Seaweed-derived bioactives: Gut microbiota targeted interventions for immune function
Foods resistant to upper gastrointestinal digestion may undergo fermentation by microbial populations within the large intestine, which can induce alterations in the microbial ecology and metabolites, and consequently have implications for host health. Synbiotics are dietary-driven approaches of tar...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000386 |
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| author | Holly Sedgwick Glenn Gibson Jessica Adams Anisha Wijeyesekera |
| author_facet | Holly Sedgwick Glenn Gibson Jessica Adams Anisha Wijeyesekera |
| author_sort | Holly Sedgwick |
| collection | DOAJ |
| description | Foods resistant to upper gastrointestinal digestion may undergo fermentation by microbial populations within the large intestine, which can induce alterations in the microbial ecology and metabolites, and consequently have implications for host health. Synbiotics are dietary-driven approaches of targeting the microbiota to improve immune health. Here, we review the potential of seaweeds, and bacteria able to ferment them, to play a role in the development of next generation synbiotics. Brown seaweed bioactives, particularly polysaccharides, are fermented by the microbiota and may have prebiotic potential, although needs greater confirmation in vivo. Alginate, laminarin, and in some cases fucoidan, have shown to modify the microbiota, its metabolites, and immune system function in in vitro research. Selected species of Bacteroides ferment these polysaccharides and have been shown to exert immunomodulatory effects in animal models. Further research is now required in humans to determine whether combinations of these could offer synergistic benefits for health. |
| format | Article |
| id | doaj-art-c402e67216c24767802f73ea9155babb |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-c402e67216c24767802f73ea9155babb2025-02-09T04:59:59ZengElsevierJournal of Functional Foods1756-46462025-02-01125106696Seaweed-derived bioactives: Gut microbiota targeted interventions for immune functionHolly Sedgwick0Glenn Gibson1Jessica Adams2Anisha Wijeyesekera3Food Microbal Sciences Unit, University of Reading, Whiteknights, Reading, RG6 6AP, UK; Corresponding author.Food Microbal Sciences Unit, University of Reading, Whiteknights, Reading, RG6 6AP, UKInstitutional Affiliation 2 Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, UKFood Microbal Sciences Unit, University of Reading, Whiteknights, Reading, RG6 6AP, UKFoods resistant to upper gastrointestinal digestion may undergo fermentation by microbial populations within the large intestine, which can induce alterations in the microbial ecology and metabolites, and consequently have implications for host health. Synbiotics are dietary-driven approaches of targeting the microbiota to improve immune health. Here, we review the potential of seaweeds, and bacteria able to ferment them, to play a role in the development of next generation synbiotics. Brown seaweed bioactives, particularly polysaccharides, are fermented by the microbiota and may have prebiotic potential, although needs greater confirmation in vivo. Alginate, laminarin, and in some cases fucoidan, have shown to modify the microbiota, its metabolites, and immune system function in in vitro research. Selected species of Bacteroides ferment these polysaccharides and have been shown to exert immunomodulatory effects in animal models. Further research is now required in humans to determine whether combinations of these could offer synergistic benefits for health.http://www.sciencedirect.com/science/article/pii/S1756464625000386SynbioticsPrebioticsSeaweedBioactivesImmune function |
| spellingShingle | Holly Sedgwick Glenn Gibson Jessica Adams Anisha Wijeyesekera Seaweed-derived bioactives: Gut microbiota targeted interventions for immune function Journal of Functional Foods Synbiotics Prebiotics Seaweed Bioactives Immune function |
| title | Seaweed-derived bioactives: Gut microbiota targeted interventions for immune function |
| title_full | Seaweed-derived bioactives: Gut microbiota targeted interventions for immune function |
| title_fullStr | Seaweed-derived bioactives: Gut microbiota targeted interventions for immune function |
| title_full_unstemmed | Seaweed-derived bioactives: Gut microbiota targeted interventions for immune function |
| title_short | Seaweed-derived bioactives: Gut microbiota targeted interventions for immune function |
| title_sort | seaweed derived bioactives gut microbiota targeted interventions for immune function |
| topic | Synbiotics Prebiotics Seaweed Bioactives Immune function |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000386 |
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