Association of miR-203 Expression with Prognostic Value in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis
Objective This study aims to investigate the association between miR-203 expression and the prognostic value in patients with esophageal cancer by the method of systematic review and meta-analysis.Methods We searched PubMed, Web of Science, Embase, and Cochrane Library to collect studies on the rela...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Journal of Investigative Surgery |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/08941939.2023.2285780 |
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| _version_ | 1850185111975231488 |
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| author | Qirun Cheng Lipeng Chen Liping Ni |
| author_facet | Qirun Cheng Lipeng Chen Liping Ni |
| author_sort | Qirun Cheng |
| collection | DOAJ |
| description | Objective This study aims to investigate the association between miR-203 expression and the prognostic value in patients with esophageal cancer by the method of systematic review and meta-analysis.Methods We searched PubMed, Web of Science, Embase, and Cochrane Library to collect studies on the relationship between miR-203 expression and the prognostic value of esophageal cancer up to July 2023. Stata 15.0 statistical software was used for data analysis. Hazard ratio (HR) and 95% confidence interval (CI) were used as effect sizes.Results A total of 6 studies were included in this review, including 476 patients with esophageal cancer. The results showed that miR-203 low expression was associated with worse overall survival (OS) in patients with esophageal cancer compared with miR-203 high expression (HR = 2.80, 95%CI: 1.99 ∼ 3.93, p < 0.001). The results of Egger’s (p = 0.154) and Begg’s Tests (p = 0.221) indicated no obvious publication bias. Sensitivity analysis verified the robustness of the results obtained in this study.Conclusion The expression of miR-203 is significantly correlated with the prognostic value in patients with esophageal cancer. Esophageal cancer patients with high expression of miR-203 had better prognosis than those with low expression of miR-203. Due to the limited studies included in this meta-analysis, more trials are needed to confirm the conclusions of this study in the future. |
| format | Article |
| id | doaj-art-c3f0240c70464ce2ad5cbc23b26cb40c |
| institution | OA Journals |
| issn | 0894-1939 1521-0553 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj-art-c3f0240c70464ce2ad5cbc23b26cb40c2025-08-20T02:16:49ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532023-12-0136110.1080/08941939.2023.2285780Association of miR-203 Expression with Prognostic Value in Patients with Esophageal Cancer: A Systematic Review and Meta-AnalysisQirun Cheng0Lipeng Chen1Liping Ni2Department of Gastroenterology, Zhejiang Hospital, Hangzhou, Zhejiang, ChinaDepartment of Gastroenterology, Zhejiang Hospital, Hangzhou, Zhejiang, ChinaDepartment of Gastroenterology, Zhejiang Hospital, Hangzhou, Zhejiang, ChinaObjective This study aims to investigate the association between miR-203 expression and the prognostic value in patients with esophageal cancer by the method of systematic review and meta-analysis.Methods We searched PubMed, Web of Science, Embase, and Cochrane Library to collect studies on the relationship between miR-203 expression and the prognostic value of esophageal cancer up to July 2023. Stata 15.0 statistical software was used for data analysis. Hazard ratio (HR) and 95% confidence interval (CI) were used as effect sizes.Results A total of 6 studies were included in this review, including 476 patients with esophageal cancer. The results showed that miR-203 low expression was associated with worse overall survival (OS) in patients with esophageal cancer compared with miR-203 high expression (HR = 2.80, 95%CI: 1.99 ∼ 3.93, p < 0.001). The results of Egger’s (p = 0.154) and Begg’s Tests (p = 0.221) indicated no obvious publication bias. Sensitivity analysis verified the robustness of the results obtained in this study.Conclusion The expression of miR-203 is significantly correlated with the prognostic value in patients with esophageal cancer. Esophageal cancer patients with high expression of miR-203 had better prognosis than those with low expression of miR-203. Due to the limited studies included in this meta-analysis, more trials are needed to confirm the conclusions of this study in the future.https://www.tandfonline.com/doi/10.1080/08941939.2023.2285780miR-203esophageal cancermeta-analysis |
| spellingShingle | Qirun Cheng Lipeng Chen Liping Ni Association of miR-203 Expression with Prognostic Value in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis Journal of Investigative Surgery miR-203 esophageal cancer meta-analysis |
| title | Association of miR-203 Expression with Prognostic Value in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis |
| title_full | Association of miR-203 Expression with Prognostic Value in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis |
| title_fullStr | Association of miR-203 Expression with Prognostic Value in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association of miR-203 Expression with Prognostic Value in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis |
| title_short | Association of miR-203 Expression with Prognostic Value in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis |
| title_sort | association of mir 203 expression with prognostic value in patients with esophageal cancer a systematic review and meta analysis |
| topic | miR-203 esophageal cancer meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/08941939.2023.2285780 |
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