Resveratrol-Loaded Dissolving Microneedles: Fabrication and <i>in vitro</i> Evaluation
Resveratrol (Res), an active ingredient derived from a multitude of plants, exhibits multiple pharmacological activities. However, its poor water solubility and low bioavailability present significant challenges to its clinical application. Our study aimed to improve the transdermal absorption of Re...
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| Format: | Article |
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Georg Thieme Verlag KG
2024-12-01
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| Series: | Pharmaceutical Fronts |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1791832 |
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| author | Banghuai Xing Qian Luo Tiantian Gan Yi Jin Jianfang Feng Meng Cheng Liangxing Tu |
| author_facet | Banghuai Xing Qian Luo Tiantian Gan Yi Jin Jianfang Feng Meng Cheng Liangxing Tu |
| author_sort | Banghuai Xing |
| collection | DOAJ |
| description | Resveratrol (Res), an active ingredient derived from a multitude of plants, exhibits multiple pharmacological activities. However, its poor water solubility and low bioavailability present significant challenges to its clinical application. Our study aimed to improve the transdermal absorption of Res using dissolving microneedle (MN) technology, which could effectively overcome the stratum corneum barrier. Res-loaded dissolving microneedles (Res-MNs) were fabricated using polyvinyl pyrrolidone K90 (PVP K90) as the matrix material, and a two-step casting procedure was employed. The process was optimized using the Box–Behnken experimental design approach. The characteristics of Res-MNs in vitro, including morphology, solubility, safety evaluation, and skin permeation, were studied. The results showed that the optimum preparation conditions of Res-MNs were a centrifugation time of 10 minutes, a solvent concentration of 25%, and a prescription ratio (Res: matrix) of 0.375. The skin permeability of the Res-MNs was enhanced compared with Res suspension and Res gel. The cumulative release of Res-MNs in vitro was 75%, which was approximately 5 and 3 times that of the Res suspension group and Res gel group. These results suggest that dissolving MNs may represent a potential approach for enhancing the transdermal delivery of poorly absorbed drugs such as Res. |
| format | Article |
| id | doaj-art-c413d45fa5ff4aefb1ac53a1a8306825 |
| institution | OA Journals |
| issn | 2628-5088 2628-5096 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Pharmaceutical Fronts |
| spelling | doaj-art-c413d45fa5ff4aefb1ac53a1a83068252025-08-20T02:32:11ZengGeorg Thieme Verlag KGPharmaceutical Fronts2628-50882628-50962024-12-010604e439e44810.1055/s-0044-1791832Resveratrol-Loaded Dissolving Microneedles: Fabrication and <i>in vitro</i> EvaluationBanghuai Xing0Qian Luo1Tiantian Gan2Yi Jin3Jianfang Feng4Meng Cheng5Liangxing Tu6Division of Innovative Pharmaceutical Sciences, National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaDivision of Innovative Pharmaceutical Sciences, National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaDivision of Innovative Pharmaceutical Sciences, National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaDivision of Innovative Pharmaceutical Sciences, National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaDivision of Innovative Pharmaceutical Sciences, National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaGCP Center, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, People's Republic of ChinaDivision of Innovative Pharmaceutical Sciences, National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaResveratrol (Res), an active ingredient derived from a multitude of plants, exhibits multiple pharmacological activities. However, its poor water solubility and low bioavailability present significant challenges to its clinical application. Our study aimed to improve the transdermal absorption of Res using dissolving microneedle (MN) technology, which could effectively overcome the stratum corneum barrier. Res-loaded dissolving microneedles (Res-MNs) were fabricated using polyvinyl pyrrolidone K90 (PVP K90) as the matrix material, and a two-step casting procedure was employed. The process was optimized using the Box–Behnken experimental design approach. The characteristics of Res-MNs in vitro, including morphology, solubility, safety evaluation, and skin permeation, were studied. The results showed that the optimum preparation conditions of Res-MNs were a centrifugation time of 10 minutes, a solvent concentration of 25%, and a prescription ratio (Res: matrix) of 0.375. The skin permeability of the Res-MNs was enhanced compared with Res suspension and Res gel. The cumulative release of Res-MNs in vitro was 75%, which was approximately 5 and 3 times that of the Res suspension group and Res gel group. These results suggest that dissolving MNs may represent a potential approach for enhancing the transdermal delivery of poorly absorbed drugs such as Res.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1791832microneedletransdermalresveratrolabsorptionpolyvinylpyrrolidone K90 |
| spellingShingle | Banghuai Xing Qian Luo Tiantian Gan Yi Jin Jianfang Feng Meng Cheng Liangxing Tu Resveratrol-Loaded Dissolving Microneedles: Fabrication and <i>in vitro</i> Evaluation Pharmaceutical Fronts microneedle transdermal resveratrol absorption polyvinylpyrrolidone K90 |
| title | Resveratrol-Loaded Dissolving Microneedles: Fabrication and <i>in vitro</i> Evaluation |
| title_full | Resveratrol-Loaded Dissolving Microneedles: Fabrication and <i>in vitro</i> Evaluation |
| title_fullStr | Resveratrol-Loaded Dissolving Microneedles: Fabrication and <i>in vitro</i> Evaluation |
| title_full_unstemmed | Resveratrol-Loaded Dissolving Microneedles: Fabrication and <i>in vitro</i> Evaluation |
| title_short | Resveratrol-Loaded Dissolving Microneedles: Fabrication and <i>in vitro</i> Evaluation |
| title_sort | resveratrol loaded dissolving microneedles fabrication and i in vitro i evaluation |
| topic | microneedle transdermal resveratrol absorption polyvinylpyrrolidone K90 |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1791832 |
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