Efficacy and safety of enteral supplementation with high-dose vitamin D in critically ill patients with vitamin D deficiency
Background: Vitamin D deficiency is associated with mortality and morbidity in critically ill patients. This study investigated the safety and effectiveness of enteral high-dose vitamin D supplementation in intensive care unit (ICU) patients in Asia. Methods: This was a multicenter, prospective, ran...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-04-01
|
| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664624002419 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850064206886338560 |
|---|---|
| author | An-Yi Wang Yu-Chang Yeh Kuang-Hua Cheng Yin-Yi Han Ching-Tang Chiu Chai-Chi Chang I-Ting Wang Anne Chao |
| author_facet | An-Yi Wang Yu-Chang Yeh Kuang-Hua Cheng Yin-Yi Han Ching-Tang Chiu Chai-Chi Chang I-Ting Wang Anne Chao |
| author_sort | An-Yi Wang |
| collection | DOAJ |
| description | Background: Vitamin D deficiency is associated with mortality and morbidity in critically ill patients. This study investigated the safety and effectiveness of enteral high-dose vitamin D supplementation in intensive care unit (ICU) patients in Asia. Methods: This was a multicenter, prospective, randomized-controlled study. Eligible participants with vitamin D deficiency were randomly assigned to the control or vitamin D supplementation group. In the vitamin D supplementation group, the patients received 569,600 IU vitamin D. The primary outcome was the serum 25(OH)D level on day 7. Results: 41 and 20 patients were included in the vitamin D supplementation and control groups, respectively. On day 7, the serum 25(OH)D level was significantly higher in the vitamin D supplementation group compared to the control group (28.5 [IQR: 20.2–52.6] ng/mL and 13.9 [IQR: 11.6–18.8] ng/mL, p < 0.001). Only 41.5% of the patients achieved serum 25(OH)D levels higher than 30 ng/mL in the supplementation group. This increased level was sustained in the supplementation group on both day 14 and day 28. There were no significant adverse effects noted in the supplementation group. Patients who reached a serum 25(OH)D level of >30 ng/mL on day 7 had a significantly lower 30-day mortality rate than did those who did not (5.9% vs 37.5%, p < 0.05). Conclusions: In our study, less than half of the patients reached adequate vitamin D levels after the enteral administration of high-dose vitamin D. A reduction in 30-day mortality was noted in the patients who achieved adequate vitamin D levels. Trial registration clinicaltrials.gov id: NCT04292873, Registered, March 1, 2020. |
| format | Article |
| id | doaj-art-c40ce5c2e3494b1aa1da60236eaee9ad |
| institution | DOAJ |
| issn | 0929-6646 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj-art-c40ce5c2e3494b1aa1da60236eaee9ad2025-08-20T02:49:22ZengElsevierJournal of the Formosan Medical Association0929-66462025-04-01124435536010.1016/j.jfma.2024.05.005Efficacy and safety of enteral supplementation with high-dose vitamin D in critically ill patients with vitamin D deficiencyAn-Yi Wang0Yu-Chang Yeh1Kuang-Hua Cheng2Yin-Yi Han3Ching-Tang Chiu4Chai-Chi Chang5I-Ting Wang6Anne Chao7Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Emergency Medicine, School of Medicine, College of Medicine, Taipei Medical University, TaiwanDepartment of Anesthesiology, National Taiwan University Hospital, TaiwanDepartment of Critical Care Medicine, Mackay Memorial Hospital, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, TaiwanDepartment of Traumatology, National Taiwan University Hospital, TaiwanDepartment of Anesthesiology, National Taiwan University Hospital, TaiwanDepartment of Anesthesiology, National Taiwan University Hospital, TaiwanDepartment of Critical Care Medicine, Mackay Memorial Hospital, Taiwan; Corresponding author.Department of Anesthesiology, National Taiwan University Hospital, Taiwan; Corresponding authors. Department of Anesthesiology, National Taiwan University Hospital, Taiwan.Background: Vitamin D deficiency is associated with mortality