Wegener Granulomatosis Revealed by Pleural Effusion
Pulmonary signs are common in Wegener's granulomatosis (WG). However, an initial presentation including pleural effusion has not been described. We describe a case of WG in which pleural effusion was the first clinical manifestation. A 45-year-old man with dorsal pain presented with pleural thi...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2009/164395 |
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| author | Anne-Claire Toffart François Arbib Sylvie Lantuejoul Jean-François Roux Vincent Bland Gilbert Ferretti Samia Diab |
| author_facet | Anne-Claire Toffart François Arbib Sylvie Lantuejoul Jean-François Roux Vincent Bland Gilbert Ferretti Samia Diab |
| author_sort | Anne-Claire Toffart |
| collection | DOAJ |
| description | Pulmonary signs are common in Wegener's granulomatosis (WG). However, an initial presentation including pleural effusion has not been described. We describe a case of WG in which pleural effusion was the first clinical manifestation. A 45-year-old man with dorsal pain presented with pleural thickening and effusion, and a visible nodule on a thoracic scan. A dense chronic inflammatory infiltrate was obtained by pleural biopsy and an open lung biopsy revealed necrotizing granulomatous vasculitis. Serologies were positive for antineutrophil cytoplasmic antibodies and antiproteinase 3 antibodies. A diagnosis of WG was conducted and the patient was started on cyclophosphamide and methylprednisolone as an initial treatment, with a favorable evolution. Although pleural effusion is rarely described in WG, this pathology must be considered in the presence of this clinical manifestation. |
| format | Article |
| id | doaj-art-c42f54a62a9d4a6da7dc55ba86fc25f2 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-c42f54a62a9d4a6da7dc55ba86fc25f22025-02-03T01:00:35ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/164395164395Wegener Granulomatosis Revealed by Pleural EffusionAnne-Claire Toffart0François Arbib1Sylvie Lantuejoul2Jean-François Roux3Vincent Bland4Gilbert Ferretti5Samia Diab6Clinique de Pneumologie, Pôle Médecine Aiguë Communautaire, Centre Hospitalier Universitaire Albert Michallon, 38043 Grenoble cedex 09, FranceClinique de Pneumologie, Pôle Médecine Aiguë Communautaire, Centre Hospitalier Universitaire Albert Michallon, 38043 Grenoble cedex 09, FranceDépartement de Pathologie, Centre Hospitalier Universitaire Albert Michallon, 38000 Grenoble, FranceChirurgie Générale et Thoracique, Clinique des Cèdres, 38130 Echirolles, FranceCabinet Médical Anatomie Cytologie Pathologiques Ciapa Bland Muller, 38000 Grenoble, FranceINSERM U 823, Université Joseph Fourier, 38000 Grenoble, FranceClinique de Pneumologie, Pôle Médecine Aiguë Communautaire, Centre Hospitalier Universitaire Albert Michallon, 38043 Grenoble cedex 09, FrancePulmonary signs are common in Wegener's granulomatosis (WG). However, an initial presentation including pleural effusion has not been described. We describe a case of WG in which pleural effusion was the first clinical manifestation. A 45-year-old man with dorsal pain presented with pleural thickening and effusion, and a visible nodule on a thoracic scan. A dense chronic inflammatory infiltrate was obtained by pleural biopsy and an open lung biopsy revealed necrotizing granulomatous vasculitis. Serologies were positive for antineutrophil cytoplasmic antibodies and antiproteinase 3 antibodies. A diagnosis of WG was conducted and the patient was started on cyclophosphamide and methylprednisolone as an initial treatment, with a favorable evolution. Although pleural effusion is rarely described in WG, this pathology must be considered in the presence of this clinical manifestation.http://dx.doi.org/10.1155/2009/164395 |
| spellingShingle | Anne-Claire Toffart François Arbib Sylvie Lantuejoul Jean-François Roux Vincent Bland Gilbert Ferretti Samia Diab Wegener Granulomatosis Revealed by Pleural Effusion Case Reports in Medicine |
| title | Wegener Granulomatosis Revealed by Pleural Effusion |
| title_full | Wegener Granulomatosis Revealed by Pleural Effusion |
| title_fullStr | Wegener Granulomatosis Revealed by Pleural Effusion |
| title_full_unstemmed | Wegener Granulomatosis Revealed by Pleural Effusion |
| title_short | Wegener Granulomatosis Revealed by Pleural Effusion |
| title_sort | wegener granulomatosis revealed by pleural effusion |
| url | http://dx.doi.org/10.1155/2009/164395 |
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