Bone improvement in osteoporotic rabbits using CoCrMo implants
The management of bone repair in patients with osteoporosis depends on the clinical situation and the extent of the damage. The repair of bone lesions by inducing new bone formation is important for maintaining bone architecture and density. Herein, we reported the use of Cobalt Chromium Molybdenum...
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Engineered Regeneration |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666138124000264 |
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| author | Jésica I. Zuchuat Adriana S. Manzano Valeria Sigot Gastón L. Miño Oscar A. Decco |
| author_facet | Jésica I. Zuchuat Adriana S. Manzano Valeria Sigot Gastón L. Miño Oscar A. Decco |
| author_sort | Jésica I. Zuchuat |
| collection | DOAJ |
| description | The management of bone repair in patients with osteoporosis depends on the clinical situation and the extent of the damage. The repair of bone lesions by inducing new bone formation is important for maintaining bone architecture and density. Herein, we reported the use of Cobalt Chromium Molybdenum (CoCrMo) implants in osteoporotic rabbits and the regenerative outcomes in vivo. The aim was to determine whether the placement of CoCrMo plates would induce qualitative and quantitative differences in the osteoporotic tissue beneath and surrounding the implant. We assessed the effect of the alloy in the bone of animals receiving implants for 4 and 8 weeks and compared the results to those of the osteoporotic non-implanted bone and the healthy controls. After 4 weeks, minimal histological changes were observed, whereas after 8 weeks a marked osteogenesis was evident with both apposition and substitution of new bone. In addition, a greater number of Haversian canals with increased canal area and decreased intracortical pores were observed in the implanted vs non implanted limb for both experimental groups. We show for the first time that the use of CrCoMo plates induces bone formation under osteoporotic conditions. The beneficial effect is localised on the cortical bone in areas in contact with the material. Although this effect may not directly influence the OP disease itself, it has direct implications for new bone formation adjacent to the biomaterial. This potential enhancement could play a crucial role in improving implant fixation in compromised bone, offering increased biocompatibility and stability. |
| format | Article |
| id | doaj-art-c40c7bdff8a640eba4e0fcd90a470409 |
| institution | OA Journals |
| issn | 2666-1381 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Engineered Regeneration |
| spelling | doaj-art-c40c7bdff8a640eba4e0fcd90a4704092025-08-20T02:35:39ZengKeAi Communications Co., Ltd.Engineered Regeneration2666-13812024-12-015449550410.1016/j.engreg.2024.05.002Bone improvement in osteoporotic rabbits using CoCrMo implantsJésica I. Zuchuat0Adriana S. Manzano1Valeria Sigot2Gastón L. Miño3Oscar A. Decco4Laboratorio de Bioimplantes, Facultad de Ingeniería, Universidad Nacional de Entre Rios E3100XAD, Oro Verde, Entre Rios, Argentina; Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática (IBB-CONICET-UNER) E3100XAD, Oro Verde, Entre Rios, Argentina; Correspondence to: Route 11, km 10 E3100XAD, Oro Verde, Entre Ríos, Argentina.CICYTTP: Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción E3105BWA, Diamante, Entre Ríos, ArgentinaInstituto de Investigación y Desarrollo en Bioingeniería y Bioinformática (IBB-CONICET-UNER) E3100XAD, Oro Verde, Entre Rios, Argentina; Laboratorio de Microscopía Aplicada a Estudios Moleculares y Celulares (LAMAE), Facultad de Ingeniería, Universidad Nacional de Entre Ríos E3100XAD, Oro Verde, Entre Ríos, ArgentinaInstituto de Investigación y Desarrollo en Bioingeniería y Bioinformática (IBB-CONICET-UNER) E3100XAD, Oro Verde, Entre Rios, Argentina; Laboratorio de Microscopía Aplicada a Estudios Moleculares y Celulares (LAMAE), Facultad de Ingeniería, Universidad Nacional de Entre Ríos E3100XAD, Oro Verde, Entre Ríos, ArgentinaLaboratorio de Bioimplantes, Facultad de Ingeniería, Universidad Nacional de Entre Rios E3100XAD, Oro Verde, Entre Rios, ArgentinaThe management of bone repair in patients with osteoporosis depends on the clinical situation and the extent of the damage. The repair of bone lesions by inducing new bone formation is important for maintaining bone architecture and density. Herein, we reported the use of Cobalt Chromium Molybdenum (CoCrMo) implants in osteoporotic rabbits and the regenerative outcomes in vivo. The aim was to determine whether the placement of CoCrMo plates would induce qualitative and quantitative differences in the osteoporotic tissue beneath and surrounding the implant. We assessed the effect of the alloy in the bone of animals receiving implants for 4 and 8 weeks and compared the results to those of the osteoporotic non-implanted bone and the healthy controls. After 4 weeks, minimal histological changes were observed, whereas after 8 weeks a marked osteogenesis was evident with both apposition and substitution of new bone. In addition, a greater number of Haversian canals with increased canal area and decreased intracortical pores were observed in the implanted vs non implanted limb for both experimental groups. We show for the first time that the use of CrCoMo plates induces bone formation under osteoporotic conditions. The beneficial effect is localised on the cortical bone in areas in contact with the material. Although this effect may not directly influence the OP disease itself, it has direct implications for new bone formation adjacent to the biomaterial. This potential enhancement could play a crucial role in improving implant fixation in compromised bone, offering increased biocompatibility and stability.http://www.sciencedirect.com/science/article/pii/S2666138124000264OsteoporosisBone formationBone repairTissue engineeringCoCrMo alloy |
| spellingShingle | Jésica I. Zuchuat Adriana S. Manzano Valeria Sigot Gastón L. Miño Oscar A. Decco Bone improvement in osteoporotic rabbits using CoCrMo implants Engineered Regeneration Osteoporosis Bone formation Bone repair Tissue engineering CoCrMo alloy |
| title | Bone improvement in osteoporotic rabbits using CoCrMo implants |
| title_full | Bone improvement in osteoporotic rabbits using CoCrMo implants |
| title_fullStr | Bone improvement in osteoporotic rabbits using CoCrMo implants |
| title_full_unstemmed | Bone improvement in osteoporotic rabbits using CoCrMo implants |
| title_short | Bone improvement in osteoporotic rabbits using CoCrMo implants |
| title_sort | bone improvement in osteoporotic rabbits using cocrmo implants |
| topic | Osteoporosis Bone formation Bone repair Tissue engineering CoCrMo alloy |
| url | http://www.sciencedirect.com/science/article/pii/S2666138124000264 |
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