RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells
Abstract Gastric cancer (GC) is one of the most common malignancies worldwide, and its development is closely associated with the abnormal expression of numerous genes. RNA - binding protein with multiple splicing 2 (RBPMS2), a member of the RNA - binding protein family, has recently been found to b...
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| Format: | Article |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-01125-9 |
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| author | Nailin Zhang Lina Yan Hua Cao Nana Zhang Tong Zhang Shengjiang Guan Qiquan Liu |
| author_facet | Nailin Zhang Lina Yan Hua Cao Nana Zhang Tong Zhang Shengjiang Guan Qiquan Liu |
| author_sort | Nailin Zhang |
| collection | DOAJ |
| description | Abstract Gastric cancer (GC) is one of the most common malignancies worldwide, and its development is closely associated with the abnormal expression of numerous genes. RNA - binding protein with multiple splicing 2 (RBPMS2), a member of the RNA - binding protein family, has recently been found to be abnormally activated in GC cells. Meanwhile, pyroptosis, a form of programmed cell death, is related to tumorigenesis, development, and immune responses.This study investigated the role of the RNA - binding protein RBPMS2 in GC. It revealed the high expression of RBPMS2 in GC cells and its association with poor prognosis. RBPMS2 promoted the proliferation, invasion, and migration of GC cells while inhibiting pyroptosis by suppressing the NLR family pyrin domain containing 3 (NLRP3)/caspase − 1/gasdermin (DGSDMD) signaling pathway. Knocking out RBPMS2 activated pyroptosis, leading to cell membrane damage and increased expression of pyroptosis - related proteins. The NLRP3 inhibitor MCC950 reversed these effects, confirming the involvement of this pathway. These findings suggest that RBPMS2 may be a potential therapeutic target for inducing pyroptosis in gastric cancer cells, providing novel insights into treatment strategies for gastric cancer. |
| format | Article |
| id | doaj-art-c43b1d46fb7b4784959ee70ca5f896e2 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-c43b1d46fb7b4784959ee70ca5f896e22025-08-20T04:01:23ZengNature PortfolioScientific Reports2045-23222025-07-0115111310.1038/s41598-025-01125-9RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cellsNailin Zhang0Lina Yan1Hua Cao2Nana Zhang3Tong Zhang4Shengjiang Guan5Qiquan Liu6Department of Spleen and Stomach Diseases, Hebei Provincial Hospital of Chinese MedicineSchool of Public Health, Hebei Medicine UniversityGraduate school, Hebei University of Chinese MedicineRespiratory department, The Fourth Hospital of Hebei Medical UniversityRespiratory department, The Fourth Hospital of Hebei Medical UniversityPharmaceutical Department, Hebei Provincial Hospital of Chinese MedicineDepartment of Spleen and Stomach Diseases, Hebei Provincial Hospital of Chinese MedicineAbstract Gastric cancer (GC) is one of the most common malignancies worldwide, and its development is closely associated with the abnormal expression of numerous genes. RNA - binding protein with multiple splicing 2 (RBPMS2), a member of the RNA - binding protein family, has recently been found to be abnormally activated in GC cells. Meanwhile, pyroptosis, a form of programmed cell death, is related to tumorigenesis, development, and immune responses.This study investigated the role of the RNA - binding protein RBPMS2 in GC. It revealed the high expression of RBPMS2 in GC cells and its association with poor prognosis. RBPMS2 promoted the proliferation, invasion, and migration of GC cells while inhibiting pyroptosis by suppressing the NLR family pyrin domain containing 3 (NLRP3)/caspase − 1/gasdermin (DGSDMD) signaling pathway. Knocking out RBPMS2 activated pyroptosis, leading to cell membrane damage and increased expression of pyroptosis - related proteins. The NLRP3 inhibitor MCC950 reversed these effects, confirming the involvement of this pathway. These findings suggest that RBPMS2 may be a potential therapeutic target for inducing pyroptosis in gastric cancer cells, providing novel insights into treatment strategies for gastric cancer.https://doi.org/10.1038/s41598-025-01125-9RBPMS2Gastric cancerPyrodeathFerroptosisCell multiplicationCell migration |
| spellingShingle | Nailin Zhang Lina Yan Hua Cao Nana Zhang Tong Zhang Shengjiang Guan Qiquan Liu RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells Scientific Reports RBPMS2 Gastric cancer Pyrodeath Ferroptosis Cell multiplication Cell migration |
| title | RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells |
| title_full | RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells |
| title_fullStr | RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells |
| title_full_unstemmed | RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells |
| title_short | RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells |
| title_sort | rbpms2 can inhibit the nlrp3 caspase 1 gsdmd signaling pathway to resist pyroptosis in gastric cancer cells |
| topic | RBPMS2 Gastric cancer Pyrodeath Ferroptosis Cell multiplication Cell migration |
| url | https://doi.org/10.1038/s41598-025-01125-9 |
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