Small cell osteosarcoma in gnathic bones in the maxilla: case report in a pediatric patient
Abstract Small cell osteosarcoma (SCOS) is a rare variant of conventional osteosarcoma, characterized by tumor cells of small size and uniform morphology, which can lead to diagnostic confusion with other small cell tumors, requiring a detailed diagnostic approach. The manifestation in a child adds...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
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| Online Access: | https://doi.org/10.1007/s00432-024-06079-5 |
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| author | Tayná Souza Gomes da Silva Ilan Hudson Gomes de Santana Helder Domiciano Dantas Martins Raabe Carine Ferreira de Melo Paulo Rogério Ferreti Bonan |
| author_facet | Tayná Souza Gomes da Silva Ilan Hudson Gomes de Santana Helder Domiciano Dantas Martins Raabe Carine Ferreira de Melo Paulo Rogério Ferreti Bonan |
| author_sort | Tayná Souza Gomes da Silva |
| collection | DOAJ |
| description | Abstract Small cell osteosarcoma (SCOS) is a rare variant of conventional osteosarcoma, characterized by tumor cells of small size and uniform morphology, which can lead to diagnostic confusion with other small cell tumors, requiring a detailed diagnostic approach. The manifestation in a child adds a degree of complexity, as the management of malignant tumours in paediatric patients requires specific considerations to minimize the long-term side effects of oncological treatment and preserve the structural and functional development of the orofacial region. This report concerns an 8-year-old female patient referred to the Oral and Maxillofacial Surgery outpatient clinic with progressive swelling in the right maxillofacial region, initially asymptomatic, but progressing to pain and difficulty chewing. A cone beam computed tomography scan was requested and an incisional biopsy was carried out for histopathological and immunohistochemical analysis, which confirmed the pathological entity. The lesion was then completely resected with a safety margin and the affected area removed to restore functionality and aesthetics. The surgical specimen was sent for further histopathological analysis, which confirmed the diagnosis of SCOS. Detailed immunohistochemical analysis was crucial to the diagnosis, and a comprehensive surgical approach was indicated given the aggressive behavior of the lesion. This report emphasizes the importance of an integrated multidisciplinary approach, combining oncology, pathology and oral and maxillofacial surgery. |
| format | Article |
| id | doaj-art-c400c8a8d1104c4596e1570d344476f8 |
| institution | Kabale University |
| issn | 1432-1335 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-c400c8a8d1104c4596e1570d344476f82025-02-09T12:10:07ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352025-01-0115111910.1007/s00432-024-06079-5Small cell osteosarcoma in gnathic bones in the maxilla: case report in a pediatric patientTayná Souza Gomes da Silva0Ilan Hudson Gomes de Santana1Helder Domiciano Dantas Martins2Raabe Carine Ferreira de Melo3Paulo Rogério Ferreti Bonan4Health Sciences Center, Federal University of Paraíba (CCS/UFPB)Health Sciences Center, Federal University of Paraíba (CCS/UFPB)Health Sciences Center, Federal University of Paraíba (CCS/UFPB)Health Sciences Center, Federal University of Paraíba (CCS/UFPB)Health Sciences Center, Federal University of Paraíba (CCS/UFPB)Abstract Small cell osteosarcoma (SCOS) is a rare variant of conventional osteosarcoma, characterized by tumor cells of small size and uniform morphology, which can lead to diagnostic confusion with other small cell tumors, requiring a detailed diagnostic approach. The manifestation in a child adds a degree of complexity, as the management of malignant tumours in paediatric patients requires specific considerations to minimize the long-term side effects of oncological treatment and preserve the structural and functional development of the orofacial region. This report concerns an 8-year-old female patient referred to the Oral and Maxillofacial Surgery outpatient clinic with progressive swelling in the right maxillofacial region, initially asymptomatic, but progressing to pain and difficulty chewing. A cone beam computed tomography scan was requested and an incisional biopsy was carried out for histopathological and immunohistochemical analysis, which confirmed the pathological entity. The lesion was then completely resected with a safety margin and the affected area removed to restore functionality and aesthetics. The surgical specimen was sent for further histopathological analysis, which confirmed the diagnosis of SCOS. Detailed immunohistochemical analysis was crucial to the diagnosis, and a comprehensive surgical approach was indicated given the aggressive behavior of the lesion. This report emphasizes the importance of an integrated multidisciplinary approach, combining oncology, pathology and oral and maxillofacial surgery.https://doi.org/10.1007/s00432-024-06079-5OsteosarcomaSarcomaSmall CellCase ReportsPathologyOral |
| spellingShingle | Tayná Souza Gomes da Silva Ilan Hudson Gomes de Santana Helder Domiciano Dantas Martins Raabe Carine Ferreira de Melo Paulo Rogério Ferreti Bonan Small cell osteosarcoma in gnathic bones in the maxilla: case report in a pediatric patient Journal of Cancer Research and Clinical Oncology Osteosarcoma Sarcoma Small Cell Case Reports Pathology Oral |
| title | Small cell osteosarcoma in gnathic bones in the maxilla: case report in a pediatric patient |
| title_full | Small cell osteosarcoma in gnathic bones in the maxilla: case report in a pediatric patient |
| title_fullStr | Small cell osteosarcoma in gnathic bones in the maxilla: case report in a pediatric patient |
| title_full_unstemmed | Small cell osteosarcoma in gnathic bones in the maxilla: case report in a pediatric patient |
| title_short | Small cell osteosarcoma in gnathic bones in the maxilla: case report in a pediatric patient |
| title_sort | small cell osteosarcoma in gnathic bones in the maxilla case report in a pediatric patient |
| topic | Osteosarcoma Sarcoma Small Cell Case Reports Pathology Oral |
| url | https://doi.org/10.1007/s00432-024-06079-5 |
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