Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection
Glioblastoma (GBM) is a highly malignant tumor of the central nervous system that remains intractable despite advancements in current tumor treatment modalities, including immunotherapy. In recent years, metabolic checkpoints (aberrant metabolic pathways underlying the immunosuppressive tumor microe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1462424/full |
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| author | Wenhao Li Zhihao Wang Siliang Chen Mingrong Zuo Mingrong Zuo Yufan Xiang Yunbo Yuan Yuze He Shuxin Zhang Yanhui Liu |
| author_facet | Wenhao Li Zhihao Wang Siliang Chen Mingrong Zuo Mingrong Zuo Yufan Xiang Yunbo Yuan Yuze He Shuxin Zhang Yanhui Liu |
| author_sort | Wenhao Li |
| collection | DOAJ |
| description | Glioblastoma (GBM) is a highly malignant tumor of the central nervous system that remains intractable despite advancements in current tumor treatment modalities, including immunotherapy. In recent years, metabolic checkpoints (aberrant metabolic pathways underlying the immunosuppressive tumor microenvironment) have gained attention as promising therapeutic targets and sensitive biomarkers across various cancers. Here, we briefly review the existing understanding of tumor metabolic checkpoints and their implications in the biology and management of GBM. Additionally, we discuss techniques that could evaluate metabolic checkpoints of GBM non-invasively, thereby potentially facilitating neo-adjuvant treatment and dynamic surveillance. |
| format | Article |
| id | doaj-art-c442ea6f2b6843b8a1327630c0401a38 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-c442ea6f2b6843b8a1327630c0401a382025-08-20T01:54:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-11-011410.3389/fonc.2024.14624241462424Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detectionWenhao Li0Zhihao Wang1Siliang Chen2Mingrong Zuo3Mingrong Zuo4Yufan Xiang5Yunbo Yuan6Yuze He7Shuxin Zhang8Yanhui Liu9Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Pediatric Neurosurgery, West China Second University Hospital, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaGlioblastoma (GBM) is a highly malignant tumor of the central nervous system that remains intractable despite advancements in current tumor treatment modalities, including immunotherapy. In recent years, metabolic checkpoints (aberrant metabolic pathways underlying the immunosuppressive tumor microenvironment) have gained attention as promising therapeutic targets and sensitive biomarkers across various cancers. Here, we briefly review the existing understanding of tumor metabolic checkpoints and their implications in the biology and management of GBM. Additionally, we discuss techniques that could evaluate metabolic checkpoints of GBM non-invasively, thereby potentially facilitating neo-adjuvant treatment and dynamic surveillance.https://www.frontiersin.org/articles/10.3389/fonc.2024.1462424/fullglioblastomametabolic checkpointsimmunotherapymultimodal MRIliquid biopsy |
| spellingShingle | Wenhao Li Zhihao Wang Siliang Chen Mingrong Zuo Mingrong Zuo Yufan Xiang Yunbo Yuan Yuze He Shuxin Zhang Yanhui Liu Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection Frontiers in Oncology glioblastoma metabolic checkpoints immunotherapy multimodal MRI liquid biopsy |
| title | Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection |
| title_full | Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection |
| title_fullStr | Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection |
| title_full_unstemmed | Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection |
| title_short | Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection |
| title_sort | metabolic checkpoints in glioblastomas targets for new therapies and non invasive detection |
| topic | glioblastoma metabolic checkpoints immunotherapy multimodal MRI liquid biopsy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1462424/full |
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