Limited Joint Mobility Progression in Type 1 Diabetes: A 15-Year Follow-Up Study
Objective. To assess the evolution of joint mobility over a period of 15 years in type 1 diabetic patients and healthy controls and to determine whether microalbuminuria is associated with a different evolution of joint mobility. Methods. Joint mobility of hand and wrist was determined in 63 patient...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/1897058 |
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| author | Javier Labad Antoni Rozadilla Paula Garcia-Sancho Joan M. Nolla Eduard Montanya |
| author_facet | Javier Labad Antoni Rozadilla Paula Garcia-Sancho Joan M. Nolla Eduard Montanya |
| author_sort | Javier Labad |
| collection | DOAJ |
| description | Objective. To assess the evolution of joint mobility over a period of 15 years in type 1 diabetic patients and healthy controls and to determine whether microalbuminuria is associated with a different evolution of joint mobility. Methods. Joint mobility of hand and wrist was determined in 63 patients with type 1 diabetes and 63 healthy subjects. Fifteen years later, 37 (58.7%) diabetic patients and 16 (25.4%) healthy subjects were studied again. Joint mobility was assessed with the Prayer sign and by measuring the angle of maximal flexion of the fifth and third metacarpophalangeal (MCP) joints and wrist. Patients with diabetes were visited 2–4 times every year with regular assessment of glycated hemoglobin (HbA1c), urinary albumin excretion (UAE), and ophthalmoscopy. Results. Fifteen years after the initial exam, diabetic patients showed reduced flexion of the fifth MCP joint (82.6 ± 5.8 versus 76.0 ± 6.4 degrees, p<0.001) and wrist (75.9 ± 8.1 versus 73.2 ± 7.4 degrees, p=0.015) compared to baseline examination. Joint mobility did not change significantly in healthy subjects. Patients with microalbuminuria showed greater reduction in hand joint mobility than diabetic patients with normal UAE or than healthy subjects (p<0.001). Conclusions. In type 1 diabetic patients, the severity of LJM progresses with time, and the progression is enhanced in patients with microalbuminuria. |
| format | Article |
| id | doaj-art-c407bcf6d0ba40358c16ccd4050cfec8 |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c407bcf6d0ba40358c16ccd4050cfec82025-08-20T03:23:11ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/18970581897058Limited Joint Mobility Progression in Type 1 Diabetes: A 15-Year Follow-Up StudyJavier Labad0Antoni Rozadilla1Paula Garcia-Sancho2Joan M. Nolla3Eduard Montanya4Endocrine Unit, Hospital Universitari Bellvitge, L’Hospitalet de Llobregat, Barcelona, SpainRheumatology Section, Hospital Universitari Bellvitge, L’Hospitalet de Llobregat, Barcelona, SpainEndocrine Unit, Hospital Universitari Bellvitge, L’Hospitalet de Llobregat, Barcelona, SpainRheumatology Section, Hospital Universitari Bellvitge, L’Hospitalet de Llobregat, Barcelona, SpainEndocrine Unit, Hospital Universitari Bellvitge, L’Hospitalet de Llobregat, Barcelona, SpainObjective. To assess the evolution of joint mobility over a period of 15 years in type 1 diabetic patients and healthy controls and to determine whether microalbuminuria is associated with a different evolution of joint mobility. Methods. Joint mobility of hand and wrist was determined in 63 patients with type 1 diabetes and 63 healthy subjects. Fifteen years later, 37 (58.7%) diabetic patients and 16 (25.4%) healthy subjects were studied again. Joint mobility was assessed with the Prayer sign and by measuring the angle of maximal flexion of the fifth and third metacarpophalangeal (MCP) joints and wrist. Patients with diabetes were visited 2–4 times every year with regular assessment of glycated hemoglobin (HbA1c), urinary albumin excretion (UAE), and ophthalmoscopy. Results. Fifteen years after the initial exam, diabetic patients showed reduced flexion of the fifth MCP joint (82.6 ± 5.8 versus 76.0 ± 6.4 degrees, p<0.001) and wrist (75.9 ± 8.1 versus 73.2 ± 7.4 degrees, p=0.015) compared to baseline examination. Joint mobility did not change significantly in healthy subjects. Patients with microalbuminuria showed greater reduction in hand joint mobility than diabetic patients with normal UAE or than healthy subjects (p<0.001). Conclusions. In type 1 diabetic patients, the severity of LJM progresses with time, and the progression is enhanced in patients with microalbuminuria.http://dx.doi.org/10.1155/2018/1897058 |
| spellingShingle | Javier Labad Antoni Rozadilla Paula Garcia-Sancho Joan M. Nolla Eduard Montanya Limited Joint Mobility Progression in Type 1 Diabetes: A 15-Year Follow-Up Study International Journal of Endocrinology |
| title | Limited Joint Mobility Progression in Type 1 Diabetes: A 15-Year Follow-Up Study |
| title_full | Limited Joint Mobility Progression in Type 1 Diabetes: A 15-Year Follow-Up Study |
| title_fullStr | Limited Joint Mobility Progression in Type 1 Diabetes: A 15-Year Follow-Up Study |
| title_full_unstemmed | Limited Joint Mobility Progression in Type 1 Diabetes: A 15-Year Follow-Up Study |
| title_short | Limited Joint Mobility Progression in Type 1 Diabetes: A 15-Year Follow-Up Study |
| title_sort | limited joint mobility progression in type 1 diabetes a 15 year follow up study |
| url | http://dx.doi.org/10.1155/2018/1897058 |
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