and morbidity in critically ill patients. This study investigated the safety and effectiveness of enteral high-dose vitamin D supplementation in intensive care unit (ICU) patients in Asia. Methods: This was a multicenter, prospective, randomized-controlled study. Eligible participants with vitamin D deficiency were randomly assigned to the control or vitamin D supplementation group. In the vitamin D supplementation group, the patients received 569,600 IU vitamin D. The primary outcome was the serum 25(OH)D level on day 7. Results: 41 and 20 patients were included in the vitamin D supplementation and control groups, respectively. On day 7, the serum 25(OH)D level was significantly higher in the vitamin D supplementation group compared to the control group (28.5 [IQR: 20.2–52.6] ng/mL and 13.9 [IQR: 11.6–18.8] ng/mL, p < 0.001). Only 41.5% of the patients achieved serum 25(OH)D levels higher than 30 ng/mL in the supplementation group. This increased level was sustained in the supplementation group on both day 14 and day 28. There were no significant adverse effects noted in the supplementation group. Patients who reached a serum 25(OH)D level of >30 ng/mL on day 7 had a significantly lower 30-day mortality rate than did those who did not (5.9% vs 37.5%, p < 0.05). Conclusions: In our study, less than half of the patients reached adequate vitamin D levels after the enteral administration of high-dose vitamin D. A reduction in 30-day mortality was noted in the patients who achieved adequate vitamin D levels. Trial registration clinicaltrials.gov id: NCT04292873, Registered, March 1, 2020.http://www.sciencedirect.com/science/article/pii/S0929664624002419Vitamin D deficiencyCritical illnessEfficacySafety |
| spellingShingle | An-Yi Wang Yu-Chang Yeh Kuang-Hua Cheng Yin-Yi Han Ching-Tang Chiu Chai-Chi Chang I-Ting Wang Anne Chao Efficacy and safety of enteral supplementation with high-dose vitamin D in critically ill patients with vitamin D deficiency Journal of the Formosan Medical Association Vitamin D deficiency Critical illness Efficacy Safety |
| title | Efficacy and safety of enteral supplementation with high-dose vitamin D in critically ill patients with vitamin D deficiency |
| title_full | Efficacy and safety of enteral supplementation with high-dose vitamin D in critically ill patients with vitamin D deficiency |
| title_fullStr | Efficacy and safety of enteral supplementation with high-dose vitamin D in critically ill patients with vitamin D deficiency |
| title_full_unstemmed | Efficacy and safety of enteral supplementation with high-dose vitamin D in critically ill patients with vitamin D deficiency |
| title_short | Efficacy and safety of enteral supplementation with high-dose vitamin D in critically ill patients with vitamin D deficiency |
| title_sort | efficacy and safety of enteral supplementation with high dose vitamin d in critically ill patients with vitamin d deficiency |
| topic | Vitamin D deficiency Critical illness Efficacy Safety |
| url | http://www.sciencedirect.com/science/article/pii/S0929664624002419 |
| work_keys_str_mv | AT anyiwang efficacyandsafetyofenteralsupplementationwithhighdosevitamindincriticallyillpatientswithvitaminddeficiency AT yuchangyeh efficacyandsafetyofenteralsupplementationwithhighdosevitamindincriticallyillpatientswithvitaminddeficiency AT kuanghuacheng efficacyandsafetyofenteralsupplementationwithhighdosevitamindincriticallyillpatientswithvitaminddeficiency AT yinyihan efficacyandsafetyofenteralsupplementationwithhighdosevitamindincriticallyillpatientswithvitaminddeficiency AT chingtangchiu efficacyandsafetyofenteralsupplementationwithhighdosevitamindincriticallyillpatientswithvitaminddeficiency AT chaichichang efficacyandsafetyofenteralsupplementationwithhighdosevitamindincriticallyillpatientswithvitaminddeficiency AT itingwang efficacyandsafetyofenteralsupplementationwithhighdosevitamindincriticallyillpatientswithvitaminddeficiency AT annechao efficacyandsafetyofenteralsupplementationwithhighdosevitamindincriticallyillpatientswithvitaminddeficiency |