Long-term epilepsy associated-tumors (LEATs): what is new?
Long-term epilepsy-associated tumors (LEATs) include a series of neoplasms that commonly occur in children, adolescents, or young adults, have an astrocytic or glioneuronal lineage, are histologically benign (WHO grade1) with a neocortical localization predominantly situated in the temporal lobes. C...
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Thieme Revinter Publicações
2023-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777730 |
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| author | Sergio Rosemberg |
| author_facet | Sergio Rosemberg |
| author_sort | Sergio Rosemberg |
| collection | DOAJ |
| description | Long-term epilepsy-associated tumors (LEATs) include a series of neoplasms that commonly occur in children, adolescents, or young adults, have an astrocytic or glioneuronal lineage, are histologically benign (WHO grade1) with a neocortical localization predominantly situated in the temporal lobes. Clinically, chronic refractory epilepsy is usually the unique symptom. Gangliogliomas (GG) and dysembryoplastic neuroepithelial tumors (DNT) are the most common representative entities besides pilocytic astrocytomas (PA) and angiocentric gliomas (AG). Recent molecular studies have defined new clinicopathological entities, which are recognized by the WHO 2021 classification of brain tumors. Some of them such as diffuse astrocytoma MIB or MYBL1 altered, polymorphous low-grade neuroepithelial tumor of the young (PLNTY), and multilocular and vacuolating neuronal tumor (MVNT) are currently considered LEATs. The relationship between LEATs and epilepsy is still a matter of debate, and there is a general agreement about the beneficial effects of an early neurosurgical intervention on the clinical outcome. |
| format | Article |
| id | doaj-art-c3f910baa3f64520ad6a0c36d10e694f |
| institution | OA Journals |
| issn | 0004-282X 1678-4227 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-c3f910baa3f64520ad6a0c36d10e694f2025-08-20T02:18:56ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42272023-12-0181121146115110.1055/s-0043-1777730Long-term epilepsy associated-tumors (LEATs): what is new?Sergio Rosemberg0https://orcid.org/0000-0001-8843-8557Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo SP, Brazil.Long-term epilepsy-associated tumors (LEATs) include a series of neoplasms that commonly occur in children, adolescents, or young adults, have an astrocytic or glioneuronal lineage, are histologically benign (WHO grade1) with a neocortical localization predominantly situated in the temporal lobes. Clinically, chronic refractory epilepsy is usually the unique symptom. Gangliogliomas (GG) and dysembryoplastic neuroepithelial tumors (DNT) are the most common representative entities besides pilocytic astrocytomas (PA) and angiocentric gliomas (AG). Recent molecular studies have defined new clinicopathological entities, which are recognized by the WHO 2021 classification of brain tumors. Some of them such as diffuse astrocytoma MIB or MYBL1 altered, polymorphous low-grade neuroepithelial tumor of the young (PLNTY), and multilocular and vacuolating neuronal tumor (MVNT) are currently considered LEATs. The relationship between LEATs and epilepsy is still a matter of debate, and there is a general agreement about the beneficial effects of an early neurosurgical intervention on the clinical outcome.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777730EpilepsyBrain NeoplasmsAstrocytomaNeoplasms, NeuroepithelialEpilepsiaNeoplasias EncefálicasAstrocitomaNeoplasias Neuroepiteliomatosas |
| spellingShingle | Sergio Rosemberg Long-term epilepsy associated-tumors (LEATs): what is new? Arquivos de Neuro-Psiquiatria Epilepsy Brain Neoplasms Astrocytoma Neoplasms, Neuroepithelial Epilepsia Neoplasias Encefálicas Astrocitoma Neoplasias Neuroepiteliomatosas |
| title | Long-term epilepsy associated-tumors (LEATs): what is new? |
| title_full | Long-term epilepsy associated-tumors (LEATs): what is new? |
| title_fullStr | Long-term epilepsy associated-tumors (LEATs): what is new? |
| title_full_unstemmed | Long-term epilepsy associated-tumors (LEATs): what is new? |
| title_short | Long-term epilepsy associated-tumors (LEATs): what is new? |
| title_sort | long term epilepsy associated tumors leats what is new |
| topic | Epilepsy Brain Neoplasms Astrocytoma Neoplasms, Neuroepithelial Epilepsia Neoplasias Encefálicas Astrocitoma Neoplasias Neuroepiteliomatosas |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777730 |
| work_keys_str_mv | AT sergiorosemberg longtermepilepsyassociatedtumorsleatswhatisnew |