Drug-induced lupus
Drug-induced lupus erythematosus (DILE) is an important differential to consider in a clinical setting of mild lupus. Numerous drugs ranging from the classically described procainamide and hydralazine to novel biological agents such as anti-tumor necrosis factors and immune checkpoint inhibitors are...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=10;epage=18;aulast=G |
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| _version_ | 1832542977619132416 |
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| author | Kavadichanda Chengappa G |
| author_facet | Kavadichanda Chengappa G |
| author_sort | Kavadichanda Chengappa G |
| collection | DOAJ |
| description | Drug-induced lupus erythematosus (DILE) is an important differential to consider in a clinical setting of mild lupus. Numerous drugs ranging from the classically described procainamide and hydralazine to novel biological agents such as anti-tumor necrosis factors and immune checkpoint inhibitors are implicated in causing DILE. Various pathophysiologic mechanisms such as decreased central tolerance, molecular cross-reactivity, and epigenetic modifications of immune cells are known to play a role in the precipitation of drug-induced autoimmunity. Early recognition and prompt withdrawal of the offending agent is often sufficient to treat these autoimmune manifestations. A thorough knowledge of DILE is essential to ensure better patient care and better understand the role of xenobiotics in precipitating autoimmunity. |
| format | Article |
| id | doaj-art-c427c6960ef744e0814608347649446c |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-c427c6960ef744e0814608347649446c2025-02-03T12:03:23ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012019-01-01145101810.4103/0973-3698.272154Drug-induced lupusKavadichanda Chengappa GDrug-induced lupus erythematosus (DILE) is an important differential to consider in a clinical setting of mild lupus. Numerous drugs ranging from the classically described procainamide and hydralazine to novel biological agents such as anti-tumor necrosis factors and immune checkpoint inhibitors are implicated in causing DILE. Various pathophysiologic mechanisms such as decreased central tolerance, molecular cross-reactivity, and epigenetic modifications of immune cells are known to play a role in the precipitation of drug-induced autoimmunity. Early recognition and prompt withdrawal of the offending agent is often sufficient to treat these autoimmune manifestations. A thorough knowledge of DILE is essential to ensure better patient care and better understand the role of xenobiotics in precipitating autoimmunity.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=10;epage=18;aulast=Gdrug rashdrug-inducedlupuspharmacogenomicssubacute cutaneous lupus erythematosusxenobiotics |
| spellingShingle | Kavadichanda Chengappa G Drug-induced lupus Indian Journal of Rheumatology drug rash drug-induced lupus pharmacogenomics subacute cutaneous lupus erythematosus xenobiotics |
| title | Drug-induced lupus |
| title_full | Drug-induced lupus |
| title_fullStr | Drug-induced lupus |
| title_full_unstemmed | Drug-induced lupus |
| title_short | Drug-induced lupus |
| title_sort | drug induced lupus |
| topic | drug rash drug-induced lupus pharmacogenomics subacute cutaneous lupus erythematosus xenobiotics |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=10;epage=18;aulast=G |
| work_keys_str_mv | AT kavadichandachengappag druginducedlupus |