Computed tomography guided high dose rate brachytherapy for induced oligoprogression of colorectal cancer liver metastases
Abstract Data on the efficacy of computer tomography guided brachytherapy (CT-BRT) for limited liver metastases is lacking; to assess CT-BRT’s role in inducedoligoprogression in colorectal cancer (CRC), we performed a retrospective cohort study on CRC patients with metastatic disease, treated with 2...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-09227-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849334579962314752 |
|---|---|
| author | Paweł Cisek Łukasz Kuncman Barbara Alicja Jereczek-Fossa Ewa Wojtyna Magdalena Orzechowska Sylwia Sroka Izabela Kordzińska-Cisek Jacek Fijuth Mateusz Bilski |
| author_facet | Paweł Cisek Łukasz Kuncman Barbara Alicja Jereczek-Fossa Ewa Wojtyna Magdalena Orzechowska Sylwia Sroka Izabela Kordzińska-Cisek Jacek Fijuth Mateusz Bilski |
| author_sort | Paweł Cisek |
| collection | DOAJ |
| description | Abstract Data on the efficacy of computer tomography guided brachytherapy (CT-BRT) for limited liver metastases is lacking; to assess CT-BRT’s role in inducedoligoprogression in colorectal cancer (CRC), we performed a retrospective cohort study on CRC patients with metastatic disease, treated with 2–5 lines of systemic therapy, who achieved induced oligoprogression with up to four liver metastases eligible for CTBRT. In 75 patients, median overall survival (mOS) was 17 months, and median progression-free survival (mPFS) was 10 months during a 16-month follow-up. The mOS was not dose-dependent. Complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) were found in 8, 31, 47, and 15%, respectively. The mOS in patients with CR, PR, SD, and PD was 23, 17, 14, and 11 months, respectively. Disease Control Rate (DCR) with a high dose influenced OS, while PFS was impacted by extrahepatic metastases (especially in abdominal/pelvic lymph nodes), the number of metastases, and DCR with a high dose. Treatment toxicity was very low (Grade 3—1%, > Grade 3–0%). We report the largest cohort demonstrating CT-BRT as an effective local treatment for colorectal liver metastases in induced oligoprogression, with minimal toxicity. |
| format | Article |
| id | doaj-art-c443b36dce0f4d14913f5e38b43ecb49 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-c443b36dce0f4d14913f5e38b43ecb492025-08-20T03:45:32ZengNature PortfolioScientific Reports2045-23222025-07-0115111110.1038/s41598-025-09227-0Computed tomography guided high dose rate brachytherapy for induced oligoprogression of colorectal cancer liver metastasesPaweł Cisek0Łukasz Kuncman1Barbara Alicja Jereczek-Fossa2Ewa Wojtyna3Magdalena Orzechowska4Sylwia Sroka5Izabela Kordzińska-Cisek6Jacek Fijuth7Mateusz Bilski8Department of Brachytherapy, Saint John’s Cancer CenterDepartment of Radiotherapy, Medical University of LodzDepartment of Radiation Oncology, European Institute of Oncology IRCCSDepartment of Medical Physics, Saint John’s Cancer CenterDepartment of Molecular Carcinogenesis, Medical University of LodzDepartment of Medical Physics, Saint John’s Cancer CenterDepartment of Oncology, Saint John’s Cancer CenterDepartment of Radiotherapy, Medical University of LodzDepartment of Brachytherapy, Saint John’s Cancer CenterAbstract Data on the efficacy of computer tomography guided brachytherapy (CT-BRT) for limited liver metastases is lacking; to assess CT-BRT’s role in inducedoligoprogression in colorectal cancer (CRC), we performed a retrospective cohort study on CRC patients with metastatic disease, treated with 2–5 lines of systemic therapy, who achieved induced oligoprogression with up to four liver metastases eligible for CTBRT. In 75 patients, median overall survival (mOS) was 17 months, and median progression-free survival (mPFS) was 10 months during a 16-month follow-up. The mOS was not dose-dependent. Complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) were found in 8, 31, 47, and 15%, respectively. The mOS in patients with CR, PR, SD, and PD was 23, 17, 14, and 11 months, respectively. Disease Control Rate (DCR) with a high dose influenced OS, while PFS was impacted by extrahepatic metastases (especially in abdominal/pelvic lymph nodes), the number of metastases, and DCR with a high dose. Treatment toxicity was very low (Grade 3—1%, > Grade 3–0%). We report the largest cohort demonstrating CT-BRT as an effective local treatment for colorectal liver metastases in induced oligoprogression, with minimal toxicity.https://doi.org/10.1038/s41598-025-09227-0BrachytherapyLiver metastasesOligoprogressionMetastasis-directed therapy |
| spellingShingle | Paweł Cisek Łukasz Kuncman Barbara Alicja Jereczek-Fossa Ewa Wojtyna Magdalena Orzechowska Sylwia Sroka Izabela Kordzińska-Cisek Jacek Fijuth Mateusz Bilski Computed tomography guided high dose rate brachytherapy for induced oligoprogression of colorectal cancer liver metastases Scientific Reports Brachytherapy Liver metastases Oligoprogression Metastasis-directed therapy |
| title | Computed tomography guided high dose rate brachytherapy for induced oligoprogression of colorectal cancer liver metastases |
| title_full | Computed tomography guided high dose rate brachytherapy for induced oligoprogression of colorectal cancer liver metastases |
| title_fullStr | Computed tomography guided high dose rate brachytherapy for induced oligoprogression of colorectal cancer liver metastases |
| title_full_unstemmed | Computed tomography guided high dose rate brachytherapy for induced oligoprogression of colorectal cancer liver metastases |
| title_short | Computed tomography guided high dose rate brachytherapy for induced oligoprogression of colorectal cancer liver metastases |
| title_sort | computed tomography guided high dose rate brachytherapy for induced oligoprogression of colorectal cancer liver metastases |
| topic | Brachytherapy Liver metastases Oligoprogression Metastasis-directed therapy |
| url | https://doi.org/10.1038/s41598-025-09227-0 |
| work_keys_str_mv | AT pawełcisek computedtomographyguidedhighdoseratebrachytherapyforinducedoligoprogressionofcolorectalcancerlivermetastases AT łukaszkuncman computedtomographyguidedhighdoseratebrachytherapyforinducedoligoprogressionofcolorectalcancerlivermetastases AT barbaraalicjajereczekfossa computedtomographyguidedhighdoseratebrachytherapyforinducedoligoprogressionofcolorectalcancerlivermetastases AT ewawojtyna computedtomographyguidedhighdoseratebrachytherapyforinducedoligoprogressionofcolorectalcancerlivermetastases AT magdalenaorzechowska computedtomographyguidedhighdoseratebrachytherapyforinducedoligoprogressionofcolorectalcancerlivermetastases AT sylwiasroka computedtomographyguidedhighdoseratebrachytherapyforinducedoligoprogressionofcolorectalcancerlivermetastases AT izabelakordzinskacisek computedtomographyguidedhighdoseratebrachytherapyforinducedoligoprogressionofcolorectalcancerlivermetastases AT jacekfijuth computedtomographyguidedhighdoseratebrachytherapyforinducedoligoprogressionofcolorectalcancerlivermetastases AT mateuszbilski computedtomographyguidedhighdoseratebrachytherapyforinducedoligoprogressionofcolorectalcancerlivermetastases |