Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty
Introduction: Significant postoperative bleeding is linked to total knee arthroplasty (TKA), and tranexamic acid (TXA), a strong medication with strong anti-fibrinolytic properties, can lessen surgical bleeding. This study compared the effects of continuous intravenous tranexamic acid infusion with...
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Mashhad University of Medical Sciences
2024-10-01
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| Series: | Patient Safety and Quality Improvement Journal |
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| Online Access: | https://psj.mums.ac.ir/article_25418_018f77a8791c6eb287dd68aa52fd854e.pdf |
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| author | Mohammadali Jafari-zarea Mahzad Yousefian Frouz Amani Hamdollah Panahpour Mahsa Fada |
| author_facet | Mohammadali Jafari-zarea Mahzad Yousefian Frouz Amani Hamdollah Panahpour Mahsa Fada |
| author_sort | Mohammadali Jafari-zarea |
| collection | DOAJ |
| description | Introduction: Significant postoperative bleeding is linked to total knee arthroplasty (TKA), and tranexamic acid (TXA), a strong medication with strong anti-fibrinolytic properties, can lessen surgical bleeding. This study compared the effects of continuous intravenous tranexamic acid infusion with a separate intravenous approach concerning postoperative bleeding in synchronic bilateral knee arthroplasty. Materials and Methods: Hemoglobin changes (24 and 48 hours after surgery), the gases used during the procedure, and the amount of bleeding were assessed in 120 patients who had simultaneous bilateral knee replacement surgery and received intravenous tranexamic acid by continuous infusion (n = 40), single intravenous injection (n = 40), or without injection (n = 40). Results: In 120 patients who underwent simultaneous bilateral knee replacement surgery and received intravenous tranexamic acid by continuous infusion (n = 40), single intravenous injection (n = 40), or no injection (n=40), hemoglobin changes (24, 48 hours postoperatively), the gases used during the procedure, and the extent of bleeding were evaluated. Conclusion: The current study's findings demonstrated that the rate of postoperative hemorrhage and the quantity of gases used in continuous infusion and stat intravenous were reduced compared to the control group. Furthermore, the continuous infusion strategy decreased postoperative hemorrhage and gas consumption compared to the stat intravenous approach. |
| format | Article |
| id | doaj-art-c4136240208d4e24a6145cede35718c0 |
| institution | DOAJ |
| issn | 2345-4482 2345-4490 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Patient Safety and Quality Improvement Journal |
| spelling | doaj-art-c4136240208d4e24a6145cede35718c02025-08-20T02:46:01ZengMashhad University of Medical SciencesPatient Safety and Quality Improvement Journal2345-44822345-44902024-10-0112419720210.22038/psj.2025.83919.144725418Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee ArthroplastyMohammadali Jafari-zarea0Mahzad Yousefian1Frouz Amani2Hamdollah Panahpour3Mahsa Fada4Department of Orthopedic, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.Department of Anethesiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.Department of Community Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.Introduction: Significant postoperative bleeding is linked to total knee arthroplasty (TKA), and tranexamic acid (TXA), a strong medication with strong anti-fibrinolytic properties, can lessen surgical bleeding. This study compared the effects of continuous intravenous tranexamic acid infusion with a separate intravenous approach concerning postoperative bleeding in synchronic bilateral knee arthroplasty. Materials and Methods: Hemoglobin changes (24 and 48 hours after surgery), the gases used during the procedure, and the amount of bleeding were assessed in 120 patients who had simultaneous bilateral knee replacement surgery and received intravenous tranexamic acid by continuous infusion (n = 40), single intravenous injection (n = 40), or without injection (n = 40). Results: In 120 patients who underwent simultaneous bilateral knee replacement surgery and received intravenous tranexamic acid by continuous infusion (n = 40), single intravenous injection (n = 40), or no injection (n=40), hemoglobin changes (24, 48 hours postoperatively), the gases used during the procedure, and the extent of bleeding were evaluated. Conclusion: The current study's findings demonstrated that the rate of postoperative hemorrhage and the quantity of gases used in continuous infusion and stat intravenous were reduced compared to the control group. Furthermore, the continuous infusion strategy decreased postoperative hemorrhage and gas consumption compared to the stat intravenous approach.https://psj.mums.ac.ir/article_25418_018f77a8791c6eb287dd68aa52fd854e.pdftotal knee arthroplastytranexamic acidpostoperative bleeding |
| spellingShingle | Mohammadali Jafari-zarea Mahzad Yousefian Frouz Amani Hamdollah Panahpour Mahsa Fada Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty Patient Safety and Quality Improvement Journal total knee arthroplasty tranexamic acid postoperative bleeding |
| title | Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty |
| title_full | Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty |
| title_fullStr | Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty |
| title_full_unstemmed | Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty |
| title_short | Comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee Arthroplasty |
| title_sort | comparing the effect of intravenous tranexamic acid by continuous infusion method with a separate intravenous method on bleeding after the simultaneous bilateral knee arthroplasty |
| topic | total knee arthroplasty tranexamic acid postoperative bleeding |
| url | https://psj.mums.ac.ir/article_25418_018f77a8791c6eb287dd68aa52fd854e.pdf |
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