Participation of the adrenal gland in the anti-inflammatory effect of polyunsaturated diets
The effect of an n-3 (fish) and n-6 (soybean) fatty acid-rich diet on carrageenin paw oedema in rats, and the participation of adrenal gland, corticosterone and α2-macroglobulin (α2-M) in this process were studied. A significant inhibition of carrageenin oedema was observed not only in rats fed a di...
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| Format: | Article |
| Language: | English |
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Wiley
1995-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935195000585 |
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| author | V. L. F. Silveira E. A. Limãos D. W. Nunes |
| author_facet | V. L. F. Silveira E. A. Limãos D. W. Nunes |
| author_sort | V. L. F. Silveira |
| collection | DOAJ |
| description | The effect of an n-3 (fish) and n-6 (soybean) fatty acid-rich diet on carrageenin paw oedema in rats, and the participation of adrenal gland, corticosterone and α2-macroglobulin (α2-M) in this process were studied. A significant inhibition of carrageenin oedema was observed not only in rats fed a diet rich in fish oil but also in the soybean group. α2-M was not detectable before carrageenin injection, suggesting that this putative antiinflammatory factor does not participate in the observed anti-inflammatory effect. Corticosterone levels were higher in fat-fed than in control rats, before carrageenin stimulus and adrenalectomy abolished the anti-inflammatory response in fat-fed animals, showing the important role of the adrenocortical hormones in this process. |
| format | Article |
| id | doaj-art-c42a5e6b01a14eac88cb9575b5493339 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c42a5e6b01a14eac88cb9575b54933392025-08-20T03:23:11ZengWileyMediators of Inflammation0962-93511466-18611995-01-014535936310.1155/S0962935195000585Participation of the adrenal gland in the anti-inflammatory effect of polyunsaturated dietsV. L. F. Silveira0E. A. Limãos1D. W. Nunes2Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo SP, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo SP, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo SP, BrazilThe effect of an n-3 (fish) and n-6 (soybean) fatty acid-rich diet on carrageenin paw oedema in rats, and the participation of adrenal gland, corticosterone and α2-macroglobulin (α2-M) in this process were studied. A significant inhibition of carrageenin oedema was observed not only in rats fed a diet rich in fish oil but also in the soybean group. α2-M was not detectable before carrageenin injection, suggesting that this putative antiinflammatory factor does not participate in the observed anti-inflammatory effect. Corticosterone levels were higher in fat-fed than in control rats, before carrageenin stimulus and adrenalectomy abolished the anti-inflammatory response in fat-fed animals, showing the important role of the adrenocortical hormones in this process.http://dx.doi.org/10.1155/S0962935195000585 |
| spellingShingle | V. L. F. Silveira E. A. Limãos D. W. Nunes Participation of the adrenal gland in the anti-inflammatory effect of polyunsaturated diets Mediators of Inflammation |
| title | Participation of the adrenal gland in the anti-inflammatory effect of polyunsaturated diets |
| title_full | Participation of the adrenal gland in the anti-inflammatory effect of polyunsaturated diets |
| title_fullStr | Participation of the adrenal gland in the anti-inflammatory effect of polyunsaturated diets |
| title_full_unstemmed | Participation of the adrenal gland in the anti-inflammatory effect of polyunsaturated diets |
| title_short | Participation of the adrenal gland in the anti-inflammatory effect of polyunsaturated diets |
| title_sort | participation of the adrenal gland in the anti inflammatory effect of polyunsaturated diets |
| url | http://dx.doi.org/10.1155/S0962935195000585 |
| work_keys_str_mv | AT vlfsilveira participationoftheadrenalglandintheantiinflammatoryeffectofpolyunsaturateddiets AT ealimaos participationoftheadrenalglandintheantiinflammatoryeffectofpolyunsaturateddiets AT dwnunes participationoftheadrenalglandintheantiinflammatoryeffectofpolyunsaturateddiets |