Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort.
<h4>Background</h4>Modeling trajectories of decline can help describe the variability in progression of cognitive impairment in dementia. Better characterisation of these trajectories has significant implications for understanding disease progression, trial design and care planning.<h...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0178562&type=printable |
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| author | Elizabeth Baker Ehtesham Iqbal Caroline Johnston Matthew Broadbent Hitesh Shetty Robert Stewart Robert Howard Stephen Newhouse Mizanur Khondoker Richard J B Dobson |
| author_facet | Elizabeth Baker Ehtesham Iqbal Caroline Johnston Matthew Broadbent Hitesh Shetty Robert Stewart Robert Howard Stephen Newhouse Mizanur Khondoker Richard J B Dobson |
| author_sort | Elizabeth Baker |
| collection | DOAJ |
| description | <h4>Background</h4>Modeling trajectories of decline can help describe the variability in progression of cognitive impairment in dementia. Better characterisation of these trajectories has significant implications for understanding disease progression, trial design and care planning.<h4>Methods</h4>Patients with at least three Mini-mental State Examination (MMSE) scores recorded in the South London and Maudsley NHS Foundation Trust Electronic Health Records, UK were selected (N = 3441) to form a retrospective cohort. Trajectories of cognitive decline were identified through latent class growth analysis of longitudinal MMSE scores. Demographics, Health of Nation Outcome Scales and medications were compared across trajectories identified.<h4>Results</h4>Four of the six trajectories showed increased rate of decline with lower baseline MMSE. Two trajectories had similar initial MMSE scores but different rates of decline. In the faster declining trajectory of the two, a higher incidence of both behavioral problems and sertraline prescription were present.<h4>Conclusions</h4>We find suggestive evidence for association of behavioral problems and sertraline prescription with rate of decline. Further work is needed to determine whether trajectories replicate in other datasets. |
| format | Article |
| id | doaj-art-c4393ac3d3934f79b682dc1af5ae7bf2 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c4393ac3d3934f79b682dc1af5ae7bf22025-08-20T02:03:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017856210.1371/journal.pone.0178562Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort.Elizabeth BakerEhtesham IqbalCaroline JohnstonMatthew BroadbentHitesh ShettyRobert StewartRobert HowardStephen NewhouseMizanur KhondokerRichard J B Dobson<h4>Background</h4>Modeling trajectories of decline can help describe the variability in progression of cognitive impairment in dementia. Better characterisation of these trajectories has significant implications for understanding disease progression, trial design and care planning.<h4>Methods</h4>Patients with at least three Mini-mental State Examination (MMSE) scores recorded in the South London and Maudsley NHS Foundation Trust Electronic Health Records, UK were selected (N = 3441) to form a retrospective cohort. Trajectories of cognitive decline were identified through latent class growth analysis of longitudinal MMSE scores. Demographics, Health of Nation Outcome Scales and medications were compared across trajectories identified.<h4>Results</h4>Four of the six trajectories showed increased rate of decline with lower baseline MMSE. Two trajectories had similar initial MMSE scores but different rates of decline. In the faster declining trajectory of the two, a higher incidence of both behavioral problems and sertraline prescription were present.<h4>Conclusions</h4>We find suggestive evidence for association of behavioral problems and sertraline prescription with rate of decline. Further work is needed to determine whether trajectories replicate in other datasets.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0178562&type=printable |
| spellingShingle | Elizabeth Baker Ehtesham Iqbal Caroline Johnston Matthew Broadbent Hitesh Shetty Robert Stewart Robert Howard Stephen Newhouse Mizanur Khondoker Richard J B Dobson Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort. PLoS ONE |
| title | Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort. |
| title_full | Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort. |
| title_fullStr | Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort. |
| title_full_unstemmed | Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort. |
| title_short | Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort. |
| title_sort | trajectories of dementia related cognitive decline in a large mental health records derived patient cohort |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0178562&type=printable |
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