Analysis of skin and corneal fiber electrodes for electroretinogram assessments in patients with major depressive disorder
BackgroundElectroretinograms (ERG) are usually recorded with non-invasive corneal electrodes, requiring direct contact with the ocular surface. However, corneal electrode application is not tolerated by some individuals. The advent of handheld ERG devices has facilitated the use of skin electrodes f...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1501149/full |
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| author | Kathrin Nickel Ludger Tebartz van Elst Malina Beringer Dominique Endres Kimon Runge Simon Maier Sebastian Küchlin Michael Bach Katharina Domschke Katharina Domschke Sven P. Heinrich Evelyn B. N. Friedel Evelyn B. N. Friedel Evelyn B. N. Friedel |
| author_facet | Kathrin Nickel Ludger Tebartz van Elst Malina Beringer Dominique Endres Kimon Runge Simon Maier Sebastian Küchlin Michael Bach Katharina Domschke Katharina Domschke Sven P. Heinrich Evelyn B. N. Friedel Evelyn B. N. Friedel Evelyn B. N. Friedel |
| author_sort | Kathrin Nickel |
| collection | DOAJ |
| description | BackgroundElectroretinograms (ERG) are usually recorded with non-invasive corneal electrodes, requiring direct contact with the ocular surface. However, corneal electrode application is not tolerated by some individuals. The advent of handheld ERG devices has facilitated the use of skin electrodes for ERG measurements. Skin electrodes do not require corneal contact and thus enhance patient comfort, simplify the attachment process, and reduce preparation time, which is particularly beneficial for clinical psychiatric research. Nevertheless, due to the different attachment methods, ERG amplitudes recorded with skin compared to corneal electrodes are considerably smaller. However, comparative data on ERGs recorded with skin vs. corneal electrodes in psychiatric populations are currently lacking.Materials and methodsWe recorded flash electroretinograms of 57 healthy controls (HC) and 30 patients with a major depressive disorder (MDD) using both sensor strip skin and corneal electrodes with the handheld RETeval® device.ResultsThe significant reduction in both the amplitude and peak time of the a-wave in MDD when using sensor strip skin electrodes could not be replicated with corneal electrodes. Comparing both electrode types in HC revealed a fair correlation between sensor strip and corneal electrodes for a- and b-wave amplitudes and a moderate correlation for a- and b-wave peak times.ConclusionIn addition to being better tolerated, sensor strip skin electrodes appear to be more effective than corneal electrodes in detecting ERG alterations in patients with MDD when using the RETeval® device, making them a promising alternative to traditional corneal electrodes. |
| format | Article |
| id | doaj-art-c43aa23696c542368ca87f3f7be3c60e |
| institution | OA Journals |
| issn | 1662-453X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-c43aa23696c542368ca87f3f7be3c60e2025-08-20T02:23:45ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-11-011810.3389/fnins.2024.15011491501149Analysis of skin and corneal fiber electrodes for electroretinogram assessments in patients with major depressive disorderKathrin Nickel0Ludger Tebartz van Elst1Malina Beringer2Dominique Endres3Kimon Runge4Simon Maier5Sebastian Küchlin6Michael Bach7Katharina Domschke8Katharina Domschke9Sven P. Heinrich10Evelyn B. N. Friedel11Evelyn B. N. Friedel12Evelyn B. N. Friedel13Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyEye Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyEye Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyGerman Center for Mental Health (DZPG), Partner Site Berlin, Berlin, GermanyEye Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyEye Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, GermanyFaculty of Biology, University of Freiburg, Freiburg, GermanyBackgroundElectroretinograms (ERG) are usually recorded with non-invasive corneal electrodes, requiring direct contact with the ocular surface. However, corneal electrode application is not tolerated by some individuals. The advent of handheld ERG devices has facilitated the use of skin electrodes for ERG measurements. Skin electrodes do not require corneal contact and thus enhance patient comfort, simplify the attachment process, and reduce preparation time, which is particularly beneficial for clinical psychiatric research. Nevertheless, due to the different attachment methods, ERG amplitudes recorded with skin compared to corneal electrodes are considerably smaller. However, comparative data on ERGs recorded with skin vs. corneal electrodes in psychiatric populations are currently lacking.Materials and methodsWe recorded flash electroretinograms of 57 healthy controls (HC) and 30 patients with a major depressive disorder (MDD) using both sensor strip skin and corneal electrodes with the handheld RETeval® device.ResultsThe significant reduction in both the amplitude and peak time of the a-wave in MDD when using sensor strip skin electrodes could not be replicated with corneal electrodes. Comparing both electrode types in HC revealed a fair correlation between sensor strip and corneal electrodes for a- and b-wave amplitudes and a moderate correlation for a- and b-wave peak times.ConclusionIn addition to being better tolerated, sensor strip skin electrodes appear to be more effective than corneal electrodes in detecting ERG alterations in patients with MDD when using the RETeval® device, making them a promising alternative to traditional corneal electrodes.https://www.frontiersin.org/articles/10.3389/fnins.2024.1501149/fullsensor strip skin electrodesskin electrodesfiber electrodescorneal electrodesRETeval®electroretinogram |
| spellingShingle | Kathrin Nickel Ludger Tebartz van Elst Malina Beringer Dominique Endres Kimon Runge Simon Maier Sebastian Küchlin Michael Bach Katharina Domschke Katharina Domschke Sven P. Heinrich Evelyn B. N. Friedel Evelyn B. N. Friedel Evelyn B. N. Friedel Analysis of skin and corneal fiber electrodes for electroretinogram assessments in patients with major depressive disorder Frontiers in Neuroscience sensor strip skin electrodes skin electrodes fiber electrodes corneal electrodes RETeval® electroretinogram |
| title | Analysis of skin and corneal fiber electrodes for electroretinogram assessments in patients with major depressive disorder |
| title_full | Analysis of skin and corneal fiber electrodes for electroretinogram assessments in patients with major depressive disorder |
| title_fullStr | Analysis of skin and corneal fiber electrodes for electroretinogram assessments in patients with major depressive disorder |
| title_full_unstemmed | Analysis of skin and corneal fiber electrodes for electroretinogram assessments in patients with major depressive disorder |
| title_short | Analysis of skin and corneal fiber electrodes for electroretinogram assessments in patients with major depressive disorder |
| title_sort | analysis of skin and corneal fiber electrodes for electroretinogram assessments in patients with major depressive disorder |
| topic | sensor strip skin electrodes skin electrodes fiber electrodes corneal electrodes RETeval® electroretinogram |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1501149/full |
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