Ginkgolide B attenuates hyperlipidemia by restoring sphingolipid homeostasis and activating PPARα and Nrf2 pathways

Ginkgolide B attenuates hyperlipidemia by restoring sphingolipid homeostasis and activating PPARα and Nrf2 pathways

Abstract Although hyperlipidemia is a key factor in cardiovascular disease, there are limited safe and effective therapies for disorders of lipid metabolism. This study investigated the therapeutic potential of Ginkgolide B (GB), a bioactive component of Ginkgo biloba leaves, in ameliorating hyperli...

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Bibliographic Details
Main Authors: Yun Liu, Feng Wang, Hengyu Xu, Hongxin Wang, Meili Lu, Lan Cheng
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Ginkgolide B
Hyperlipidemia
Lipid metabolism
Ceramide
Sphingomyelin
Online Access:https://doi.org/10.1038/s41598-025-14626-4
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