Novel Nanoparticle Biomaterial of Alginate/Chitosan Loading Simultaneously Lovastatin and Ginsenoside RB1: Characteristics, Morphology, and Drug Release Study
Recently, plenty of interesting studies on improvement of bioavailability for poorly soluble drugs were implemented with different approaches such as using of combined biopolymers as a delivery system that allowed to enhancing drug solubility and bioavailability. In this work, alginate and chitosan...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2021/5214510 |
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| author | Quan Vo-An Thuy Chinh Nguyen Quang Tung Nguyen Quoc Trung Vu Cong Doanh Truong Thi Len Nguyen Thi Ngoc Lien Ly Long Giang Bach Hoang Thai |
| author_facet | Quan Vo-An Thuy Chinh Nguyen Quang Tung Nguyen Quoc Trung Vu Cong Doanh Truong Thi Len Nguyen Thi Ngoc Lien Ly Long Giang Bach Hoang Thai |
| author_sort | Quan Vo-An |
| collection | DOAJ |
| description | Recently, plenty of interesting studies on improvement of bioavailability for poorly soluble drugs were implemented with different approaches such as using of combined biopolymers as a delivery system that allowed to enhancing drug solubility and bioavailability. In this work, alginate and chitosan were blended together in the form of polymeric particles, loaded with both lovastatin and ginsenoside Rb1 to producing the four-component nanoparticles by ionic gelation method. CaCl2 and sodium tripolyphosphate were used as gelation agent and cross-linking agent, respectively. The characteristics of obtained nanoparticles were studied by means of infrared spectra (IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and dynamic light scattering (DLS). In combination, ginsenoside Rb1 and lovastatin both interacted with each other to improve the drug release ability of the polymer particles. The change of initial content of drugs in the nanoparticles has a negligible effect on the functional groups in the structure of the nanoparticles but has a significant impact on drug release process of both lovastatin and ginsenoside Rb1 from the nanoparticles in selective simulated body fluids. In addition, the synergistic interaction of lovastatin and ginsenoside Rb1 could be also observed through the modification of relative crystal degree and drug release efficiency. |
| format | Article |
| id | doaj-art-c422b6345ac04599b33f147abe091c0d |
| institution | OA Journals |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-c422b6345ac04599b33f147abe091c0d2025-08-20T02:18:55ZengWileyInternational Journal of Polymer Science1687-94221687-94302021-01-01202110.1155/2021/52145105214510Novel Nanoparticle Biomaterial of Alginate/Chitosan Loading Simultaneously Lovastatin and Ginsenoside RB1: Characteristics, Morphology, and Drug Release StudyQuan Vo-An0Thuy Chinh Nguyen1Quang Tung Nguyen2Quoc Trung Vu3Cong Doanh Truong4Thi Len Nguyen5Thi Ngoc Lien Ly6Long Giang Bach7Hoang Thai8Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 100000, VietnamInstitute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 100000, VietnamHanoi University of Industry, No. 298, Cau Dien Street, Bac Tu Liem District, Ha Noi 100000, VietnamFaculty of Chemistry, Hanoi National University of Education, No. 136 Xuan Thuy Road, Cau Giay, Ha Noi 100000, VietnamHanoi University of Industry, No. 298, Cau Dien Street, Bac Tu Liem District, Ha Noi 100000, VietnamHanoi University of Industry, No. 298, Cau Dien Street, Bac Tu Liem District, Ha Noi 100000, VietnamHanoi University of Industry, No. 298, Cau Dien Street, Bac Tu Liem District, Ha Noi 100000, VietnamNTT Institute of High Technology, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, District 4, Ho Chi Minh City 700000, VietnamInstitute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 100000, VietnamRecently, plenty of interesting studies on improvement of bioavailability for poorly soluble drugs were implemented with different approaches such as using of combined biopolymers as a delivery system that allowed to enhancing drug solubility and bioavailability. In this work, alginate and chitosan were blended together in the form of polymeric particles, loaded with both lovastatin and ginsenoside Rb1 to producing the four-component nanoparticles by ionic gelation method. CaCl2 and sodium tripolyphosphate were used as gelation agent and cross-linking agent, respectively. The characteristics of obtained nanoparticles were studied by means of infrared spectra (IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and dynamic light scattering (DLS). In combination, ginsenoside Rb1 and lovastatin both interacted with each other to improve the drug release ability of the polymer particles. The change of initial content of drugs in the nanoparticles has a negligible effect on the functional groups in the structure of the nanoparticles but has a significant impact on drug release process of both lovastatin and ginsenoside Rb1 from the nanoparticles in selective simulated body fluids. In addition, the synergistic interaction of lovastatin and ginsenoside Rb1 could be also observed through the modification of relative crystal degree and drug release efficiency.http://dx.doi.org/10.1155/2021/5214510 |
| spellingShingle | Quan Vo-An Thuy Chinh Nguyen Quang Tung Nguyen Quoc Trung Vu Cong Doanh Truong Thi Len Nguyen Thi Ngoc Lien Ly Long Giang Bach Hoang Thai Novel Nanoparticle Biomaterial of Alginate/Chitosan Loading Simultaneously Lovastatin and Ginsenoside RB1: Characteristics, Morphology, and Drug Release Study International Journal of Polymer Science |
| title | Novel Nanoparticle Biomaterial of Alginate/Chitosan Loading Simultaneously Lovastatin and Ginsenoside RB1: Characteristics, Morphology, and Drug Release Study |
| title_full | Novel Nanoparticle Biomaterial of Alginate/Chitosan Loading Simultaneously Lovastatin and Ginsenoside RB1: Characteristics, Morphology, and Drug Release Study |
| title_fullStr | Novel Nanoparticle Biomaterial of Alginate/Chitosan Loading Simultaneously Lovastatin and Ginsenoside RB1: Characteristics, Morphology, and Drug Release Study |
| title_full_unstemmed | Novel Nanoparticle Biomaterial of Alginate/Chitosan Loading Simultaneously Lovastatin and Ginsenoside RB1: Characteristics, Morphology, and Drug Release Study |
| title_short | Novel Nanoparticle Biomaterial of Alginate/Chitosan Loading Simultaneously Lovastatin and Ginsenoside RB1: Characteristics, Morphology, and Drug Release Study |
| title_sort | novel nanoparticle biomaterial of alginate chitosan loading simultaneously lovastatin and ginsenoside rb1 characteristics morphology and drug release study |
| url | http://dx.doi.org/10.1155/2021/5214510 |
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