The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction

The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction

Summary: The partner and localizer of BRCA2 (PALB2) is a scaffold protein linking BRCA1 with BRCA2 and RAD51 during homologous recombination (HR). PALB2 interaction with DNA strongly enhances HR in cells, while the PALB2 DNA-binding domain (PALB2-DBD) supports DNA strand exchange in vitro. We determ...

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Bibliographic Details
Main Authors: Yevhenii Kyriukha, Maxwell B. Watkins, Jennifer M. Redington, Nithya Chintalapati, Abhishek Ganti, Reza Dastvan, Vladimir N. Uversky, Jesse B. Hopkins, Nicola Pozzi, Sergey Korolev
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Biochemistry
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224024842
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