Health economics evaluation of diagnostic strategies for gastro-oesophageal reflux disease with reflux symptoms in China: a modelling study
Objectives American College of Gastroenterology (ACG) and Chinese expert consensus recommended different algorithmic approaches for the diagnosis of gastro-oesophageal reflux disease (GERD) are not yet defined. We compared the two recommended diagnostic processes using a Chinese population-based hea...
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BMJ Publishing Group
2025-05-01
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| author | Yang Chen Feng Xie Hongda Chen Dong Wu Xiaoqing Li Xiaxiao Yan Meiduo Ouzhu Ziqi Guo Chengzhen Lyu Daiyu Yang |
| author_facet | Yang Chen Feng Xie Hongda Chen Dong Wu Xiaoqing Li Xiaxiao Yan Meiduo Ouzhu Ziqi Guo Chengzhen Lyu Daiyu Yang |
| author_sort | Yang Chen |
| collection | DOAJ |
| description | Objectives American College of Gastroenterology (ACG) and Chinese expert consensus recommended different algorithmic approaches for the diagnosis of gastro-oesophageal reflux disease (GERD) are not yet defined. We compared the two recommended diagnostic processes using a Chinese population-based health economics analysis.Methods Our analysis considered a hypothetical cohort of patients with typical reflux symptoms. We constructed a decision tree model to compare the two recommended diagnostic processes described in ACG clinical guidelines (stratified endoscopy strategy) and Chinese expert consensus (endoscopy-first strategy). The first strategy begins with hazard stratification based on alarm symptoms. Patients with alarm symptoms directly undergo endoscopic examination, while patients without alarm symptoms receive proton pump inhibitors as diagnostic treatment. In the second strategy, all patients with reflux symptoms complete an endoscopic examination. Sensitivity analysis was performed to evaluate a range of cost and probability estimates on costs and health outcomes over a 1-year time horizon from the healthcare system perspective.Results The total expected costs were US$122.51 for the stratified endoscopy strategy and US$150.12 for the endoscopy-first strategy. The incremental cost-effectiveness ratio (ICER) comparing the endoscopy-first strategy with the stratified endoscopy strategy was US$440.39 per additional correct case of GERD. The rates of detecting upper gastrointestinal carcinoma of the two strategies were 0.0088 and 0.0120, and the ICER was US$8561.34.Conclusions The use of endoscopy for all patients with reflux symptoms was more effective but with an increased cost compared with the strategy recommended in international guidelines. |
| format | Article |
| id | doaj-art-c4222cdfe2fc40b7b63eb2805b2ee4d3 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-05-01 |
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| series | BMJ Open |
| spelling | doaj-art-c4222cdfe2fc40b7b63eb2805b2ee4d32025-08-20T02:31:02ZengBMJ Publishing GroupBMJ Open2044-60552025-05-0115510.1136/bmjopen-2024-093108Health economics evaluation of diagnostic strategies for gastro-oesophageal reflux disease with reflux symptoms in China: a modelling studyYang Chen0Feng Xie1Hongda Chen2Dong Wu3Xiaoqing Li4Xiaxiao Yan5Meiduo Ouzhu6Ziqi Guo7Chengzhen Lyu8Daiyu Yang9Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, CanadaCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Gastroenterology, Tibet Autonomous Region People’s Hospital, Lhasa, ChinaPeking Union Medical College, Beijing, ChinaDepartment of Gastroenterology, Peking Union Medical College Hospital, Beijing, ChinaPeking Union Medical College, Beijing, ChinaObjectives American College of Gastroenterology (ACG) and Chinese expert consensus recommended different algorithmic approaches for the diagnosis of gastro-oesophageal reflux disease (GERD) are not yet defined. We compared the two recommended diagnostic processes using a Chinese population-based health economics analysis.Methods Our analysis considered a hypothetical cohort of patients with typical reflux symptoms. We constructed a decision tree model to compare the two recommended diagnostic processes described in ACG clinical guidelines (stratified endoscopy strategy) and Chinese expert consensus (endoscopy-first strategy). The first strategy begins with hazard stratification based on alarm symptoms. Patients with alarm symptoms directly undergo endoscopic examination, while patients without alarm symptoms receive proton pump inhibitors as diagnostic treatment. In the second strategy, all patients with reflux symptoms complete an endoscopic examination. Sensitivity analysis was performed to evaluate a range of cost and probability estimates on costs and health outcomes over a 1-year time horizon from the healthcare system perspective.Results The total expected costs were US$122.51 for the stratified endoscopy strategy and US$150.12 for the endoscopy-first strategy. The incremental cost-effectiveness ratio (ICER) comparing the endoscopy-first strategy with the stratified endoscopy strategy was US$440.39 per additional correct case of GERD. The rates of detecting upper gastrointestinal carcinoma of the two strategies were 0.0088 and 0.0120, and the ICER was US$8561.34.Conclusions The use of endoscopy for all patients with reflux symptoms was more effective but with an increased cost compared with the strategy recommended in international guidelines.https://bmjopen.bmj.com/content/15/5/e093108.full |
| spellingShingle | Yang Chen Feng Xie Hongda Chen Dong Wu Xiaoqing Li Xiaxiao Yan Meiduo Ouzhu Ziqi Guo Chengzhen Lyu Daiyu Yang Health economics evaluation of diagnostic strategies for gastro-oesophageal reflux disease with reflux symptoms in China: a modelling study BMJ Open |
| title | Health economics evaluation of diagnostic strategies for gastro-oesophageal reflux disease with reflux symptoms in China: a modelling study |
| title_full | Health economics evaluation of diagnostic strategies for gastro-oesophageal reflux disease with reflux symptoms in China: a modelling study |
| title_fullStr | Health economics evaluation of diagnostic strategies for gastro-oesophageal reflux disease with reflux symptoms in China: a modelling study |
| title_full_unstemmed | Health economics evaluation of diagnostic strategies for gastro-oesophageal reflux disease with reflux symptoms in China: a modelling study |
| title_short | Health economics evaluation of diagnostic strategies for gastro-oesophageal reflux disease with reflux symptoms in China: a modelling study |
| title_sort | health economics evaluation of diagnostic strategies for gastro oesophageal reflux disease with reflux symptoms in china a modelling study |
| url | https://bmjopen.bmj.com/content/15/5/e093108.full |
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