Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus

Secondary causes of minimal change disease (MCD) account for a minority of cases compared to its primary or idiopathic form and provide ground for consideration of common mechanisms of pathogenesis. In this paper we report a case of a 27-year-old Latina woman, a renal transplant recipient with syste...

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Main Authors: Elena Gkrouzman, Kyriakos A. Kirou, Surya V. Seshan, James M. Chevalier
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Case Reports in Nephrology
Online Access:http://dx.doi.org/10.1155/2015/987212
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author Elena Gkrouzman
Kyriakos A. Kirou
Surya V. Seshan
James M. Chevalier
author_facet Elena Gkrouzman
Kyriakos A. Kirou
Surya V. Seshan
James M. Chevalier
author_sort Elena Gkrouzman
collection DOAJ
description Secondary causes of minimal change disease (MCD) account for a minority of cases compared to its primary or idiopathic form and provide ground for consideration of common mechanisms of pathogenesis. In this paper we report a case of a 27-year-old Latina woman, a renal transplant recipient with systemic lupus erythematosus (SLE), who developed nephrotic range proteinuria 6 months after transplantation. The patient had recurrent acute renal failure and multiple biopsies were consistent with MCD. However, she lacked any other features of the typical nephrotic syndrome. An angiogram revealed a right external iliac vein stenosis in the region of renal vein anastomosis, which when restored resulted in normalization of creatinine and relief from proteinuria. We report a rare case of MCD developing secondary to iliac vein stenosis in a renal transplant recipient with SLE. Additionally we suggest that, in the event of biopsy-proven MCD presenting as an atypical nephrotic syndrome, alternative or secondary, potentially reversible, causes should be considered and explored.
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spelling doaj-art-c4329f4f7a0d4106b6ef3dd25fa5bd7a2025-02-03T01:03:51ZengWileyCase Reports in Nephrology2090-66412090-665X2015-01-01201510.1155/2015/987212987212Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus ErythematosusElena Gkrouzman0Kyriakos A. Kirou1Surya V. Seshan2James M. Chevalier3University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1235, USADivision of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USANew York-Presbyterian Hospital, 525 East 68th Street, Starr Pavilion 1009, New York, NY 10021, USARogosin Kidney Center, 505 East 70th Street, New York, NY 10021, USASecondary causes of minimal change disease (MCD) account for a minority of cases compared to its primary or idiopathic form and provide ground for consideration of common mechanisms of pathogenesis. In this paper we report a case of a 27-year-old Latina woman, a renal transplant recipient with systemic lupus erythematosus (SLE), who developed nephrotic range proteinuria 6 months after transplantation. The patient had recurrent acute renal failure and multiple biopsies were consistent with MCD. However, she lacked any other features of the typical nephrotic syndrome. An angiogram revealed a right external iliac vein stenosis in the region of renal vein anastomosis, which when restored resulted in normalization of creatinine and relief from proteinuria. We report a rare case of MCD developing secondary to iliac vein stenosis in a renal transplant recipient with SLE. Additionally we suggest that, in the event of biopsy-proven MCD presenting as an atypical nephrotic syndrome, alternative or secondary, potentially reversible, causes should be considered and explored.http://dx.doi.org/10.1155/2015/987212
spellingShingle Elena Gkrouzman
Kyriakos A. Kirou
Surya V. Seshan
James M. Chevalier
Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus
Case Reports in Nephrology
title Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus
title_full Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus
title_fullStr Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus
title_full_unstemmed Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus
title_short Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus
title_sort minimal change disease as a secondary and reversible event of a renal transplant case with systemic lupus erythematosus
url http://dx.doi.org/10.1155/2015/987212
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AT suryavseshan minimalchangediseaseasasecondaryandreversibleeventofarenaltransplantcasewithsystemiclupuserythematosus
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