Prediction of Outcome from Community-Acquired Severe Sepsis and Septic Shock in Tertiary-Care University Hospital in a Developing Country
Our aim was to determine the risk factors on mortality in adult patients with community-acquired severe sepsis and septic shock. The main outcome measure was hospital mortality. This prospective single centre study was conducted from January 1, 2008 to December 31, 2010, and included 184 patients,...
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Wiley
2012-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/182324 |
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| author | Krsto Grozdanovski Zvonko Milenkovic Ilir Demiri Katerina Spasovska |
| author_facet | Krsto Grozdanovski Zvonko Milenkovic Ilir Demiri Katerina Spasovska |
| author_sort | Krsto Grozdanovski |
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| description | Our aim was to determine the risk factors on mortality in adult patients with community-acquired severe sepsis and septic shock. The main outcome measure was hospital mortality. This prospective single centre study was conducted from January 1, 2008 to December 31, 2010, and included 184 patients, of whom 135 (73.4%) were with severe sepsis and 49 (26.6%) had septic shock. Overall, ninety-five (51.6%) patients have died, 60 (44.4%) in severe sepsis and 35 (71.4%) patients with septic shock. The lung was the most common site of infection 121 (65.8%), and chronic heart failure was the most frequent comorbidity 65 (35.3%). Logistic multivariate analysis identified three independent risk factors for mortality in patients with severe sepsis: positive blood culture (odds ratio, 2.39; 95% confidence interval, 1.13–5.06; ), three or more organ dysfunctions (odds ratio, 3.93; 95% confidence interval, 1.62–9.53; ), and Simplified Acute Physiology Score (SAPS) II (odds ratio, 1.02; 95% confidence interval, 1.00–1.04; ). In addition to SAPS II, positive blood culture, and three or more organ dysfunctions are important independent risk factors for mortality in patients with severe sepsis and septic shock. |
| format | Article |
| id | doaj-art-c41d787b567849f39ba44fef51ca1e76 |
| institution | DOAJ |
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| publishDate | 2012-01-01 |
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| series | Critical Care Research and Practice |
| spelling | doaj-art-c41d787b567849f39ba44fef51ca1e762025-08-20T03:23:11ZengWileyCritical Care Research and Practice2090-13052090-13132012-01-01201210.1155/2012/182324182324Prediction of Outcome from Community-Acquired Severe Sepsis and Septic Shock in Tertiary-Care University Hospital in a Developing CountryKrsto Grozdanovski0Zvonko Milenkovic1Ilir Demiri2Katerina Spasovska3Department of Intensive Care, University Clinic for Infectious Diseases, Vodnjanska 17, 1000 Skopje, MacedoniaDepartment of Intensive Care, University Clinic for Infectious Diseases, Vodnjanska 17, 1000 Skopje, MacedoniaDepartment of Intensive Care, University Clinic for Infectious Diseases, Vodnjanska 17, 1000 Skopje, MacedoniaDepartment of Intensive Care, University Clinic for Infectious Diseases, Vodnjanska 17, 1000 Skopje, MacedoniaOur aim was to determine the risk factors on mortality in adult patients with community-acquired severe sepsis and septic shock. The main outcome measure was hospital mortality. This prospective single centre study was conducted from January 1, 2008 to December 31, 2010, and included 184 patients, of whom 135 (73.4%) were with severe sepsis and 49 (26.6%) had septic shock. Overall, ninety-five (51.6%) patients have died, 60 (44.4%) in severe sepsis and 35 (71.4%) patients with septic shock. The lung was the most common site of infection 121 (65.8%), and chronic heart failure was the most frequent comorbidity 65 (35.3%). Logistic multivariate analysis identified three independent risk factors for mortality in patients with severe sepsis: positive blood culture (odds ratio, 2.39; 95% confidence interval, 1.13–5.06; ), three or more organ dysfunctions (odds ratio, 3.93; 95% confidence interval, 1.62–9.53; ), and Simplified Acute Physiology Score (SAPS) II (odds ratio, 1.02; 95% confidence interval, 1.00–1.04; ). In addition to SAPS II, positive blood culture, and three or more organ dysfunctions are important independent risk factors for mortality in patients with severe sepsis and septic shock.http://dx.doi.org/10.1155/2012/182324 |
| spellingShingle | Krsto Grozdanovski Zvonko Milenkovic Ilir Demiri Katerina Spasovska Prediction of Outcome from Community-Acquired Severe Sepsis and Septic Shock in Tertiary-Care University Hospital in a Developing Country Critical Care Research and Practice |
| title | Prediction of Outcome from Community-Acquired Severe Sepsis and Septic Shock in Tertiary-Care University Hospital in a Developing Country |
| title_full | Prediction of Outcome from Community-Acquired Severe Sepsis and Septic Shock in Tertiary-Care University Hospital in a Developing Country |
| title_fullStr | Prediction of Outcome from Community-Acquired Severe Sepsis and Septic Shock in Tertiary-Care University Hospital in a Developing Country |
| title_full_unstemmed | Prediction of Outcome from Community-Acquired Severe Sepsis and Septic Shock in Tertiary-Care University Hospital in a Developing Country |
| title_short | Prediction of Outcome from Community-Acquired Severe Sepsis and Septic Shock in Tertiary-Care University Hospital in a Developing Country |
| title_sort | prediction of outcome from community acquired severe sepsis and septic shock in tertiary care university hospital in a developing country |
| url | http://dx.doi.org/10.1155/2012/182324 |
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