract Exosomes are nanosized membrane vesicles secreted by cells that have garnered considerable attention in the biomedical field in recent years. Osteoarthritis (OA) is a common disabling joint disease with limited therapeutic options in clinical practice. Recent studies have shown that exosomes, as crucial mediators of intercellular communication, have proven effective in treating osteoarthritis and cartilage injury in vitro and in animal models. With ongoing research, exosomes have demonstrated tremendous potential in treating and even reversing osteoarthritis and cartilage injury. They may become an emerging therapeutic strategy in the future. This review primarily discusses the composition of exosomes and explores the potential mechanisms by which exosomes from different sources influence osteoarthritis and cartilage injury in the context of ongoing advances in exosome research. Furthermore, the review highlights the progress in exosome engineering for osteoarthritis Treatment to enhance the therapeutic efficacy of exosomes. |
| format | Article |
| id | doaj-art-c44b3ebdd290408c98cb1ea08b90759e |
| institution | DOAJ |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-c44b3ebdd290408c98cb1ea08b90759e2025-08-20T03:21:06ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-06-0120111610.1186/s13018-025-06000-xResearch progress on exosomes from different sources in osteoarthritis and cartilage injuryZilong Yang0Zihao Deng1Wentao Gao2Wei Zhang3Xuxuan Fan4Ke Su5Zhiqin Liu6Jishou University Zhuzhou Clinical College, Medical College, Jishou UniversityJishou University Zhuzhou Clinical College, Medical College, Jishou UniversityTrauma Center Department Three, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South UniversityTrauma Center Department Three, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South UniversityTrauma Center Department Three, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South UniversityTrauma Center Department Three, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South UniversityTrauma Center Department Three, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South UniversityAbstract Exosomes are nanosized membrane vesicles secreted by cells that have garnered considerable attention in the biomedical field in recent years. Osteoarthritis (OA) is a common disabling joint disease with limited therapeutic options in clinical practice. Recent studies have shown that exosomes, as crucial mediators of intercellular communication, have proven effective in treating osteoarthritis and cartilage injury in vitro and in animal models. With ongoing research, exosomes have demonstrated tremendous potential in treating and even reversing osteoarthritis and cartilage injury. They may become an emerging therapeutic strategy in the future. This review primarily discusses the composition of exosomes and explores the potential mechanisms by which exosomes from different sources influence osteoarthritis and cartilage injury in the context of ongoing advances in exosome research. Furthermore, the review highlights the progress in exosome engineering for osteoarthritis Treatment to enhance the therapeutic efficacy of exosomes.https://doi.org/10.1186/s13018-025-06000-xExosomesOsteoarthritisCartilageCartilage injuryExtracellular vesiclesCell-Free therapy |
| spellingShingle | Zilong Yang Zihao Deng Wentao Gao Wei Zhang Xuxuan Fan Ke Su Zhiqin Liu Research progress on exosomes from different sources in osteoarthritis and cartilage injury Journal of Orthopaedic Surgery and Research Exosomes Osteoarthritis Cartilage Cartilage injury Extracellular vesicles Cell-Free therapy |
| title | Research progress on exosomes from different sources in osteoarthritis and cartilage injury |
| title_full | Research progress on exosomes from different sources in osteoarthritis and cartilage injury |
| title_fullStr | Research progress on exosomes from different sources in osteoarthritis and cartilage injury |
| title_full_unstemmed | Research progress on exosomes from different sources in osteoarthritis and cartilage injury |
| title_short | Research progress on exosomes from different sources in osteoarthritis and cartilage injury |
| title_sort | research progress on exosomes from different sources in osteoarthritis and cartilage injury |
| topic | Exosomes Osteoarthritis Cartilage Cartilage injury Extracellular vesicles Cell-Free therapy |
| url | https://doi.org/10.1186/s13018-025-06000-x |
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