Reliability of intracortical inhibiton measured using threshold tracking technique
Background. Paired-pulse transcranial magnetic stimulation allows assessing intracortical inhibition. However, a high variability of motor evoked potential (MEP) amplitude is a limitation of its use. Therefore, a new threshold tracking technique became of particular interest, which is based on the m...
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| Format: | Article |
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ABV-press
2024-01-01
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| Series: | Нервно-мышечные болезни |
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| Online Access: | https://nmb.abvpress.ru/jour/article/view/569 |
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| author | I. S. Bakulin A. Kh. Zabirova A. G. Poydasheva D. O. Sinitsyn D. Yu. Lagoda N. A. Suponeva M. A. Piradov |
| author_facet | I. S. Bakulin A. Kh. Zabirova A. G. Poydasheva D. O. Sinitsyn D. Yu. Lagoda N. A. Suponeva M. A. Piradov |
| author_sort | I. S. Bakulin |
| collection | DOAJ |
| description | Background. Paired-pulse transcranial magnetic stimulation allows assessing intracortical inhibition. However, a high variability of motor evoked potential (MEP) amplitude is a limitation of its use. Therefore, a new threshold tracking technique became of particular interest, which is based on the measurement not of the amplitude, but of the change of test stimulus intensity required to induce a MEP of a given amplitude.Aim. The assessment of absolute and relative reliability of short-interval intracortical inhibition (SICI) using threshold tracking technique in healthy volunteers.Materials and methods. All healthy volunteers included into the study (n = 12) underwent diagnostic paired-pulse transcranial magnetic stimulation in two consecutive days. The procedure included registration of passive motor threshold; the registration of 30 MEPs with supra-threshold intensity and determination of SICI using threshold tracking technique. At the first day the procedure was performed twice (T1, T2), at the second day – once (T3). Standard error of the measurement (SEM) and SEM% were calculated to assess absolute reliability, and intra-class correlation coefficient – for the assessment of relative reliability.Results. A good or excellent relative reliability were observed for SICI averaged at intervals 1.0–3.0 ms and 1.0–7.0 ms when assessed within a day or at different days. Relative reliability of SICI at separate interstimulus intervals varied in a wide range. SEM% was more than 10 % both for averaged SICI and SICI at all interstimulus intervals. Motor threshold had excellent reliability both assessed within a day and at different days, and low SEM values (5.6 % for Т1–Т2 and 4.39 % for Т1–Т3). High SEM and SEM% were observed for average MEP amplitude, it also had a moderate relative reliability when assessed within a day and a poor one – at different days.Conclusion. Calculation of averaged SICI can be recommended in further studies because of its high reliability values. |
| format | Article |
| id | doaj-art-c424e211dcc14ef7994fe8fa744533c3 |
| institution | Kabale University |
| issn | 2222-8721 2413-0443 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Нервно-мышечные болезни |
| spelling | doaj-art-c424e211dcc14ef7994fe8fa744533c32025-08-20T03:37:51ZrusABV-pressНервно-мышечные болезни2222-87212413-04432024-01-0113410.17650/2222-8721-2023-13-4-10-19360Reliability of intracortical inhibiton measured using threshold tracking techniqueI. S. Bakulin0A. Kh. Zabirova1A. G. Poydasheva2D. O. Sinitsyn3D. Yu. Lagoda4N. A. Suponeva5M. A. Piradov6Research Center of NeurologyResearch Center of NeurologyResearch Center of NeurologyResearch Center of NeurologyResearch Center of NeurologyResearch Center of NeurologyResearch Center of NeurologyBackground. Paired-pulse transcranial magnetic stimulation allows assessing intracortical inhibition. However, a high variability of motor evoked potential (MEP) amplitude is a limitation of its use. Therefore, a new threshold tracking technique became of particular interest, which is based on the measurement not of the amplitude, but of the change of test stimulus intensity required to induce a MEP of a given amplitude.Aim. The assessment of absolute and relative reliability of short-interval intracortical inhibition (SICI) using threshold tracking technique in healthy volunteers.Materials and methods. All healthy volunteers included into the study (n = 12) underwent diagnostic paired-pulse transcranial magnetic stimulation in two consecutive days. The procedure included registration of passive motor threshold; the registration of 30 MEPs with supra-threshold intensity and determination of SICI using threshold tracking technique. At the first day the procedure was performed twice (T1, T2), at the second day – once (T3). Standard error of the measurement (SEM) and SEM% were calculated to assess absolute reliability, and intra-class correlation coefficient – for the assessment of relative reliability.Results. A good or excellent relative reliability were observed for SICI averaged at intervals 1.0–3.0 ms and 1.0–7.0 ms when assessed within a day or at different days. Relative reliability of SICI at separate interstimulus intervals varied in a wide range. SEM% was more than 10 % both for averaged SICI and SICI at all interstimulus intervals. Motor threshold had excellent reliability both assessed within a day and at different days, and low SEM values (5.6 % for Т1–Т2 and 4.39 % for Т1–Т3). High SEM and SEM% were observed for average MEP amplitude, it also had a moderate relative reliability when assessed within a day and a poor one – at different days.Conclusion. Calculation of averaged SICI can be recommended in further studies because of its high reliability values.https://nmb.abvpress.ru/jour/article/view/569transcranial magnetic stimulationpaired-pulse stimulationintracortical inhibitionthreshold trackingreliability |
| spellingShingle | I. S. Bakulin A. Kh. Zabirova A. G. Poydasheva D. O. Sinitsyn D. Yu. Lagoda N. A. Suponeva M. A. Piradov Reliability of intracortical inhibiton measured using threshold tracking technique Нервно-мышечные болезни transcranial magnetic stimulation paired-pulse stimulation intracortical inhibition threshold tracking reliability |
| title | Reliability of intracortical inhibiton measured using threshold tracking technique |
| title_full | Reliability of intracortical inhibiton measured using threshold tracking technique |
| title_fullStr | Reliability of intracortical inhibiton measured using threshold tracking technique |
| title_full_unstemmed | Reliability of intracortical inhibiton measured using threshold tracking technique |
| title_short | Reliability of intracortical inhibiton measured using threshold tracking technique |
| title_sort | reliability of intracortical inhibiton measured using threshold tracking technique |
| topic | transcranial magnetic stimulation paired-pulse stimulation intracortical inhibition threshold tracking reliability |
| url | https://nmb.abvpress.ru/jour/article/view/569 |
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