Prolonged Hypercalcemia Following Resection of Dysgerminoma: A Case Report
Background. Hypercalcemia is a rare but potentially dangerous complication of pediatric cancer. Of the dysgerminoma cases reported to date, associated hypercalcemia is corrected within 2–7 days of tumor resection. Case. A 13-year-old female with an ovarian dysgerminoma was found to be hypercalcemi...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2009/956935 |
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| author | Abigail Wald Sumana Narasimhan Lucybeth Nieves-Arriba Steven Waggoner |
| author_facet | Abigail Wald Sumana Narasimhan Lucybeth Nieves-Arriba Steven Waggoner |
| author_sort | Abigail Wald |
| collection | DOAJ |
| description | Background. Hypercalcemia is a rare but potentially dangerous complication of pediatric cancer. Of the dysgerminoma cases reported to date, associated hypercalcemia is corrected within 2–7 days of tumor resection.
Case. A 13-year-old female with an ovarian dysgerminoma was found to be hypercalcemic on presentation. Following dysgerminoma resection, moderate hypercaclemia persisted for 7 days and calcium remained mildly elevated for an additional 7 days. PTHrP was undetectable. Immunolocalization studies indicated that 1𝛼-hydroxylase was expressed in dysgerminoma tissue but 1,25(OH)2D3 was not elevated. Conclusion. Persistently elevated calcium levels following tumor resection suggests that this case involves a previously undescribed mechanism. Elucidation of this mechanism may offer new insights into tumor biology and opportunities for therapeutic correction of hypercalcemia in this patient population. |
| format | Article |
| id | doaj-art-c42077794cfa4e30bbb38a2bc6cb011d |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-c42077794cfa4e30bbb38a2bc6cb011d2025-02-03T06:01:19ZengWileyObstetrics and Gynecology International1687-95891687-95972009-01-01200910.1155/2009/956935956935Prolonged Hypercalcemia Following Resection of Dysgerminoma: A Case ReportAbigail Wald0Sumana Narasimhan1Lucybeth Nieves-Arriba2Steven Waggoner3Department of Pediatric Endocrinology, Rainbow Babies & Children's Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USADepartment of Pediatric Endocrinology, Rainbow Babies & Children's Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USADepartment of Gynecological Oncology, University Hospitals, 11100 Euclid Avenue, Cleveland, OH 44106, USADepartment of Gynecological Oncology, University Hospitals, 11100 Euclid Avenue, Cleveland, OH 44106, USABackground. Hypercalcemia is a rare but potentially dangerous complication of pediatric cancer. Of the dysgerminoma cases reported to date, associated hypercalcemia is corrected within 2–7 days of tumor resection. Case. A 13-year-old female with an ovarian dysgerminoma was found to be hypercalcemic on presentation. Following dysgerminoma resection, moderate hypercaclemia persisted for 7 days and calcium remained mildly elevated for an additional 7 days. PTHrP was undetectable. Immunolocalization studies indicated that 1𝛼-hydroxylase was expressed in dysgerminoma tissue but 1,25(OH)2D3 was not elevated. Conclusion. Persistently elevated calcium levels following tumor resection suggests that this case involves a previously undescribed mechanism. Elucidation of this mechanism may offer new insights into tumor biology and opportunities for therapeutic correction of hypercalcemia in this patient population.http://dx.doi.org/10.1155/2009/956935 |
| spellingShingle | Abigail Wald Sumana Narasimhan Lucybeth Nieves-Arriba Steven Waggoner Prolonged Hypercalcemia Following Resection of Dysgerminoma: A Case Report Obstetrics and Gynecology International |
| title | Prolonged Hypercalcemia Following Resection of Dysgerminoma: A Case Report |
| title_full | Prolonged Hypercalcemia Following Resection of Dysgerminoma: A Case Report |
| title_fullStr | Prolonged Hypercalcemia Following Resection of Dysgerminoma: A Case Report |
| title_full_unstemmed | Prolonged Hypercalcemia Following Resection of Dysgerminoma: A Case Report |
| title_short | Prolonged Hypercalcemia Following Resection of Dysgerminoma: A Case Report |
| title_sort | prolonged hypercalcemia following resection of dysgerminoma a case report |
| url | http://dx.doi.org/10.1155/2009/956935 |
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