Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus
Secondary causes of minimal change disease (MCD) account for a minority of cases compared to its primary or idiopathic form and provide ground for consideration of common mechanisms of pathogenesis. In this paper we report a case of a 27-year-old Latina woman, a renal transplant recipient with syste...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2015/987212 |
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| author | Elena Gkrouzman Kyriakos A. Kirou Surya V. Seshan James M. Chevalier |
| author_facet | Elena Gkrouzman Kyriakos A. Kirou Surya V. Seshan James M. Chevalier |
| author_sort | Elena Gkrouzman |
| collection | DOAJ |
| description | Secondary causes of minimal change disease (MCD) account for a minority of cases compared to its primary or idiopathic form and provide ground for consideration of common mechanisms of pathogenesis. In this paper we report a case of a 27-year-old Latina woman, a renal transplant recipient with systemic lupus erythematosus (SLE), who developed nephrotic range proteinuria 6 months after transplantation. The patient had recurrent acute renal failure and multiple biopsies were consistent with MCD. However, she lacked any other features of the typical nephrotic syndrome. An angiogram revealed a right external iliac vein stenosis in the region of renal vein anastomosis, which when restored resulted in normalization of creatinine and relief from proteinuria. We report a rare case of MCD developing secondary to iliac vein stenosis in a renal transplant recipient with SLE. Additionally we suggest that, in the event of biopsy-proven MCD presenting as an atypical nephrotic syndrome, alternative or secondary, potentially reversible, causes should be considered and explored. |
| format | Article |
| id | doaj-art-c4329f4f7a0d4106b6ef3dd25fa5bd7a |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-c4329f4f7a0d4106b6ef3dd25fa5bd7a2025-02-03T01:03:51ZengWileyCase Reports in Nephrology2090-66412090-665X2015-01-01201510.1155/2015/987212987212Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus ErythematosusElena Gkrouzman0Kyriakos A. Kirou1Surya V. Seshan2James M. Chevalier3University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1235, USADivision of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USANew York-Presbyterian Hospital, 525 East 68th Street, Starr Pavilion 1009, New York, NY 10021, USARogosin Kidney Center, 505 East 70th Street, New York, NY 10021, USASecondary causes of minimal change disease (MCD) account for a minority of cases compared to its primary or idiopathic form and provide ground for consideration of common mechanisms of pathogenesis. In this paper we report a case of a 27-year-old Latina woman, a renal transplant recipient with systemic lupus erythematosus (SLE), who developed nephrotic range proteinuria 6 months after transplantation. The patient had recurrent acute renal failure and multiple biopsies were consistent with MCD. However, she lacked any other features of the typical nephrotic syndrome. An angiogram revealed a right external iliac vein stenosis in the region of renal vein anastomosis, which when restored resulted in normalization of creatinine and relief from proteinuria. We report a rare case of MCD developing secondary to iliac vein stenosis in a renal transplant recipient with SLE. Additionally we suggest that, in the event of biopsy-proven MCD presenting as an atypical nephrotic syndrome, alternative or secondary, potentially reversible, causes should be considered and explored.http://dx.doi.org/10.1155/2015/987212 |
| spellingShingle | Elena Gkrouzman Kyriakos A. Kirou Surya V. Seshan James M. Chevalier Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus Case Reports in Nephrology |
| title | Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus |
| title_full | Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus |
| title_fullStr | Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus |
| title_full_unstemmed | Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus |
| title_short | Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus |
| title_sort | minimal change disease as a secondary and reversible event of a renal transplant case with systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2015/987212 |
| work_keys_str_mv | AT elenagkrouzman minimalchangediseaseasasecondaryandreversibleeventofarenaltransplantcasewithsystemiclupuserythematosus AT kyriakosakirou minimalchangediseaseasasecondaryandreversibleeventofarenaltransplantcasewithsystemiclupuserythematosus AT suryavseshan minimalchangediseaseasasecondaryandreversibleeventofarenaltransplantcasewithsystemiclupuserythematosus AT jamesmchevalier minimalchangediseaseasasecondaryandreversibleeventofarenaltransplantcasewithsystemiclupuserythematosus |